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H5N2 is a subtype of the species Influenzavirus A (avian influenza virus or bird flu virus). The subtype infects a wide variety of birds, including chickens, ducks, turkeys, falcons, and ostriches. Affected birds usually do not appear ill, and the disease is often mild as avian influenza viral subtypes go. Some variants of the subtype are much more pathogenic than others, and outbreaks of "high-path" H5N2 result in the culling of thousands of birds in poultry farms from time to time. It appears that people who work with birds can be infected by the virus, but suffer hardly any noticeable health effects. Even people exposed to the highly pathogenic H5N2 variety that killed ostrich chicks in South Africa only seem to have developed conjunctivitis, or a perhaps a mild respiratory illness. There is no evidence of human-to-human spread of H5N2.
Low pathogenic avian influenza H5N2 virus in poultry later gained accentuated virulence in the United States  and Mexico. A highly pathogenic strain of H5N2 caused flu outbreaks with significant spread to numerous farms, resulting in great economic losses in 1983 in Pennsylvania, USA in chickens and turkeys, in 1994 in Mexico in chickens and a minor outbreak in 1997 in Italy in chickens.
In Korea, ducks have been destroyed at the farm since quarantine officials detected the suspected low pathogenic H5N2 strain of avian influenza on December 1, 2004.
In Japan, H5N2 virus was isolated or an anti-H5 antibody was identified from chickens in 40 chicken farms in Ibaraki Prefecture and in one chicken farm in Saitama Prefecture from June through December 2005. The strain was named as A/ chicken /Ibaraki/1/2005(H5N2). About 5.7 million birds were destroyed in Ibaraki following the H5N2 outbreaks.
In 2006, an H5N2 outbreak on a single farm in South Africa resulted in the destruction of all its sixty ostriches. The strain was similar to the one that caused outbreaks in South Africa 2004/2005.
In 2007, a low-pathogenic strain of H5N2 was found in samples collected from 25,000 turkeys in West Virginia in a routine testing prior to their slaughter. The birds showed no sign of illness or mortality. Measures were taken to prevent the virus from mutating and spreading.
In late 2007 (December 21), an H5N2 outbreak was found in the Dominican Republic. 15 roosters and 2 hens where eliminated even though they had no visible sign of infection.
In May and June 2008, there were three outbreaks of low-pathogenic H5N2 avian flu in birds at three locations in the central, northern, and southern parts of Haiti.
In Taiwan, outbreaks of H5N2 have been confirmed in December 2008.
In Sri Lanka outbreak of H5N2 in Bingiriya have been confirmed by the Health Ministry in January 2012. Around 5000-6000 chicken were destroyed, after some of them were confirmed having infected with H5N2. 
In 2012 a strain of highly pathogenic avian influenza is devastating the South African commercial ostrich industry with 41,000 birds already been reported culled. 
In March of 2012, the first documented occurrence in Taiwan of highly pathogenic avian influenza H5N2 in was reported to the World Organization for Animal Health (OIE). The outbreak began in February 2012. 
Japan's Health Ministry said in January, 2006 that poultry farm workers in Ibaraki prefecture may have been exposed to H5N2 (which was not previously known to infect humans) in 2005. Data were collected from 257 workers at 35 chicken farms by Ibaraki prefectural government. It was determined that their H5N2 antibody titers after the outbreak were significantly higher than those collected prior to the outbreak.