Tim Dog, frustrated at being overlooked because of the popularity of the West Coast at the time and at the apparent lack of interest in East Coast artists from record companies, released the song on his debut album Penicillin on Wax. "Fuck Compton" attacked the city's style of dress and musical output and made threatening gestures to several Compton rappers including Eazy-E, MC Ren, Dr. Dre and singer Michel'le. Tim Dog made clear that he was not including West Coast rapper Ice-T in the diss with the line "I crush Ice Cube, I'm cool with Ice-T/But N.W.A ain't shit to me." The song could also be looked at as the origin of the East Coast-West Coast hip hop rivalry that escalated during the 1990s.
Tweedy Bird Loc and Dangerous Records responded on "Fucc The South Bronx" and "What's Really Goin' On" on his debut album 187 Ride By.
E.L. Me & The Street Products responded on the tracks "E.L. Me & The Street Products" and "Outshout" from their debut album "16 Lessons From The Streets".
Wu-Tang Clan affiliate Shabazz the Disciple referenced "Fuck Compton" in a more positive light in his 2003 song "Red Hook Day" - "And fuck a fair one, you got your head snuffed and stomped in/back when that nigga Tim Dog made 'Fuck Compton'"