GlaxoSmithKline

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GlaxoSmithKline plc
TypePublic limited company
Traded asLSEGSK
NYSEGSK
IndustryPharmaceutical
Biotechnology
Predecessor(s)Glaxo Wellcome plc
SmithKline Beecham plc
Founded2000 (London)
HeadquartersLondon, United Kingdom
Key peopleChris Gent (Chairman)
Andrew Witty (Chief Executive)
ProductsPharmaceuticals, vaccines, oral healthcare products, nutritional products, over-the-counter medicines
Revenue£27.387 billion (2011)[1]
Operating income£10.397 billion (2011)[1]
Net income£5.458 billion (2011)[1]
Total assets£41.080 billion (2011)[1]
Total equity£8.032 billion (2011)[1]
Employees97,389 (2011)[2]
SubsidiariesStiefel Laboratories
Websitewww.gsk.com
 
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GlaxoSmithKline plc
TypePublic limited company
Traded asLSEGSK
NYSEGSK
IndustryPharmaceutical
Biotechnology
Predecessor(s)Glaxo Wellcome plc
SmithKline Beecham plc
Founded2000 (London)
HeadquartersLondon, United Kingdom
Key peopleChris Gent (Chairman)
Andrew Witty (Chief Executive)
ProductsPharmaceuticals, vaccines, oral healthcare products, nutritional products, over-the-counter medicines
Revenue£27.387 billion (2011)[1]
Operating income£10.397 billion (2011)[1]
Net income£5.458 billion (2011)[1]
Total assets£41.080 billion (2011)[1]
Total equity£8.032 billion (2011)[1]
Employees97,389 (2011)[2]
SubsidiariesStiefel Laboratories
Websitewww.gsk.com

GlaxoSmithKline plc (GSK) (LSEGSK, NYSEGSK) is a British multinational pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom. It is the world's fourth-largest pharmaceutical company measured by 2009 prescription drug sales (after Pfizer, Novartis, and Sanofi).[3] It was established in 2000 by the merger of Glaxo Wellcome plc (formed from the acquisition of Wellcome plc by Glaxo plc) and SmithKline Beecham plc (formed from the merger of Beecham plc and SmithKline Beckman Corporation, which was formed by combining the Smith Kline French and Beckman companies).

GSK has a portfolio of products for major disease areas including asthma, cancer, virus control, infections, mental health, diabetes, and digestive conditions.[4] It also has a large consumer healthcare division which produces and markets oral healthcare and nutritional products and over-the-counter medicines including Sensodyne, Boost, Horlicks, and Gaviscon.[4][5] In July 2012, GSK pleaded guilty to criminal charges and agreed to a $3 billion settlement of the largest health-care fraud case in the U.S. and the largest payment by a drug company in the US.[6][7] The settlement is related to the company's illegal promotion of best-selling anti-depressants and its failure to report safety data about a top diabetes drug.[8]

GSK has a primary listing on the London Stock Exchange and is a constituent of the FTSE 100 Index. As of 6 July 2012, it had a market capitalisation of £74.8 billion, the fifth-largest of any company listed on the London Stock Exchange.[9] It has a secondary listing on the New York Stock Exchange.

Contents

History

GSK was formed in 2000 by the merger of GlaxoWellcome plc (formed from the acquisition of Wellcome plc by Glaxo plc), and SmithKline Beecham plc (formed from the merger of Beecham plc and SmithKline Beckman Corporation).

GlaxoWellcome

The historic Glaxo factory in Bunnythorpe, New Zealand

In 1880, Burroughs Wellcome & Company was founded in London by the American pharmacists Henry Wellcome and Silas Burroughs.[10] The Wellcome Tropical Research Laboratories opened in 1902.[10] In 1959, the Wellcome Company bought Cooper, McDougall & Robertson Inc. to become more active in animal health.[10] The Wellcome Company production centre was moved from New York to North Carolina in 1970, and the following year another research centre was built. Glaxo was founded in Bunnythorpe, New Zealand, in 1904.[10] Originally Glaxo was a baby food manufacturer processing milk into a baby food of the same name: the product was sold under the slogan "Glaxo builds bonny babies" from 1908. Still visible on the main street of Bunnythorpe is a dairy factory (factory for drying and processing cows' milk into powder) with the original Glaxo logo clearly visible, it is now a car repair shop.

Glaxo became Glaxo Laboratories, and opened new units in London in 1935.[10] Glaxo Laboratories bought two companies, Joseph Nathan and Allen & Hanburys, in 1947 and 1958 respectively.[10] After the company bought Meyer Laboratories in 1978,[10] it started to play an important role in the US market. In 1983 the American arm Glaxo Inc. moved to Research Triangle Park (US headquarters/research) and Zebulon (US manufacturing) in North Carolina. Burroughs Wellcome and Glaxo merged in 1995 to form GlaxoWellcome.[10] In the same year, GlaxoWellcome opened its Medicine Research Centre in Stevenage.[10] Three years later GlaxoWellcome bought Polfa Poznan Company in Poland.[10]

SmithKline Beecham

Beecham's Clock Tower, constructed in 1877 as part of the Beecham factory in St Helens

In 1843, Thomas Beecham launched his Beecham's Pills laxative in England giving birth to the Beecham Group.[10] Beecham opened its first factory in St Helens, Lancashire, England for rapid production of medicines in 1859. The original factory was closed in 1994 and passed to the local college for re-development. By the 1960s, Beecham was extensively involved in pharmaceuticals.

In 1830, John K. Smith opened its first pharmacy in Philadelphia.[10] In 1865, Mahlon Kline joined the business which 10 years later became Smith, Kline & Co.[10] Subsequently, in 1891, it merged with French, Richard and Company.[10] It changed its name to Smith Kline & French Laboratories as it focused more on research in 1929. Years later, Smith Kline & French Laboratories opened a new laboratory in Philadelphia; it then bought Norden Laboratories, a business doing research into animal health.

Smith Kline & French Laboratories bought Recherche et Industrie Thérapeutiques (Belgium) in 1963 in order to focus on vaccines.[10] The company started to expand globally, buying seven laboratories in Canada and the US in 1969. In 1982, it bought Allergan, a manufacturer of eye and skincare products.[10] The company merged with Beckman Inc. later that year and changed its name to SmithKline Beckman.[10]

In 1988, SmithKline Beckman bought its biggest competitor, International Clinical Laboratories,[10] and in 1989 merged with Beecham to form SmithKline Beecham plc.[10] The headquarters of the company was moved to England. To expand research & development in the US, SmithKline Beecham bought a new research center in 1995. Another new research centre at New Frontiers Science Park in Harlow was opened in 1997.[10]

2000 to 2011

GSK House, the current world headquarters of GlaxoSmithKline in Brentford, London

Glaxo Wellcome and SmithKline Beecham announced their intention to merge on 17 January 2000.[11][12] Following receipt of necessary regulatory approvals, the merger was completed in December 2000, forming GlaxoSmithKline.[13]

In 2001, GSK completed the acquisition of New Jersey-based Block Drug for US$1.24 billion.[14] In July 2002 GSK House, located in Brentford, London, was officially opened as GSK's new world headquarters by then-Prime Minister Tony Blair.[15] The building was built at a cost of £300 million and is home to around 3,000 staff.[15] In October 2006 GSK acquired the US-based consumer healthcare company CNS Inc., whose products included Breathe Right nasal strips and FiberChoice dietary fibre supplements, for US$566 million in cash.[16] GSK opened its first R&D centre in China in May 2007, located in Shanghai and initially focused on neurodegenerative diseases.[17][18]

Since 2008, GSK has been running clinical trials of a new malaria vaccine. The vaccine, which is known as RTS,S, has been in development for more than 25 years, at first for the American military and then with major support from the Bill and Melinda Gates Foundation. The clinical trial is scheduled to continue through 2014 and will include tests on more than 15,000 children, starting at infancy.[19]

In February 2009, GSK head Andrew Witty announced that the company would cut drug prices by 25% in 50 of the poorest nations, release intellectual property rights for substances and processes relevant to neglected disease into a patent pool to encourage new drug development, and invest 20% of profits from the least developed countries in medical infrastructure for those countries.[20] The decision has received mixed reactions from medical charities.[21][22] Médecins Sans Frontières welcomed the decision, encouraging other companies to follow suit, but criticised GSK for failing to include HIV patents in their patent pool, and for not including middle-income countries in the initiative.[23]

In April 2009 GSK agreed to acquire the US-based dermatological pharmaceuticals company Stiefel Laboratories for US$3.6 billion (£2.5 billion).[24][25]

On 16 November 2009, the US Food and Drug Administration (FDA) announced that a vaccine for 2009 H1N1 influenza protection (manufactured by GSK's ID Biomedical Corp. subsidiary) would join the four vaccines approved on 15 September.[26] In June 2010, the company acquired Laboratorios Phoenix, an Argentine pharmaceutical company focused on the development, marketing and sale of branded generic products, for a cash consideration of approximately $253m.[27]

In November 2009, GlaxoSmithKline formed a joint venture with Pfizer to create ViiV Healthcare. Viiv Healthcare received all of Pfizer and GlaxoSmithKline's HIV assets.[28] ViiV Healthcare is 85% owned by GlaxoSmithKline and 15% owned by Pfizer. In December 2010, GSK announced its acquisition of the UK-based sports nutrition company Maxinutrition for £162 million (US$256 million).[29]

2011 to present

In February 2011, GSK announced plans to sell some "non-core" brands. In December 2011, the company agreed to a $660 million deal with Prestige Brands Holdings, which will take over 17 brands with sales of $210 million, including BC Powder, Beano, Ecotrin, Fiber Choice, Goody's Powder, Sominex, and Tagamet.[30] In March 2012 GSK announced plans to invest around £500 million in manufacturing facilities in Ulverston, northern England, designating it as the site for a previously announced biotech plant.[31]

GSK made a US$2.6 billion (£1.6 billion) offer for the United States-based biopharmaceutical company Human Genome Sciences in April 2012.[32][33]

Operations

The GlaxoSmithKline Biologicals facility in Dresden, Germany

GSK employs 97,000 people worldwide[34] of whom about 12,500 work in research and development. Its global headquarters are GSK House in Brentford, United Kingdom, with its United States headquarters based in Research Triangle Park in North Carolina[35] and its consumer products division based in the Pittsburgh suburb of Moon Township, Pennsylvania. The research and development division has major facilities in South East England, Philadelphia and Research Triangle Park in North Carolina. GSK has a presence in 99 cities across 39 countries.

GSK's single largest market is in the United States, which generates approximately 45% of its revenues, although the company sells its products in around 70 countries.

Major facilities

The headquarters of GlaxoSmithKline Japan in Tokyo

Major GSK facilities include:

Products

GSK's current products include:

Personal care

Oral healthcare products include the Aquafresh, Macleans, Biotene and Sensodyne toothpaste and related product ranges.

Corporate affairs

Stockmarket listings

GSK's stock is listed on the London stock exchange and ADRs are listed on the NYSE.

Senior management

Andrew Witty, who has been the chief executive officer of GlaxoSmithKline since May 2008.

As of December 2012, the current members of GSK's board of directors are:[36]

Corporate social responsibility

Disease eradication

GSK has been active in a global alliance[clarification needed] to eliminate lymphatic filariasis.[37] Jean-Pierre (JP) Garnier, former CEO of GlaxoSmithKline has said, “The Egyptian data shows that we can now eliminate a disease that has plagued the world for centuries. We remain committed to donating as much albendazole as required to eliminate this disabling disease, but ultimate success will depend on continued long-term commitments by all partners across the globe.”

In addition GlaxoSmithKline has been short-listed for awards such as the Worldaware Business Award for its work to eliminate malaria in Kenya.[38]

GlaxoSmithKline recently[when?] donated money to the British flood appeal, and was ranked first on the 2006 UK Corporate Citizenship Index for donations.[39]

Diversity

GSK was named one of the 100 Best Companies for Working Mothers in 2007 by Working Mother magazine[40] and was recognised by the International Charter for its efforts. GSK also received a perfect score of 100 percent from the Human Rights Campaign Foundation's 2008 Corporate Equality Index, an annual report card of corporate America's treatment of gay, lesbian, bisexual, and transgender (GLBT) employees, customers and investors. GSK also supports employee diversity networks for groups such as ECN, PTPN, GLBT, AAA, etc.

Controversies

Avandia

On 14 June 2007, an article was published by Steve Nissen, Chair of the Division of Cardiovascular Medicine at the Cleveland Clinic in the New England Journal of Medicine. This meta-analysis showed an increased odds ratio of myocardial infarction in patients taking rosiglitazone marketed as Avandia. More recently, the New York Times published an article detailing Nissen's conversation with pharmaceutical executives. These conversations were recorded unbeknownst to the GSK executives but are legal in the State of Ohio as long as one participating party is aware. Currently, a Congressional investigation has been initiated to determine what information was known at the time of the approval of rosiglitazone as well as post approval and whether or not GSK wilfully suppressed such information. In February 2010, GlaxoSmithKline tried to suppress publishing of a critical article[41] concerning rosiglitazone.[42] In July, a US Finance Committee Letter asserted GSK had "to publish studies in a timely manner that found problems with Avandia".[43]

In November 2007, a United States congressional committee released a report[44] describing intimidation of Dr John Buse (University of North Carolina at Chapel Hill)[45][46] by GlaxoSmithKline over his concerns about the cardiovascular risks associated with the company's anti-diabetes drug rosiglitazone (Avandia).[47]

Paroxetine

Paroxetine (Seroxat, Paxil) is an SSRI anti-depressant released in 1992 by GlaxoSmithKline. For 10 years, GlaxoSmithKline (GSK) marketing of the drug stated that it was "not habit forming," which numerous experts and at least one court found to be incorrect.[48][49][50] Since the FDA approved paroxetine in 1992, approximately 5,000 U.S. citizens have sued GSK. Most of these people feel they were not sufficiently warned in advance of the drug's side effects—particularly the withdrawal syndrome, after GSK had specifically advertised the drug as non-habit forming. Since 2001 in the UK, lawsuits have been filed representing people who have been prescribed Seroxat. They allege that the drug has serious side effects, which GlaxoSmithKline downplayed in patient information.[51][52] In 2001, the BBC reported the World Health Organization had ranked paroxetine as the most difficult antidepressant to withdraw from. In 2002, the U.S. FDA published a new product warning about the drug, and the International Federation of Pharmaceutical Manufacturers Associations said GSK had misled the public about paroxetine and breached two of the Federation's codes of practice.[53]

In early 2004, GSK agreed to settle charges of consumer fraud for $2.5 million (a tiny fraction of the over $2.7 billion in yearly Paxil sales at that time).[54] The legal discovery process also uncovered evidence of deliberate, systematic suppression of unfavorable Paxil research results. One of GSK's internal documents had said, "It would be commercially unacceptable to include a statement that efficacy [in children] had not been demonstrated, as this would undermine the profile of paroxetine".[55]

In June 2004, FDA published a violation letter to GSK in response to a "false or misleading" TV ad for Paxil CR; FDA stated, "This ad is concerning from a public health perspective because it broadens the use of Paxil CR [beyond the conditions it was approved for] while also minimizing the serious risks associated with the drug."[56] GSK claimed the ad had been previously reviewed by FDA, but said the ad would not run again.[57]

In March 2008 the Medicines and Healthcare Products Regulatory Agency concluded that GSK should have warned of the possible ill effects of taking Seroxat a lot sooner.[58] GSK could not be prosecuted under the old legislation. As of 2008, GlaxoSmithKline's prescribing information acknowledges that "serious discontinuation symptoms" may occur.[59] The court documents released as a result of one of the lawsuits in October 2008 indicated that GSK "and/or researchers may have suppressed or obscured suicide risk data during clinical trials" of paroxetine.[60] The suppression of unfavorable research findings on Paxil by GSK – and the legal discovery process that uncovered it – is the subject of Alison Bass's 2008 book Side Effects: A Prosecutor, a Whistleblower, and a Bestselling Antidepressant on Trial.[61]

In 2012 the U.S. Justice Department announced that GSK had agreed to plead guilty and pay a $3 billion fine, in part for promoting the use of Paxil for children.[62]

Ribena

On 27 March 2007, GSK pleaded guilty in an Auckland District Court to 15 charges relating to misleading conduct brought under the Fair Trading Act by New Zealand's Commerce Commission. The charges related to the popular blackcurrant fruit drink Ribena, which the company had led consumers to believe contained high levels of vitamin C. As part of a school science project, Anna Devathasan and Jenny Suo, 14-year-old schoolgirls from Pakuranga College in Auckland, discovered that ready-to-drink juice sold in 100ml containers contained very little vitamin C. Approaches by the two teens to the company did not resolve the issue, and after the matter was publicised on national consumer affairs television show Fair Go it came to the attention of the Commerce Commission. The commission's testing found that ready-to-drink Ribena contained no detectable vitamin C.

The company was fined $217,000 for the 15 charges. The number of charges was reduced from 88 and covered the period from March 2002 to March 2006. GSK maintains that it did not intend to mislead consumers and that the advertising claims were based on testing procedures that have since been changed. It was ordered to run an advertising campaign to provide the facts after it admitted misleading the public about the vitamin C component in its Ribena drink. Through its lawyer, Adam Ross, the company accepted Commerce Commission allegations that claims that ready-to-drink Ribena contained 7 mg of vitamin C per 100ml, or 44% of the recommended daily intake, were incorrect. The company also agreed television advertising claiming the blackcurrants in Ribena had four times the vitamin C of oranges, while literally true, were likely to mislead consumers about the relative levels of vitamin C in Ribena.[63]

Health-care fraud settlement

On 2 July 2012, GSK pleaded guilty to criminal charges and agreed to a $3 billion settlement of the largest health-care fraud case in the U.S. and the largest payment by a drug company.[7] The settlement is related to the company's illegal promotion of prescription drugs, its failure to report safety data,[64] bribing doctors, and promoting medicines for uses for which they were not licensed. The drugs involved were Paxil, Wellbutrin, Advair, Lamictal, and Zofran for off-label, non-covered uses. Those and the drugs Imitrex, Lotronex, Flovent, and Valtrex were involved in the kickback scheme.[65][66][67][further explanation needed] The government investigation of GSK was launched largely on the basis of information provided by four whistleblowers who filed two qui tam (whistleblower) lawsuits against the company under the False Claims Act. GSK settled the whistleblowers’ lawsuits for a total of $1.017 billion out of the $3 billion settlement, the largest civil False Claims Act settlement to date.[68]

Other

See also

References

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