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In the United States, Fiorinal is a combination analgesic medication consisting of aspirin, the barbiturate butalbital, and caffeine; in other countries the formulation may differ. For example, in Australia, Fiorinal consists of paracetamol, codeine phosphate, and the sedative antihistamine doxylamine. Some United States formulations also contain the opioid codeine. It is indicated for the treatment of tension headaches and is often used off-label (without approval by the U.S. Food and Drug Administration (FDA)) to treat migraines. The mechanism of action is not well understood. Since butalbital is habit-forming, using the United States Formulation of Fiorinal daily can lead to dependency. Fiorinal #3 contains: 30 mg codeine, 50 mg butalbital, 40 mg caffeine, and 325 mg aspirin.
Other brand names include Fiormor, Fiortal, Fortabs, and Laniroif.
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Watson Pharmaceuticals is the manufacturer.