Hypertensive nephropathy

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Hypertensive nephropathy
Classification and external resources
Renal arterial hyalinosis - pas - very high mag.jpg
Micrograph showing renal arterial hyalinosis - pink ring right-of-centre. PAS stain.
ICD-10I12
ICD-9403
 
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Hypertensive nephropathy
Classification and external resources
Renal arterial hyalinosis - pas - very high mag.jpg
Micrograph showing renal arterial hyalinosis - pink ring right-of-centre. PAS stain.
ICD-10I12
ICD-9403

Hypertensive nephropathy (or "hypertensive nephrosclerosis", or "Hypertensive renal disease") is a medical condition referring to damage to the kidney due to chronic high blood pressure.

It should be distinguished from "renovascular hypertension" (I15.0), which is a form of secondary hypertension.

In the kidneys, as a result of benign arterial hypertension, hyaline (pink, amorphous, homogeneous material) accumulates in the wall of small arteries and arterioles, producing the thickening of their walls and the narrowing of the lumina — hyaline arteriolosclerosis. Consequent ischemia will produce tubular atrophy, interstitial fibrosis, glomerular alterations (smaller glomeruli with different degrees of hyalinization - from mild to sclerosis of glomeruli) and periglomerular fibrosis. In advanced stages, renal failure will occur. Functional nephrons have dilated tubules, often with hyaline casts in the lumens. Additional complications often associated with hypertensive nephropathy include glomerular damage resulting in proteinuria and hematuria.

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