Forskolin

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Forskolin
Forskolin.svg
Identifiers
CAS number66428-89-5 YesY
PubChem47936
ChemSpider43607 YesY
UNII1F7A44V6OU YesY
DrugBankDB02587
ChEBICHEBI:42471 YesY
ChEMBLCHEMBL52606 YesY
Jmol-3D imagesImage 1
Properties
Molecular formulaC22H34O7
Molar mass410.50 g mol−1
Solubilitysoluble in organic solvents such as ethanol, chloroform and DMSO[1]
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references
 
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Forskolin
Forskolin.svg
Identifiers
CAS number66428-89-5 YesY
PubChem47936
ChemSpider43607 YesY
UNII1F7A44V6OU YesY
DrugBankDB02587
ChEBICHEBI:42471 YesY
ChEMBLCHEMBL52606 YesY
Jmol-3D imagesImage 1
Properties
Molecular formulaC22H34O7
Molar mass410.50 g mol−1
Solubilitysoluble in organic solvents such as ethanol, chloroform and DMSO[1]
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

Forskolin (also called Coleonol) is a labdane diterpene that is produced by the Indian Coleus plant (Coleus forskohlii). Forskolin is commonly used to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology. Forskolin activates the enzyme adenylyl cyclase and increases intracellular levels of cAMP. cAMP is an important second messenger necessary for the proper biological response of cells to hormones and other extracellular signals. It is required for cell communication in the hypothalamus/pituitary gland axis and for the feedback control of hormones. Cyclic AMP acts by activating cAMP-sensitive pathways such as protein kinase A and Epac. Further reading: function of protein kinase A

Biosynthesis[edit]

Chemical, Biological and Medical Potential[edit]

In: "Innovative approaches in drug Research", A.F. Harms (Editor), Elsevier Science Publishers B.V., Amsterdam. 1986. p. 191-207; Forskolin - The Chemical Entity and Structure Activity Relationships of Forskolin and its Derivatives. de Souza N.J. In: Rupp, RH; de Souza, NJ; Dohadwalla, AN.(Eds). Proceedings of an international symposium on "Forskolin: Its Chemical, Biological and Medical Potential", Hoechst India Limited, Bombay. 1985. 5-12, 39-50;Structures and Sterochemistry of new Labdane diterpenoids from Coleus forskohlii Briq. Bhat, SV; Bajwa, BS; Dornauer, H; de Souza, NJ; Fehlhaber, HW. Tetrahedron Letters. 1977. 19: 1669.

Potential medical use[edit]

Glaucoma and Forskolin.Dr. J. Caprioli.In: Rupp, RH; de Souza, NJ; Dohadwalla, AN.(Eds). Proceedings of an international symposium on "Forskolin: Its Chemical, Biological and Medical Potential", Hoechst India Limited, Bombay. 1985. pp. 153-174; Pharmacodynamics of Forskolin Eye-drops in healthy subjects. Dr. P.U.Witte. In: Rupp, RH; de Souza, NJ; Dohadwalla, AN.(Eds). Proceedings of an international symposium on "Forskolin: Its Chemical, Biological and Medical Potential", Hoechst India Limited, Bombay. 1985. pp. 175-182; Clinical Studies with Forskolin Eye-Drops in Patients with Open Angle Glaucoma. D. (Mrs.) L. Pinto-Pereira. In: Rupp, RH; de Souza, NJ; Dohadwalla, AN.(Eds). Proceedings of an international symposium on "Forskolin: Its Chemical, Biological and Medical Potential", Hoechst India Limited, Bombay. 1985. pp. 183 - 191;


The sometimes successful use of forskolin to reduce intraocular pressure may be due to its unique ability to stimulate adenylate cyclase activity and increase cAMP which regulates and activates critical enzymes required for the cellular energy required to move fluid out of the eye.

Forskolin can also be used to promote nerve repair by increasing cAMP concentrations. Forskolin can activate or upregulate the proliferation of Schwann cells in culture, together with Fibroblast growth factor or Transforming Growth Factor-Beta.

Various experimental studies are underway in using Forskolin as an adjuvant in treatment for diseases such as Parkinsons and/or nerve damage caused by trauma/accident.

References[edit]

  1. ^ "Forskolin" (pdf). Sigma Aldrich. 
  2. ^ Dewick, P. M. (2009). Medicinal Natural Products (3rd ed.). Wiley. p. 232. ISBN 978-0470741689. 
  3. ^ McEwan, D. G.; Brunton, V. G.; Baillie, G. S.; Leslie, N. R.; Houslay, M. D.; Frame, M. C. (2007). "Chemoresistant KM12C Colon Cancer Cells Are Addicted to Low Cyclic AMP Levels in a Phosphodiesterase 4-Regulated Compartment via Effects on Phosphoinositide 3-Kinase". Cancer Research 67 (11): 5248–5257. doi:10.1158/0008-5472.CAN-07-0097. PMID 17545604. 
  4. ^ Otmakhov, N.; Khibnik, L.; Otmakhova, N.; Carpenter, S.; Riahi, S.; Asrican, B.; Lisman, J. (2004). "Forskolin-Induced LTP in the CA1 Hippocampal Region Is NMDA Receptor Dependent". Journal of Neurophysiology 91 (1): 1955–1962. doi:10.1152/jn.00941.2003. PMID 14702333. 
  5. ^ Godard, M. P.; Johnson, B. A.; Richmond, S. R. (2005). "Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men". Obesity Research 13 (8): 1335–1343. doi:10.1038/oby.2005.162. PMID 16129715. 
  6. ^ Wagh VD, Patil PN, Surana SJ, Wagh KVForskolin: Upcoming antiglaucoma molecule. J Postgrad Med. 2012 Jul;58(3):199-202
  7. ^ English, J. (January 2000). "Research preview for the new millenium". Vitamin Research News. 
  8. ^ Zeng, S.; Shen, B.; Wen, L.; Hu, B.; Peng, D.; Chen, X.; Zhou, W. (1995). "Experimental studies of the effect of Forskolin on the lowering of intraocular pressure". Yan Ke Xue Bao (Eye Science) 11 (3): 173–176. PMID 8758848. 
  9. ^ Head, K. A. (2001). "Natural Therapies for Ocular Disorders, Part Two: Cataracts and Glaucoma". Alternative Medicine Review 6 (2): 141–166. PMID 11302779. 
  10. ^ Amaro-Ortiz, A. (2013). "Pharmacologic induction of epidermal melanin and protection against sunburn in a humanized mouse model.". J. Vis. Exp. (79). doi:10.3791/50670. PMID 24056496. 
  11. ^ "Herbal treatment Forskolin may help knock out for urinary tract infections once and for all". News Medical. 2007-04-08. 
  12. ^ Bishop BL. et al. (May 2007). "Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells.". Nat Med 13 (5): 625–30. doi:10.1038/nm1572. PMID 17417648. 

Further reading[edit]

External links[edit]