Eucalyptus oil

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Eucalyptus oil for pharmaceutical use.

Eucalyptus oil is the generic name for distilled oil from the leaf of Eucalyptus, a genus of the plant family Myrtaceae native to Australia and cultivated worldwide. Eucalyptus oil has a history of wide application, as a pharmaceutical, antiseptic, repellent, flavouring, fragrance and industrial uses. The leaves of selected Eucalyptus species are steam distilled to extract eucalyptus oil.

Types and production[edit]

Eucalyptus oils in the trade are categorized into three broad types according to their composition and main end-use: medicinal, perfumery and industrial.[1] The most prevalent is the standard cineole-based "oil of eucalyptus", a colourless mobile liquid (yellow with age) with a penetrating, camphoraceous, woody-sweet scent.[2]

China produces about 75% of the world trade, but most of this is derived from camphor oil fractions rather than being true eucalyptus oil.[3] Significant producers of true eucalyptus oil include South Africa, Portugal, Spain, Brazil, Australia, Chile and Swaziland.

Eucalyptus polybractea or Blue-leaf Mallee, a species yielding high quality eucalyptus oil

Global production is dominated by Eucalyptus globulus. However, Eucalyptus kochii and Eucalyptus polybractea have the highest cineole content, ranging from 80-95%. The British Pharmacopoeia states that the oil must have a minimum cineole content of 70% if it is pharmaceutical grade. Rectification is used to bring lower grade oils up to the high cineole standard required. Global annual production of eucalyptus oil is estimated at 3,000 tonnes.[4] The eucalyptus genus also produces non-cineole oils, including piperitone, phellandrene, citral, methyl cinnamate and geranyl acetate.

Eucalyptus oil should not be confused with the term "eucalyptol", another name for cineole.

Uses[edit]

Medicinal and antiseptic[edit]

The cineole-based oil is used as component in pharmaceutical preparations to relieve the symptoms of influenza and colds, in products like cough sweets, lozenges, ointments and inhalants. Eucalyptus oil has antibacterial effects on pathogenic bacteria in the respiratory tract.[5] Inhaled eucalyptus oil vapor is a decongestant and treatment for bronchitis.[6] Cineole controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition.[7][8] Eucalyptus oil also stimulates immune system response by effects on the phagocytic ability of human monocyte derived macrophages.[9]

Eucalyptus oil also has anti-inflammatory and analgesic qualities as a topically applied liniment ingredient.[10][11]

Eucalyptus oil is also used in personal hygiene products for antimicrobial properties in dental care[12] and soaps. It can also be applied to wounds to prevent infection.

Repellent and biopesticide[edit]

Cineole-based eucalyptus oil is used as an insect repellent and biopesticide. In the U.S., eucalyptus oil was first registered in 1948 as an insecticide and miticide.[13]

Flavouring[edit]

Eucalyptus oil is used in flavouring. Cineole-based eucalyptus oil is used as a flavouring at low levels (0.002%) in various products, including baked goods, confectionery, meat products and beverages.[14] Eucalyptus oil has antimicrobial activity against a broad range of foodborne human pathogens and food spoilage microorganisms.[15] Non-cineole peppermint gum, strawberry gum and lemon ironbark are also used as flavouring.

Fragrance[edit]

Eucalyptus oil is also used as a fragrance component to impart a fresh and clean aroma in soaps, detergents, lotions and perfumes.

Industrial[edit]

Research shows that cineole-based eucalyptus oil (5% of mixture) prevents the separation problem with ethanol and petrol fuel blends. Eucalyptus oil also has a respectable octane rating and can be used as a fuel in its own right. However, production costs are currently too high for the oil to be economically viable as a fuel.[16]

Phellandrene- and piperitone-based eucalyptus oils have been used in mining to separate sulfide minerals via flotation.

Safety and toxicity[edit]

If consumed internally at low dosage as a flavouring component or in pharmaceutical products at the recommended rate, cineole-based 'oil of eucalyptus' is safe for adults. However, systemic toxicity can result from ingestion or topical application at higher than recommended doses.[17]

The probable lethal dose of pure eucalyptus oil for an adult is in the range of 0.05 mL to 0.5 mL/per kg of body weight.[18] Because of their high body surface area to mass ratio, children are more vulnerable to poisons absorbed transdermally. Severe poisoning has occurred in children after ingestion of 4 mL to 5 mL of eucalyptus oil.[19]

History[edit]

Australian Aboriginals use eucalyptus leaf infusions (which contain eucalyptus oil) as a traditional medicine for treating body pains, sinus congestion, fever, and colds.[20][21]

Dennis Considen and John White, surgeons on the First Fleet, distilled eucalyptus oil from Eucalyptus piperita found growing on the shores of Port Jackson in 1788 to treat convicts and marines.[22][23][24][25] Eucalyptus oil was subsequently extracted by early colonists, but was not commercially exploited for some time.

Baron Ferdinand von Mueller, Victorian botanist, promoted the qualities of Eucalyptus as a disinfectant in "fever districts", and also encouraged Joseph Bosisto, a Melbourne pharmacist, to investigate the commercial potential of the oil.[26] Bosisto started the commercial eucalyptus oil industry in 1852 near Dandenong, Victoria, Australia, when he set up a distillation plant and extracted the essential oil from the cineole chemotype of Eucalyptus radiata. This resulted in the cineole chemotype becoming the generic 'oil of eucalyptus', and "Bosisto's Eucalyptus Oil" still survives as a brand.

French chemist, F.S. Cloez, identified and ascribed the name eucalyptol — also known as cineole — to the dominant portion of E. globulus oil.[27] By the 1870s oil from Eucalyptus globulus, Tasmanian blue gum, was being exported worldwide and eventually dominated world trade, while other higher quality species were also being distilled to a lesser extent. Surgeons were using eucalyptus oil as an antiseptic during surgery by the 1880s.[28]

The Australian eucalyptus oil industry peaked in the 1940s, the main area of production being the central goldfields region of Victoria, particularly Inglewood; then the global establishment of eucalyptus plantations for timber resulted in increased volumes of eucalyptus oil as a plantation by-product. By the 1950s the cost of producing eucalyptus oil in Australia had increased so much that it could not compete against cheaper Spanish and Portuguese oils (closer to European Market therefore less costs). Non-Australian sources now dominate commercial eucalyptus oil supply, although Australia continues to produce high grade oils, mainly from blue mallee (E. polybractea) stands.

Species utilised[edit]

Commercial cineole-based eucalyptus oils are produced from several species of Eucalyptus:

Non-cineole oil producing species:

The former lemon eucalyptus species Eucalyptus citriodora is now classified as Corymbia citriodora, which produces a citronellal-based oil.

Compendial status[edit]

See also[edit]

References[edit]

  1. ^ William M. Ciesla. "Types of oil and uses". Non-wood Forest Products from Temperate Broad-leaved Trees. Food & Agriculture Org (2002). p. 30. 
  2. ^ Lawless, J., The Illustrated Encyclopedia of Essential Oils, Element Books 1995 ISBN 1-85230-661-0
  3. ^ Ashurst, P. R (1999-07-31). Food Flavorings. ISBN 9780834216211. 
  4. ^ FOA
  5. ^ Salari, M. H.; Amine, G.; Shirazi, M. H.; Hafezi, R.; Mohammadypour, M. (2006). "Antibacterial effects of Eucalyptus globulus leaf extract on pathogenic bacteria isolated from specimens of patients with respiratory tract disorders". Clinical Microbiology and Infection 12 (2): 194–6. doi:10.1111/j.1469-0691.2005.01284.x. PMID 16441463. 
  6. ^ Lu, XQ; Tang, FD; Wang, Y; Zhao, T; Bian, RL (2004). "Effect of Eucalyptus globulus oil on lipopolysaccharide-induced chronic bronchitis and mucin hypersecretion in rats". Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 29 (2): 168–71. PMID 15719688. 
  7. ^ Juergens, U.R; Dethlefsen, U; Steinkamp, G; Gillissen, A; Repges, R; Vetter, H (2003). "Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: A double-blind placebo-controlled trial". Respiratory Medicine 97 (3): 250–6. doi:10.1053/rmed.2003.1432. PMID 12645832. 
  8. ^ Juergens, Uwe R.; Engelen, Tanja; Racké, Kurt; Stöber, Meinolf; Gillissen, Adrian; Vetter, Hans (2004). "Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes". Pulmonary Pharmacology & Therapeutics 17 (5): 281. doi:10.1016/j.pupt.2004.06.002. 
  9. ^ Serafino, A; Sinibaldi Vallebona, PS; Andreola, F; Zonfrillo, M; Mercuri, L; Federici, M; Rasi, G; Garaci, E; Pierimarchi, P (2008). "Stimulatory effect of Eucalyptus essential oil on innate cell-mediated immune response". BMC Immunology 9: 17. doi:10.1186/1471-2172-9-17. PMC 2374764. PMID 18423004. 
  10. ^ Göbel, H; Schmidt, G; Soyka, D (1994). "Effect of peppermint and eucalyptus oil preparations on neurophysiological and experimental algesimetric headache parameters". Cephalalgia : an international journal of headache 14 (3): 228–34; discussion 182. doi:10.1046/j.1468-2982.1994.014003228.x. PMID 7954745. 
  11. ^ Hong, CZ; Shellock, FG (1991). "Effects of a topically applied counterirritant (Eucalyptamint) on cutaneous blood flow and on skin and muscle temperatures. A placebo-controlled study". American journal of physical medicine & rehabilitation / Association of Academic Physiatrists 70 (1): 29–33. doi:10.1097/00002060-199102000-00006. PMID 1994967. 
  12. ^ Nagata, Hideki; Inagaki, Yoshika; Tanaka, Muneo; Ojima, Miki; Kataoka, Kosuke; Kuboniwa, Masae; Nishida, Nobuko; Shimizu, Katsumasa; Osawa, Kenji; Shizukuishi, Satoshi (2008). "Effect of Eucalyptus Extract Chewing Gum on Periodontal Health: A Double-Masked, Randomized Trial". Journal of Periodontology 79 (8): 1378–85. doi:10.1902/jop.2008.070622. PMID 18672986. 
  13. ^ Flower and Vegetable Oils, R.E.D. Facts, EPA
  14. ^ Harborne, J.B., Baxter, H., Chemical Dictionary of Economic Plants, ISBN 0-471-49226-4
  15. ^ Zhao, J., Agboola, S., Functional Properties of Australian Bushfoods - A Report for the Rural Industries Research and Development Corporation, 2007, RIRDC Publication No 07/030
  16. ^ Boland, D.J., Brophy, J.J., and A.P.N. House, Eucalyptus Leaf Oils, 1991, p. 8 ISBN 0-909605-69-6
  17. ^ Darben, T; Cominos, B; Lee, CT (1998). "Topical eucalyptus oil poisoning". The Australasian journal of dermatology 39 (4): 265–7. doi:10.1111/j.1440-0960.1998.tb01488.x. PMID 9838728. 
  18. ^ Hindle, R.C. (1994). "Eucalyptus oil ingestion". New Zealand Medical Journal: 185–186. 
  19. ^ Foggie, WE (1911). "Eucalyptus Oil Poisoning". British Medical Journal 1 (2616): 359–360. doi:10.1136/bmj.1.2616.359. PMC 2332914. PMID 20765463. 
  20. ^ Low, T., Bush Medicine, A Pharmacopeia of Natural Remedies, Angus & Robertson, p. 85, 1990.
  21. ^ Barr, A., Chapman, J., Smith, N., Beveridge, M., Traditional Bush Medicines, An Aboriginal Pharmacopoeia, Greenhouse Publications, pp. 116–117, 1988, ISBN 086436167X
  22. ^ Maiden, J.H., The Forest Flora of New South Wales, vol. 4, Government Printer, Sydney, 1922.
  23. ^ Copy of letter received by Dr Anthony Hamiltion, from Dennis Considen, 18 November 1788, and sent onto Joseph Banks.
  24. ^ Lassak, E.V., & McCarthy, T., Australian Medicinal Plants, Methuen Australia, 1983, p. 15, ISBN 0-454-00438-9.
  25. ^ White, J., Journal of a Voyage to New South Wales, 1790
  26. ^ Grieve, M.,(author) & Leyel, C.F., (ed), A Modern Herbal, Jonathon Cape, 1931, p. 287.
  27. ^ Boland, D.J., Brophy, J.J., and A.P.N. House, Eucalyptus Leaf Oils, 1991, p. 6 ISBN 0-909605-69-6
  28. ^ Maiden, J.H., The Useful Native Plants of Australia, pp. 255, 1889
  29. ^ The British Pharmacopoeia Secretariat (2009). "Index, BP 2009". Retrieved 10 September 2009. 

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