From Wikipedia, the free encyclopedia - View original article

Jump to: navigation, search
Weeds killed with herbicide

Herbicides, also commonly known as weedkillers, are pesticides used to kill unwanted plants.[1] Selective herbicides kill specific targets, while leaving the desired crop relatively unharmed. Some of these act by interfering with the growth of the weed and are often synthetic mimics of natural plant hormones. Herbicides used to clear waste ground, industrial sites, railways and railway embankments are not selective and kill all plant material with which they come into contact. Smaller quantities are used in forestry, pasture systems, and management of areas set aside as wildlife habitat.

Some plants produce natural herbicides, such as the genus Juglans (walnuts), or the tree of heaven; such action of natural herbicides, and other related chemical interactions, is called allelopathy.

Herbicides are widely used in agriculture and landscape turf management. In the US, they account for about 70% of all agricultural pesticide use.[1]


Prior to the widespread use of chemical herbicides, cultural controls, such as altering soil pH, salinity, or fertility levels, were used to control weeds. Mechanical control (including tillage) was also (and still is) used to control weeds.

First herbicides[edit]

2,4-D, the first chemical herbicide, was discovered during the Second World War.

Although research into chemical herbicides began in the early 20th century, the first major breakthrough was the result of research conducted in both the UK and the US during the Second World War into the potential use of agents as biological weapons.[2] The first modern herbicide, 2,4-D, was first discovered and synthesized by W. G. Templeman at Imperial Chemical Industries. In 1940, he showed that "Growth substances applied appropriately would kill certain broad-leaved weeds in cereals without harming the crops." By 1941, his team succeeded in synthesizing the chemical. In the same year, Pokorny in the US achieved this as well.[3]

Independently, a team under Juda Hirsch Quastel, working at the Rothamsted Experimental Station made the same discovery. Quastel was tasked by the Agricultural Research Council (ARC) to discover methods for improving crop yield. By analyzing soil as a dynamic system, rather than an inert substance, he was able to apply techniques such as perfusion. Quastel was able to quantify the influence of various plant hormones, inhibitors and other chemicals on the activity of microorganisms in the soil and assess their direct impact on plant growth. While the full work of the unit remained secret, certain discoveries were developed for commercial use after the war, including the 2,4-D compound.[4]

When it was commercially released in 1946, it triggered a worldwide revolution in agricultural output and became the first successful selective herbicide. It allowed for greatly enhanced weed control in wheat, maize (corn), rice, and similar cereal grass crops, because it kills dicots (broadleaf plants), but not most monocots (grasses). The low cost of 2,4-D has led to continued usage today, and it remains one of the most commonly used herbicides in the world. Like other acid herbicides, current formulations use either an amine salt (often trimethylamine) or one of many esters of the parent compound. These are easier to handle than the acid.

Further discoveries[edit]

The triazine family of herbicides, which includes atrazine, were introduced in the 1950s; they have the current distinction of being the herbicide family of greatest concern regarding groundwater contamination. Atrazine does not break down readily (within a few weeks) after being applied to soils of above neutral pH. Under alkaline soil conditions, atrazine may be carried into the soil profile as far as the water table by soil water following rainfall causing the aforementioned contamination. Atrazine is thus said to have "carryover", a generally undesirable property for herbicides.

Glyphosate (Roundup) was introduced in 1974 for nonselective weed control. Following the development of glyphosate-resistant crop plants, it is now used very extensively for selective weed control in growing crops. The pairing of the herbicide with the resistant seed contributed to the consolidation of the seed and chemistry industry in the late 1990s.

Many modern chemical herbicides for agriculture are specifically formulated to decompose within a short period after application. This is desirable, as it allows crops which may be affected by the herbicide to be grown on the land in future seasons. However, herbicides with low residual activity (i.e., that decompose quickly) often do not provide season-long weed control.

Health and environmental effects[edit]

Herbicides have widely variable toxicity. In addition to acute toxicity from occupational exposure levels.

Some herbicides cause a range of health effects ranging from skin rashes to death. The pathway of attack can arise from intentional or unintentional direct consumption, improper application resulting in the herbicide coming into direct contact with people or wildlife, inhalation of aerial sprays, or food consumption prior to the labeled preharvest interval. Under some conditions, certain herbicides can be transported via leaching or surface runoff to contaminate groundwater or distant surface water sources. Generally, the conditions that promote herbicide transport include intense storm events (particularly shortly after application) and soils with limited capacity to adsorb or retain the herbicides. Herbicide properties that increase likelihood of transport include persistence (resistance to degradation) and high water solubility.[5]

Phenoxy herbicides are often contaminated with dioxins such as TCDD; research has suggested such contamination results in a small rise in cancer risk after occupational exposure to these herbicides.[6] Triazine exposure has been implicated in a likely relationship to increased risk of breast cancer, although a causal relationship remains unclear.[7]

Herbicide manufacturers have at times made false or misleading claims about the safety of their products. Chemical manufacturer Monsanto Company agreed to change its advertising after pressure from New York attorney general Dennis Vacco; Vacco complained about misleading claims that its spray-on glyphosate-based herbicides, including Roundup, were safer than table salt and "practically non-toxic" to mammals, birds, and fish (though proof that this was ever said is hard to find).[8] Roundup is toxic and has resulted in death after being ingested in quantities ranging from 85 to 200 ml, although it has also been ingested in quantities as large as 500 ml with only mild or moderate symptoms.[9] The manufacturer of Tordon 101 (Dow AgroSciences, owned by the Dow Chemical Company) has claimed Tordon 101 has no effects on animals and insects,[10] in spite of evidence of strong carcinogenic activity of the active ingredient[11] Picloram in studies on rats.[12]

The risk of Parkinson's disease has been shown to increase with occupational exposure to herbicides and pesticides.[13] The herbicide paraquat is suspected to be one such factor.[14]

All commercially sold, organic and nonorganic herbicides must be extensively tested prior to approval for sale and labeling by the Environmental Protection Agency. However, because of the large number of herbicides in use, concern regarding health effects is significant. In addition to health effects caused by herbicides themselves, commercial herbicide mixtures often contain other chemicals, including inactive ingredients, which have negative impacts on human health.[citation needed]

Ecological effects[edit]

Commercial herbicide use generally has negative impacts on bird populations, although the impacts are highly variable and often require field studies to predict accurately. Laboratory studies have at times overestimated negative impacts on birds due to toxicity, predicting serious problems that were not observed in the field.[15] Most observed effects are due not to toxicity, but to habitat changes and the decreases in abundance of species on which birds rely for food or shelter. Herbicide use in silviculture, used to favor certain types of growth following clearcutting, can cause significant drops in bird populations. Even when herbicides which have low toxicity to birds are used, they decrease the abundance of many types of vegetation on which the birds rely.[16] Herbicide use in agriculture in Britain has been linked to a decline in seed-eating bird species which rely on the weeds killed by the herbicides.[17] Heavy use of herbicides in neotropical agricultural areas has been one of many factors implicated in limiting the usefulness of such agricultural land for wintering migratory birds.[18]

Frog populations may be affected negatively by the use of herbicides as well. While some studies have shown that atrazine may be a teratogen, causing demasculinization in male frogs,[19] the U.S. Environmental Protection Agency (EPA) and its independent Scientific Advisory Panel (SAP) examined all available studies on this topic and concluded that "atrazine does not adversely affect amphibian gonadal development based on a review of laboratory and field studies."[20]

Scientific uncertainty[edit]

The health and environmental effects of many herbicides is unknown, and even the scientific community often disagrees on the risk. For example, a 1995 panel of 13 scientists reviewing studies on the carcinogenicity of 2,4-D had divided opinions on the likelihood 2,4-D causes cancer in humans.[21] As of 1992, studies on phenoxy herbicides were too few to accurately assess the risk of many types of cancer from these herbicides, even though evidence was stronger that exposure to these herbicides is associated with increased risk of soft tissue sarcoma and non-Hodgkin lymphoma.[22] Furthermore, there is some suggestion that herbicides[which?] can play a role in sex reversal of certain organisms that experience temperature-dependent sex determination, which could theoretically alter sex ratios.[23]


Scientists generally agree selection pressure applied to weed populations for a long enough period of time eventually leads to resistance. Plants have developed resistance to atrazine and to ALS-inhibitors, and more recently, to glyphosate herbicides. Marestail is one weed that has developed glyphosate resistance.[24]

Glyphophate-resistant weeds are present in the vast majority of soybean, cotton and corn farms in some U.S. states. Weeds that can resist multiple other herbicides are spreading. Few new herbicides are near commercialization, and none with a molecular mode of action for which there is no resistance. Because most herbicides could not kill all weeds, farmers rotated crops and herbicides to stop resistant weeds. During its initial years, glyphosphate was not subject to resistance and allowed farmers to reduce the use of rotation.[25]

A family of weeds that includes waterhemp (Amaranthus rudis) is the largest concern. A 2008-9 survey of 144 populations of waterhemp in 41 Missouri counties revealed glyphosate resistance in 69%. Weeds from some 500 sites throughout Iowa in 2011 and 2012 revealed glyphosate resistance in approximately 64% of waterhemp samples. The use of other killers to target "residual" weeds has become common, and may be sufficient to have stopped the spread of resistance From 2005 through 2010 researchers discovered 13 different weed species that had developed resistance to glyphosate. But since then only two more have been discovered. Weeds resistant to multiple herbicides with completely different biological action modes are on the rise. In Missouri, 43% of samples were resistant to two different herbicides; 6% resisted three; and 0.5% resisted four. In Iowa 89% of waterhemp samples resist two or more herbicides, 25% resist three, and 10% resist five.[25]

For southern cotton, herbicide costs has climbed from between $50 and $75 per hectare a few years ago to about $370 per hectare in 2013. Resistance is contributing to a massive shift away from growing cotton; over the past few years, the area planted with cotton has declined by 70% in Arkansas and by 60% in Tennessee. For soybeans in Illinois, costs have risen from about $25 to $160 per hectare.[25]

Dow, Bayer CropScience, Syngenta and Monsanto are all developing seed varieties resistant to herbicides other than glyphosate, which will make it easier for farmers to use alternative weed killers. Even though weeds have already evolved some resistance to those herbicides, Powles says the new seed-and-herbicide combos should work well if used with proper rotation.[25]

Farming practices[edit]

Herbicide resistance became a critical problem after many Australian sheep farmers began to exclusively grow wheat in their pastures in the 1970s. Introduced varieties of ryegrass, while good for grazing sheep, compete intensely with wheat. Ryegrasses produce so many seeds that, if left unchecked, they can completely choke a field. Herbicides provided excellent control, while reducing soil disrupting because of less need to plough. Within little more than a decade, ryegrass and other weeds began to develop resistance. In response Australian farmers changed methods.[26]

In 1983, patches of ryegrass had become immune to Hoegrass, a family of herbicides that inhibit an enzyme called acetyl coenzyme A carboxylase.[26]

Ryegrass populations were large, and had substantial genetic diversity, because farmers had planted many varieties. Ryegrass is cross-pollinated by wind, so genes shuffle frequently. To control its distribution farmers sprayed inexpensive Hoegrass, creating selection pressure. In addition, farmers sometimes diluted the herbicide in order to save money, which allowed some plants to survive application. When resistance appeared farmers turned to a group of herbicides that block acetolactate synthase. Once again, ryegrass in Australia evolved a kind of "cross-resistance" that allowed it to rapidly break down a variety of herbicides. Four classes of herbicides become ineffective within a few years. In 2013 only two herbicide classes, called Photosystem II and long-chain fatty acid inhibitors, were effective against ryegrass.[26]


Herbicides can be grouped by activity, use, chemical family, mode of action, or type of vegetation controlled.

By activity:

By use:

  1. Preplant incorporated herbicides are soil applied prior to planting and mechanically incorporated into the soil. The objective for incorporation is to prevent dissipation through photodecomposition and/or volatility.
  2. Pre-emergent herbicides are applied to the soil before the crop emerges and prevent germination or early growth of weed seeds.
  3. Postemergent herbicides are applied after the crop has emerged.

Their classification by mechanism of action (MOA) indicates the first enzyme, protein, or biochemical step affected in the plant following application. The main mechanisms of action are:

Organic herbicides[edit]

Recently, the term "organic" has come to imply products used in organic farming. Under this definition, an organic herbicide is one that can be used in a farming enterprise that has been classified as organic. Commercially sold organic herbicides are expensive and may not be affordable for commercial farming.[citation needed] Depending on the application, they may be less effective than synthetic herbicides and are generally used along with cultural and mechanical weed control practices.

Homemade organic herbicides include:


Most herbicides are applied as water-based sprays using ground equipment. Ground equipment varies in design, but large areas can be sprayed using self-propelled sprayers equipped with long booms, of 60 to 80 feet (18 to 24 m) with flat-fan nozzles spaced about every 20 inches (510 mm). Towed, handheld, and even horse-drawn sprayers are also used.

Synthetic organic herbicides can generally be applied aerially using helicopters or airplanes, and can be applied through irrigation systems (chemigation).

A new method of herbicide application involves ridding the soil of its active weed seed bank rather than just killing the weed. Researchers at the Agricultural Research Service have found the application of herbicides to fields late in the weeds' growing season greatly reduces their seed production, and therefore fewer weeds will return the following season. Because most weeds are annual grasses, their seeds will only survive in soil for a year or two, so this method will be able to “weed out” the weed with only a few years of herbicide application.[38]

Weed-wiping may also be used, where a wick wetted with herbicide is suspended from a boom and dragged or rolled across the tops of the taller weed plants. This allows treatment of taller grassland weeds by direct contact without affecting related but desirable plants in the grassland sward beneath.


Herbicide volatilisation or drift may result in herbicide affecting neighboring fields or plants, particularly in windy conditions. Sometimes, the wrong field or plants may be sprayed due to error.


In current use[edit]

Historical interest: 2,4,5-T[edit]

See also[edit]


  1. ^ a b Kellogg RL, Nehring R, Grube A, Goss DW, and Plotkin S (February 2000). "Environmental indicators of pesticide leaching and runoff from farm fields". United States Department of Agriculture Natural Resources Conservation Service. Retrieved 2010-08-26. 
  2. ^ Andrew H. Cobb, John P. H. Reade (2011). "7.1". Herbicides and Plant Physiology. John Wiley & Sons. 
  3. ^ Robert L Zimdahl (2007). A History of Weed Science in the United States. Elsevier. 
  4. ^ Quastel, J. H. (1950). "2,4-Dichlorophenoxyacetic Acid (2,4-D) as a Selective Herbicide". "Agricultural Control Chemicals". Advances in Chemistry 1. p. 244. doi:10.1021/ba-1950-0001.ch045. ISBN 0-8412-2442-0. 
  5. ^ PL Havens, GK Sims, S Erhardt-Zabik. 1995. Fate of herbicides in the environment. Handbook of weed management systems. M. Dekker, 245-278
  6. ^ Kogevinas, M; Becher, H; Benn, T et al. (1997). "Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins. An expanded and updated international cohort study". American Journal of Epidemiology 145 (12): 1061–75. doi:10.1093/oxfordjournals.aje.a009069. PMID 9199536. 
  7. ^ Kettles, MK; Browning, SR; Prince, TS; Horstman, SW (1997). "Triazine herbicide exposure and breast cancer incidence: An ecologic study of Kentucky counties". Environmental health perspectives 105 (11): 1222–7. doi:10.1289/ehp.971051222. PMC 1470339. PMID 9370519. 
  8. ^ "Monsanto Pulls Roundup Advertising in New York". Wichita Eagle. Nov 27, 1996. 
  9. ^ Talbot, AR; Shiaw, MH; Huang, JS; Yang, SF; Goo, TS; Wang, SH; Chen, CL; Sanford, TR (1991). "Acute poisoning with a glyphosate-surfactant herbicide ('Roundup'): A review of 93 cases". Human & Experimental Toxicology 10 (1): 1–8. doi:10.1177/096032719101000101. PMID 1673618. 
  10. ^ "Complaints halt herbicide spraying in Eastern Shore". CBC News. June 16, 2009. 
  11. ^ "Tordon 101: picloram/2,4-D", Ontario Ministry of Agriculture Food & Rural Affairs
  12. ^ Reuber, MD (1981). "Carcinogenicity of Picloram". Journal of Toxicology and Environmental Health 7 (2): 207–222. doi:10.1080/15287398109529973. PMID 7014921. 
  13. ^ Gorell, JM; Johnson, CC; Rybicki, BA; Peterson, EL; Richardson, RJ (1998). "The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living". Neurology 50 (5): 1346–50. doi:10.1212/WNL.50.5.1346. PMID 9595985. 
  14. ^ Dinis-Oliveira, R.J.; Remião, F.; Carmo, H.; Duarte, J.A.; Navarro, A. Sánchez; Bastos, M.L.; Carvalho, F. (2006). "Paraquat exposure as an etiological factor of Parkinson's disease". NeuroToxicology 27 (6): 1110–22. doi:10.1016/j.neuro.2006.05.012. PMID 16815551. 
  15. ^ Blus, Lawrence J.; Henny, Charles J. (1997). "Field Studies on Pesticides and Birds: Unexpected and Unique Relations". Ecological Applications 7 (4): 1125. doi:10.1890/1051-0761(1997)007[1125:FSOPAB]2.0.CO;2. 
  16. ^ MacKinnon, D. S. and Freedman, B. (1993). "Effects of Silvicultural Use of the Herbicide Glyphosate on Breeding Birds of Regenerating Clearcuts in Nova Scotia, Canada". Journal of Applied Ecology 30 (3): 395–406. doi:10.2307/2404181. JSTOR 2404181. 
  17. ^ Newton, Ian (2004). "The recent declines of farmland bird populations in Britain: An appraisal of causal factors and conservation actions". Ibis 146 (4): 579. doi:10.1111/j.1474-919X.2004.00375.x. 
  18. ^ Robbins, C.S.; Dowell, B.A.; Dawson, D.K.; Colon, J.A.; Estrada, R.; Sutton, A.; Sutton, R.; Weyer, D. (1992). "Comparison of neotropical migrant landbird populations wintering in tropical forest, isolated forest fragments, and agricultural habitats". In Hagan, John M. and Johnston, David W. Ecology and Conservation of Neotropical Migrant Landbirds. Smithsonian Institution Press, Washington and London. pp. 207–220. ISBN 156098113X. 
  19. ^ Hayes, Tyrone B., et al. "Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses." Proceedings of the National Academy of Sciences 99.8 (2002): 5476-5480.
  20. ^ Environmental Protection Agency: Atrazine Updates. Current as of January 2013, URL accessed August 24, 2013.
  21. ^ Ibrahim MA, Bond GG, Burke TA, Cole P, Dost FN, Enterline PE, Gough M, Greenberg RS, Halperin WE, McConnell E, et al. (1991). "Weight of the evidence on the human carcinogenicity of 2,4-D". Environ Health Perspect 96: 213–222. doi:10.1289/ehp.9196213. PMC 1568222. PMID 1820267. 
  22. ^ Howard I. Morrison, Kathryn Wilkins, Robert Semenciw, Yang Mao, Don Wigle (1992). "Herbicides and Cancer". Journal of the National Cancer Institute 84 (24): 1866–1874. doi:10.1093/jnci/84.24.1866. PMID 1460670. 
  23. ^ Gilbert, Scott F (2010). Developmental Biology (9th ed.). Sinauer Associates. p. [page needed]. ISBN 978-0-87893-384-6. 
  24. ^ Marking, Syl (January 1, 2002) "Marestail Jumps Glyphosate Fence", Corn and Soybean Digest.
  25. ^ a b c d Service, R. F. (2013). "What Happens when Weed Killers Stop Killing?". Science 341 (6152): 1329. doi:10.1126/science.341.6152.1329.  edit
  26. ^ a b c Stokstad, E. (2013). "The War Against Weeds Down Under". Science 341 (6147): 734. doi:10.1126/science.341.6147.734.  edit
  27. ^ a b Stryer, Lubert (1995). Biochemistry, 4th Edition. W.H. Freeman and Company. p. 670. ISBN 0-7167-2009-4. 
  28. ^ Moran GR. 4-Hydroxyphenylpyruvate dioxygenase Arch Biochem Biophys. 2005 Jan 1;433(1):117-28.doi:10.1023/A:1005458703363 PMID 15581571
  29. ^ Wolfgang Kramer and Ulrich Schirmer, Modern Crop Protection Compounds (1)197-276(2012)
  30. ^ Andreas van Almsick, New HPPD-Inhibitors - A Proven Mode of Action as a New Hope to Solve Current Weed Problems, Outlooks on Pest Management, 20(1) 27-30(2009
  31. ^ Lock EA et al. From toxicological problem to therapeutic use: the discovery of the mode of action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), its toxicology and development as a drug. J Inherit Metab Dis. 1998 Aug;21(5):498-506. PMID 9728330
  32. ^ McDade, Melissa C.; Christians, Nick E. (2009). "Corn gluten meal—a natural preemergence herbicide: Effect on vegetable seedling survival and weed cover". American Journal of Alternative Agriculture 15 (4): 189. doi:10.1017/S0889189300008778. 
  33. ^ Spray Weeds With Vinegar?. Ars.usda.gov. Retrieved on 2013-03-05.
  34. ^ Weed Management in Landscapes. Ipm.ucdavis.edu. Retrieved on 2013-03-05.
  35. ^ Lanini, W. Thomas Organic Weed Management in Vineyards. University of California, Davis
  36. ^ Kolberg, Robert L., and Lori J. Wiles (2002). "Effect of Steam Application on Cropland Weeds1". Weed Technology 16: 43. doi:10.1614/0890-037X(2002)016[0043:EOSAOC]2.0.CO;2. 
  37. ^ Flame weeding for vegetable crops. Attra.ncat.org (2011-10-12). Retrieved on 2013-03-05.
  38. ^ "A New Way to Use Herbicides: To Sterilize, Not Kill Weeds". USDA Agricultural Research Service. May 5, 2010. 
  39. ^ Fluazifop. Herbiguide.com.au. Retrieved on 2013-03-05.
  40. ^ IMAZAMOX | Pacific Northwest Weed Management Handbook. Pnwhandbooks.org. Retrieved on 2013-03-05.

Further reading[edit]

External links[edit]

General Information
Regulatory policy