FGR (gene)

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Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
Identifiers
SymbolsFGR; SRC2; c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr; p58c-fgr
External IDsOMIM164940 MGI95527 HomoloGene3842 ChEMBL: 4454 GeneCards: FGR Gene
EC number2.7.10.2
RNA expression pattern
PBB GE FGR 208438 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez226814191
EnsemblENSG00000000938ENSMUSG00000028874
UniProtP09769P14234
RefSeq (mRNA)NM_001042729NM_010208
RefSeq (protein)NP_001036194NP_034338
Location (UCSC)Chr 1:
27.94 – 27.96 Mb
Chr 4:
132.97 – 133 Mb
PubMed search[1][2]
 
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Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
Identifiers
SymbolsFGR; SRC2; c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr; p58c-fgr
External IDsOMIM164940 MGI95527 HomoloGene3842 ChEMBL: 4454 GeneCards: FGR Gene
EC number2.7.10.2
RNA expression pattern
PBB GE FGR 208438 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez226814191
EnsemblENSG00000000938ENSMUSG00000028874
UniProtP09769P14234
RefSeq (mRNA)NM_001042729NM_010208
RefSeq (protein)NP_001036194NP_034338
Location (UCSC)Chr 1:
27.94 – 27.96 Mb
Chr 4:
132.97 – 133 Mb
PubMed search[1][2]

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene.[1][2]

Function[edit]

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.[2]

Discovery[edit]

The feline version of this gene was discovered by Suraiya Rasheed, Murray Gardner, and co-workers.[3]

Interactions[edit]

FGR (gene) has been shown to interact with Wiskott-Aldrich syndrome protein.[4][5][6]

References[edit]

  1. ^ Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC (October 1985). "Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family". Proc. Natl. Acad. Sci. U.S.A. 82 (19): 6595–9. doi:10.1073/pnas.82.19.6595. PMC 391256. PMID 2995972. 
  2. ^ a b "Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog". 
  3. ^ Rasheed S, Barbacid M, Aaronson S, Gardner MB (February 1982). "Origin and biological properties of a new feline sarcoma virus". Virology 117 (1): 238–44. doi:10.1016/0042-6822(82)90522-0. PMID 6175084. 
  4. ^ Banin, S; Truong O, Katz D R, Waterfield M D, Brickell P M, Gout I (August 1996). "Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases". Curr. Biol. (ENGLAND) 6 (8): 981–8. doi:10.1016/S0960-9822(02)00642-5. ISSN 0960-9822. PMID 8805332. 
  5. ^ Finan, P M; Soames C J, Wilson L, Nelson D L, Stewart D M, Truong O, Hsuan J J, Kellie S (October 1996). "Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains". J. Biol. Chem. (UNITED STATES) 271 (42): 26291–5. doi:10.1074/jbc.271.42.26291. ISSN 0021-9258. PMID 8824280. 
  6. ^ Rivero-Lezcano, O M; Marcilla A, Sameshima J H, Robbins K C (October 1995). "Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains". Mol. Cell. Biol. (UNITED STATES) 15 (10): 5725–31. ISSN 0270-7306. PMC 230823. PMID 7565724. 

Further reading[edit]

  • Patel M, Faulkner L, Katz DR, Brickell PM (1991). "The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages.". Pathobiology 59 (4): 289–92. doi:10.1159/000163665. PMID 1652975. 
  • Resh MD (1994). "Myristylation and palmitylation of Src family members: the fats of the matter.". Cell 76 (3): 411–3. doi:10.1016/0092-8674(94)90104-X. PMID 8313462. 
  • Lowell CA, Berton G (1999). "Integrin signal transduction in myeloid leukocytes.". J. Leukoc. Biol. 65 (3): 313–20. PMID 10080533. 
  • Snapper SB, Rosen FS (1999). "The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization.". Annu. Rev. Immunol. 17 (1): 905–29. doi:10.1146/annurev.immunol.17.1.905. PMID 10358777. 
  • Tatosyan AG, Mizenina OA (2000). "Kinases of the Src family: structure and functions.". Biochemistry Mosc. 65 (1): 49–58. PMID 10702640. 
  • Patel MS, Mankoo BS, Brickell PM (1993). "A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1.". Hum. Mol. Genet. 1 (1): 65. doi:10.1093/hmg/1.1.65-a. PMID 1339476. 
  • Link DC, Gutkind SJ, Robbins KC, Ley TJ (1992). "Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter.". Oncogene 7 (5): 877–84. PMID 1373875. 
  • Patel M, Leevers SJ, Brickell PM (1990). "Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites.". Oncogene 5 (2): 201–6. PMID 1690869. 
  • Biondi A, Paganin C, Rossi V, et al. (1991). "Expression of lineage-restricted protein tyrosine kinase genes in human natural killer cells.". Eur. J. Immunol. 21 (3): 843–6. doi:10.1002/eji.1830210348. PMID 1826268. 
  • Gutkind JS, Link DC, Katamine S, et al. (1991). "A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes.". Mol. Cell. Biol. 11 (3): 1500–7. PMC 369433. PMID 1847500. 
  • Patel M, Leevers SJ, Brickell PM (1990). "Regulation of c-fgr proto-oncogene expression in Epstein-Barr virus infected B-cell lines.". Int. J. Cancer 45 (2): 342–6. doi:10.1002/ijc.2910450222. PMID 2154410. 
  • Parker RC, Mardon G, Lebo RV, et al. (1985). "Isolation of duplicated human c-src genes located on chromosomes 1 and 20.". Mol. Cell. Biol. 5 (4): 831–8. PMC 366788. PMID 2581127. 
  • Brickell PM, Patel M (1989). "Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines.". Br. J. Cancer 58 (6): 704–9. doi:10.1038/bjc.1988.294. PMC 2246855. PMID 2852026. 
  • Tronick SR, Popescu NC, Cheah MS, et al. (1985). "Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family.". Proc. Natl. Acad. Sci. U.S.A. 82 (19): 6595–9. doi:10.1073/pnas.82.19.6595. PMC 391256. PMID 2995972. 
  • Cheah MS, Ley TJ, Tronick SR, Robbins KC (1986). "fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection.". Nature 319 (6050): 238–40. doi:10.1038/319238a0. PMID 3003578. 
  • Nishizawa M, Semba K, Yoshida MC, et al. (1987). "Structure, expression, and chromosomal location of the human c-fgr gene.". Mol. Cell. Biol. 6 (2): 511–7. PMC 367540. PMID 3023853. 
  • Katamine S, Notario V, Rao CD, et al. (1988). "Primary structure of the human fgr proto-oncogene product p55c-fgr.". Mol. Cell. Biol. 8 (1): 259–66. PMC 363113. PMID 3275868. 
  • Inoue K, Ikawa S, Semba K, et al. (1988). "Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9.". Oncogene 1 (3): 301–4. PMID 3330776. 
  • Nishizawa M, Semba K, Yamamoto T, Toyoshima K (1985). "Human c-f gr gene does not contain coding sequence for actin-like protein.". Jpn. J. Cancer Res. 76 (3): 155–9. PMID 3922831.