Ficain

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Ficain
Identifiers
EC number3.4.22.3
CAS number9001-33-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
 
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Ficain
Identifiers
EC number3.4.22.3
CAS number9001-33-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Ficain (EC 3.4.22.3, ficin, debricin, higueroxyl delabarre) is an enzyme that is derived from figs latex.[1][2] It is of a family of proteases known as the cysteine endopeptidases, a group that also includes papain derived from papaya latex, bromelase (bromelain) extracted from pineapple stem, calpain, caspases, cathespisin B, and chymopapain. It is one of the most commonly used for differentiating many blood group antigens: For example, it destroys M, N, S, Duffy a, and Duffy b, and enhances some other antigens.

It is a common occurrence when eating the skins or the white pulp directly inside the skin of a fig to get a burning or itching sensation. This is due to the ficin in the latex (sap) of the fruit, particularly if it is unripened.

References[edit]

  1. ^ Liener, I.E. and Friedenson, B. (1970). "Ficin". Methods Enzymol. 19: 261–273. 
  2. ^ Brocklehurst, K., Willenbrock, F. and Salih, E. (1987). "Cysteine proteinases". In Neuberger, A. and Brocklehurst, K. New Comprehensive Biochemistry: Hydrolytic Enzymes. Amsterdam: Elsevier. pp. 39–158. 

External links[edit]