This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.
The feline version of this gene was discovered by Suraiya Rasheed, Murray Gardner, and co-workers.
^Banin, S; Truong O; Katz D R; Waterfield M D; Brickell P M; Gout I (August 1996). "Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases". Curr. Biol. (ENGLAND) 6 (8): 981–8. doi:10.1016/S0960-9822(02)00642-5. ISSN0960-9822. PMID8805332.
^Finan, P M; Soames C J; Wilson L; Nelson D L; Stewart D M; Truong O; Hsuan J J; Kellie S (October 1996). "Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains". J. Biol. Chem. (UNITED STATES) 271 (42): 26291–5. doi:10.1074/jbc.271.42.26291. ISSN0021-9258. PMID8824280.
Patel M, Faulkner L, Katz DR, Brickell PM (1991). "The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages.". Pathobiology59 (4): 289–92. doi:10.1159/000163665. PMID1652975.
Tatosyan AG, Mizenina OA (2000). "Kinases of the Src family: structure and functions.". Biochemistry Mosc.65 (1): 49–58. PMID10702640.
Patel MS, Mankoo BS, Brickell PM (1993). "A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1.". Hum. Mol. Genet.1 (1): 65. doi:10.1093/hmg/1.1.65-a. PMID1339476.
Link DC, Gutkind SJ, Robbins KC, Ley TJ (1992). "Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter.". Oncogene7 (5): 877–84. PMID1373875.
Patel M, Leevers SJ, Brickell PM (1990). "Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites.". Oncogene5 (2): 201–6. PMID1690869.
Biondi A, Paganin C, Rossi V, et al. (1991). "Expression of lineage-restricted protein tyrosine kinase genes in human natural killer cells.". Eur. J. Immunol.21 (3): 843–6. doi:10.1002/eji.1830210348. PMID1826268.