Immunoglobulin heavy chain

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Schematic diagram of a typical antibody showing two Ig heavy chains (blue) linked by disulfide bonds to two Ig light chains (green). The constant (C) and variable (V) domains are shown.
An antibody molecule. The two heavy chains are colored red and blue and the two light chains green and yellow. See also:[1]

The immunoglobulin heavy chain (IgH) is the large polypeptide subunit of an antibody (immunoglobulin).

A typical antibody is composed of two immunoglobulin (Ig) heavy chains and two Ig light chains. Several different types of heavy chain exist that define the class or isotype of an antibody. These heavy chain types vary between different animals. All heavy chains contain a series of immunoglobulin domains, usually with one variable domain (VH) that is important for binding antigen and several constant domains (CH1, CH2, etc.).


In mammals


There are five types of mammalian immunoglobulin heavy chain: γ, δ, α, μ and ε.[1] They define classes of immunoglobulins: IgG, IgD, IgA, IgM and IgE, respectively.


Each heavy chain has two regions:

In fish

Jawed fish appear to be the most primitive animals that are able to make antibodies like those described for mammals.[3] However, fish do not have the same repertoire of antibodies that mammals possess.[4] Three distinct Ig heavy chains have so far been identified in bony fish.

Similar to the situation observed for bony fish, three distinct Ig heavy chain isotypes have been identified in cartilaginous fish. With the exception of μ, these Ig heavy chain isotypes appear to be unique to cartilaginous fish. The resulting antibodies are designated IgW (also called IgX or IgNARC) and IgNAR ('immunoglobulin new antigen receptor').[8][9] The latter type is a heavy-chain antibody, an antibody lacking light chains, and can be used to produce single-domain antibodies, which are essentially the variable domain of an IgNAR.[10]

See also


  1. ^ a b c Janeway CA, Jr. et al. (2001). Immunobiology. (5th ed. ed.). Garland Publishing. (electronic full text via NCBI Bookshelf) ISBN 0-8153-3642-X. 
  2. ^ Woof J, Burton D (2004). "Human antibody-Fc receptor interactions illuminated by crystal structures". Nat Rev Immunol 4 (2): 89–99. doi:10.1038/nri1266. PMID 15040582. 
  3. ^ Fish heavy chain and light chain genes
  4. ^ Eva Bengtén, L. William Clem, Norman W. Miller, Gregory W. Warr and Melanie Wilson. Channel catfish immunoglobulins: Repertoire and expression. Developmental & Comparative Immunology, Volume 30, Issues 1-2, Antibody repertoire development, 2006, Pages 77-92.
  5. ^ Stein Tore Solem and Jørgen Stenvik. Antibody repertoire development in teleosts--a review with emphasis on salmonids and Gadus morhua L. Developmental & Comparative Immunology, Volume 30, Issues 1-2, Antibody repertoire development, 2006, Pages 57-76.
  6. ^ J.D. Hansen, E.D. Landis and R.B. Phillips. Discovery of a unique Ig heavy-chain isotype (IgT) in rainbow trout: Implications for a distinctive B cell developmental pathway in teleost fish. Proceedings of the National Academy of Sciences U S A. Volume 102, Issue 19, 2005, pages 6919-24.
  7. ^ N. Danilova, J. Bussmann, K. Jekosch, L.A Steiner. The immunoglobulin heavy-chain locus in zebrafish: identification and expression of a previously unknown isotype, immunoglobulin Z. Nature Immunology, Volume 6, Issue 3, 2005, pages 295-302.
  8. ^ H. Dooley and M.F. Flajnik. Antibody repertoire development in cartilaginous fish. Developmental & Comparative Immunology, Volume 30, Issues 1-2, Antibody repertoire development, 2006, Pages 43-56.
  9. ^ Simmons, D.; Abregu, F.; Krishnan, U.; Proll, D.; Streltsov, V.; Doughty, L.; Hattarki, M.; Nuttall, S. (2006). "Dimerisation strategies for shark IgNAR single domain antibody fragments". Journal of immunological methods 315 (1–2): 171–184. doi:10.1016/j.jim.2006.07.019. PMID 16962608.  edit
  10. ^ Wesolowski, J.; Alzogaray, V.; Reyelt, J.; Unger, M.; Juarez, K.; Urrutia, M.; Cauerhff, A.; Danquah, W. et al. (2009). "Single domain antibodies: promising experimental and therapeutic tools in infection and immunity". Medical Microbiology and Immunology 198 (3): 157–174. doi:10.1007/s00430-009-0116-7. PMC 2714450. PMID 19529959. //  edit

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