Fluocinolone acetonide

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Fluocinolone acetonide
Fluocinolone acetonide.svg
Systematic (IUPAC) name
(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy cat.C
Legal statusPrescription Only
RoutesTopical
Pharmacokinetic data
MetabolismHepatic, CYP3A4-mediated
Half-life1.3 to 1.7 hours
Identifiers
CAS number67-73-2 YesY
ATC codeC05AA10 D07AC04 S01BA15 S02BA08
PubChemCID 6215
DrugBankDB00591
ChemSpider5980 YesY
UNII0CD5FD6S2M YesY
KEGGD01825 YesY
ChEBICHEBI:31623 N
ChEMBLCHEMBL989 YesY
Chemical data
FormulaC24H30F2O6 
Mol. mass452.488 g/mol
 N (what is this?)  (verify)
 
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Fluocinolone acetonide
Fluocinolone acetonide.svg
Systematic (IUPAC) name
(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy cat.C
Legal statusPrescription Only
RoutesTopical
Pharmacokinetic data
MetabolismHepatic, CYP3A4-mediated
Half-life1.3 to 1.7 hours
Identifiers
CAS number67-73-2 YesY
ATC codeC05AA10 D07AC04 S01BA15 S02BA08
PubChemCID 6215
DrugBankDB00591
ChemSpider5980 YesY
UNII0CD5FD6S2M YesY
KEGGD01825 YesY
ChEBICHEBI:31623 N
ChEMBLCHEMBL989 YesY
Chemical data
FormulaC24H30F2O6 
Mol. mass452.488 g/mol
 N (what is this?)  (verify)

Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.

Flucinolone is a group IV (0.01-0.2%) or group V (0.25%) corticosteroid under US classification.

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