Fluticasone

From Wikipedia, the free encyclopedia - View original article

Fluticasone
Fluticasone.svg
Fluticasone ball-and-stick animation.gif
Systematic (IUPAC) name
S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-
6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-
6,7,8,11,12,14,15,16-octahydrocyclopenta[a]
phenanthrene-17-carbothioate
Clinical data
AHFS/Drugs.commonograph
Pregnancy cat.C for Intranasal and Inhaled
Legal statusPOM (UK) -only (US)
RoutesIntranasal, Inhaled, Topical Cream or Ointment
Pharmacokinetic data
Bioavailability0.51% (Intranasal)
Protein binding91%
MetabolismIntranasal
Hepatic (CYP3A4-mediated)
Half-life10 hours
ExcretionRenal
Identifiers
CAS number90566-53-3 N
80474-14-2 (propionate)
ATC codeD07AC17 R01AD08 R03BA05
PubChemCID 5311101
DrugBankDB00588
ChemSpider4470631 YesY
UNIICUT2W21N7U YesY
KEGGD07981 YesY
ChEBICHEBI:5134 N
ChEMBLCHEMBL1201396 N
Chemical data
FormulaC22H27F3O4S 
Mol. mass444.508 g/mol
 N (what is this?)  (verify)
 
Jump to: navigation, search
Not to be confused with fluconazole.
Fluticasone
Fluticasone.svg
Fluticasone ball-and-stick animation.gif
Systematic (IUPAC) name
S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-
6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-
6,7,8,11,12,14,15,16-octahydrocyclopenta[a]
phenanthrene-17-carbothioate
Clinical data
AHFS/Drugs.commonograph
Pregnancy cat.C for Intranasal and Inhaled
Legal statusPOM (UK) -only (US)
RoutesIntranasal, Inhaled, Topical Cream or Ointment
Pharmacokinetic data
Bioavailability0.51% (Intranasal)
Protein binding91%
MetabolismIntranasal
Hepatic (CYP3A4-mediated)
Half-life10 hours
ExcretionRenal
Identifiers
CAS number90566-53-3 N
80474-14-2 (propionate)
ATC codeD07AC17 R01AD08 R03BA05
PubChemCID 5311101
DrugBankDB00588
ChemSpider4470631 YesY
UNIICUT2W21N7U YesY
KEGGD07981 YesY
ChEBICHEBI:5134 N
ChEMBLCHEMBL1201396 N
Chemical data
FormulaC22H27F3O4S 
Mol. mass444.508 g/mol
 N (what is this?)  (verify)

Fluticasone is a synthetic glucocorticoid.[1]

Both the furoate and propionate forms are used as topical anti-inflammatories:[2]

See also[edit]

References[edit]

  1. ^ Briggs, Gerald G.; Freeman, Roger K.; Yaffe, Sumner J. (2012), Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, Lippincott Williams & Wilkins, p. 600, ISBN 1451153597. 
  2. ^ Spratto, George R.; Woods, Adrienne L. (2012), Delmar Nurse's Drug Handbook 2012, Cengage Learning, p. 748, ISBN 1111310653.