It is a common occurrence when eating the skins or the white pulp directly inside the skin of a fig to get a burning or itching sensation. This is due to the ficin in the latex (sap) of the fruit, particularly if it is unripened.
^Liener, I.E. and Friedenson, B. (1970). "Ficin". Methods Enzymol.19: 261–273.
^Brocklehurst, K., Willenbrock, F. and Salih, E. (1987). "Cysteine proteinases". In Neuberger, A. and Brocklehurst, K. New Comprehensive Biochemistry: Hydrolytic Enzymes. Amsterdam: Elsevier. pp. 39–158.