The series chronicles the lives of three sisters, Mary Bartnicki (age 83), Josie Cavaluzzi (age 73) & Teresa Dahlquist (age 73). The trio became an overnight sensation after their video of them watching and commenting on the Kim Kardashian sex tape went viral. The managing of Josie's salon, giving advice to their fan base and giving their opinions on pop culture are also shown.
Mary discovers that one of her admired singers, Engelbert Humperdinck, is performing at a nearby casino. Mary and her sisters prepare for a night out on the town to see him perform. Prior to the outing, the trio choose to receive makeovers. While at the concert, Mary jumps on stage due to her overwhelming excitement.
The sisters head out to Las Vegas. Mary is set to compete in a poker tournament at the Palazzo Hotel while her sisters go out for a day of food, fun and tons of gambling. Teresa tries the Master Cleanse diet prior to the trip but the diet doesn't turn out the way she plans. No trip to Las Vegas is complete without some rule breaking.
Teresa is asked "What is the biggest risk you've ever taken?". Her answer is was when she purchased a talent agency, which she had no background in and its pilot season, that means it is time to discover new talent. Teresa's assistant has called in sick and she asks her sisters for help in the office.