FOLFOX

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FOLFOX is a chemotherapy regimen for treatment of colorectal cancer, made up of the drugs

FOLFOX4[edit source | edit]

Adjuvant treatment in patients with stage III colon cancer is recommended for 12 cycles, every 2 weeks. The recommended dose schedule given every two weeks is as follows:

Day 1: Oxaliplatin 85 mg/m² IV infusion in 250-500 mL D5W and leucovorin 200 mg/m² IV infusion in D5W both given over 120 minutes at the same time in separate bags using a Y-line, followed by 5-FU 400 mg/m² IV bolus given over 2-4 minutes, followed by 5-FU 600 mg/m² IV infusion in 500 mL D5W (recommended) as a 22-hour continuous infusion.

Day 2: Leucovorin 200 mg/m² IV infusion over 120 minutes, followed by 5-FU 400 mg/m² IV bolus given over 2-4 minutes, followed by 5-FU 600 mg/m² IV infusion in 500 mL D5W (recommended) as a 22-hour continuous infusion.

FOLFOX4 regime[2][3]
FOLFOX4
drugdoseadministrationtimeterm
Oxaliplatin85 mg/m²IV infusion2 hday 1
Folinic acid200 mg/m²IV infusion2 hday 1 + 2
Fluorouracil400 mg/m²IV bolus2 minday 1 + 2
Fluorouracil600 mg/m²IV infusion22 hday 1 + 2

Premedication with antiemetics, including 5-HT3 blockers with or without dexamethasone, is recommended.

See also[edit source | edit]

References[edit source | edit]

  1. ^ Cancer Research UK, CancerHelp UK
  2. ^ de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, Boni C, Cortes-Funes H, Cervantes A, Freyer G, Papamichael D, Le Bail N, Louvet C, Hendler D, de Braud F, Wilson C, Morvan F, Bonetti A (2000). "Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer". J Clin Oncol 18 (16): 2938–47. PMID 10944126.  HTML PDF Patients with advanced colorectal cancer were given 5-fluorouracil and leukovorin. Those who were also given oxaliplatin were more likely to have a response, and had longer progression-free survival, than patients without oxaliplatin. However, patients with oxaliplatin didn't survive any longer than patients without it.
  3. ^ FDA Approval: Eloxatin [oxaliplatin] PDF