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Adjuvant treatment in patients with stage III colon cancer is recommended for 12 cycles, every 2 weeks. The recommended dose schedule given every two weeks is as follows:
Day 1: Oxaliplatin 85 mg/m² IV infusion in 250-500 mL D5W and leucovorin 200 mg/m² IV infusion in D5W both given over 120 minutes at the same time in separate bags using a Y-line, followed by 5-FU 400 mg/m² IV bolus given over 2-4 minutes, followed by 5-FU 600 mg/m² IV infusion in 500 mL D5W (recommended) as a 22-hour continuous infusion.
Day 2: Leucovorin 200 mg/m² IV infusion over 120 minutes, followed by 5-FU 400 mg/m² IV bolus given over 2-4 minutes, followed by 5-FU 600 mg/m² IV infusion in 500 mL D5W (recommended) as a 22-hour continuous infusion.
|Oxaliplatin||85 mg/m²||IV infusion||2 h||day 1|
|Folinic acid||200 mg/m²||IV infusion||2 h||day 1 + 2|
|Fluorouracil||400 mg/m²||IV bolus||2 min||day 1 + 2|
|Fluorouracil||600 mg/m²||IV infusion||22 h||day 1 + 2|
Premedication with antiemetics, including 5-HT3 blockers with or without dexamethasone, is recommended.
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