Flurbiprofen

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Flurbiprofen
Systematic (IUPAC) name
(RS)-2-(2-fluorobiphenyl-4-yl)propanoic acid
Clinical data
Trade namesAnsaid, Ocufen
AHFS/Drugs.commonograph
MedlinePlusa687005
Pregnancy cat.C (U.S.), B2 (Au)
Legal statusPOM
RoutesOral
Pharmacokinetic data
Protein binding> 99%
MetabolismHepatic (CYP2C9)
Half-life4.7-5.7 hours
ExcretionRenal
Identifiers
CAS number5104-49-4 YesY
ATC codeM01AE09 , M02AA19, R02AX01, S01BC04
PubChemCID 3394
IUPHAR ligand4194
DrugBankDB00712
ChemSpider3277 YesY
UNII5GRO578KLP YesY
KEGGD00330 YesY
ChEBICHEBI:5130 YesY
ChEMBLCHEMBL563 YesY
Synonyms(±)-2-fluoro-α-methyl-(1,1'-biphenyl)-4-acetic acid
Chemical data
FormulaC15H13FO2 
Mol. mass244.261 g/mol
Physical data
Melt. point117 °C (243 °F)
 YesY (what is this?)  (verify)
 
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Flurbiprofen
Systematic (IUPAC) name
(RS)-2-(2-fluorobiphenyl-4-yl)propanoic acid
Clinical data
Trade namesAnsaid, Ocufen
AHFS/Drugs.commonograph
MedlinePlusa687005
Pregnancy cat.C (U.S.), B2 (Au)
Legal statusPOM
RoutesOral
Pharmacokinetic data
Protein binding> 99%
MetabolismHepatic (CYP2C9)
Half-life4.7-5.7 hours
ExcretionRenal
Identifiers
CAS number5104-49-4 YesY
ATC codeM01AE09 , M02AA19, R02AX01, S01BC04
PubChemCID 3394
IUPHAR ligand4194
DrugBankDB00712
ChemSpider3277 YesY
UNII5GRO578KLP YesY
KEGGD00330 YesY
ChEBICHEBI:5130 YesY
ChEMBLCHEMBL563 YesY
Synonyms(±)-2-fluoro-α-methyl-(1,1'-biphenyl)-4-acetic acid
Chemical data
FormulaC15H13FO2 
Mol. mass244.261 g/mol
Physical data
Melt. point117 °C (243 °F)
 YesY (what is this?)  (verify)

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs) used to treat the inflammation and pain of arthritis.[1] It is known as "Ansaid" marketed by Pfizer and "Froben" by Abbott.

Flurbiprofen is also used as an active ingredient in some kinds of throat lozenges (Strepsils Intensive).

A single enantiomer of flurbiprofen, tarenflurbil [(R)-flurbiprofen)], is currently in clinical trials for the treatment of metastatic prostate cancer.

References[edit]

  1. ^ "Medical Dictionary, Houghton Mifflin Company". retrieved July 21, 2010.