The song is formed around an open bluesy, metallic guitar tuning, with the tune opening with its chorus. It was one of the few Queen songs played in an alternative guitar tuning, being played in drop D tuning. The song's music video was filmed at the Dallas Convention Center in Texas in October 1978.
Queen performed "Fat Bottomed Girls" in concert between 1978 and 1982. Since its release, the song has appeared on television and film, and has been covered by a number of artists.
Vocal arrangements are quite different between the studio version and the live version. In live performances, the lead vocals during the chorus were sung by Freddie Mercury and harmonised with an upper voice (Roger Taylor) and a lower voice (Brian May). In the studio version, there is no higher harmony. The lead vocals on the verses are sung by Freddie Mercury, while Brian May sings lead on the chorus.
The single version (which can be found on Greatest Hits) omits the extended guitar interludes between the verses as well as fading out before the ending.
"Fat Bottomed Girls" was released as a double A-side with the song "Bicycle Race", and includes the line "Get on your bikes and ride". "Bicycle Race" contains the line "Fat bottomed girls, they'll be riding today, so look out for those beauties, oh yeah", completing a double cross-reference between the two songs.