Ergocalciferol

From Wikipedia, the free encyclopedia - View original article

Ergocalciferol
Identifiers
CAS number50-14-6 YesY
PubChem5280793
ChemSpider4444351 YesY
UNIIVS041H42XC YesY
DrugBankDB00153
KEGGC05441 YesY
ChEBICHEBI:28934 YesY
ChEMBLCHEMBL1536 YesY
ATC codeA11CC01
Jmol-3D imagesImage 1
Properties
Molecular formulaC28H44O
Molar mass396.65 g/mol
Melting point

114–118 °C

 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references
 
Jump to: navigation, search
Ergocalciferol
Identifiers
CAS number50-14-6 YesY
PubChem5280793
ChemSpider4444351 YesY
UNIIVS041H42XC YesY
DrugBankDB00153
KEGGC05441 YesY
ChEBICHEBI:28934 YesY
ChEMBLCHEMBL1536 YesY
ATC codeA11CC01
Jmol-3D imagesImage 1
Properties
Molecular formulaC28H44O
Molar mass396.65 g/mol
Melting point

114–118 °C

 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Ergocalciferol is a provitamin form of vitamin D, also called vitamin D2. In isolated manufactured formats, it is marketed under various names including Deltalin (Eli Lilly and Company), Drisdol (Sanofi-Synthelabo), and Calcidol (Patrin Pharma). Ergocalciferol is created when ultraviolet light activates ergosterol.[citation needed]

Ergocalciferol may be used as a vitamin D supplement, and a 2011 clinical guideline[1] considered it to be as effective as cholecalciferol (vitamin D3), which is produced naturally by the skin when exposed to ultraviolet light.

Conflicting evidence exists for how similarly D2 and D3 behave in the body and whether they are equally active or efficient in production of 25-hydroxyvitamin D (25(OH)D), the active hormone. Some preliminary studies indicate D3 is more potent,[2][3] while others report equal efficacy.[1][4][5] While both appear to have similar efficacy in ameliorating rickets,[6] vitamin D3 may have more potency for reducing falls in elderly patients.[citation needed] The metabolism of each is different, with the vitamin D binding protein (VDP) possibly having greater affinity for 25(OH)D3 than for 25(OH)D2, as shown in one study.[2] Cholecalciferol (vitamin D3) is sensitive to UV radiation and rapidly, but reversibly, forms other sterols which can further irreversibly convert to ergosterol.[citation needed]

Sources[edit]

Lichen

Fungus, from USDA nutrient database[8]

Plantae

Ergocalciferol is produced in fungi synthetically through irradiation of ergosterol.[10] Human bioavailability of vitamin D2 from vitamin D2-enhanced button mushrooms via UV-B irradiation is effective in improving vitamin D status and not different to a vitamin D2 supplement.[11] Vitamin D2 from UV-irradiated yeast baked into bread is bioavailable.[12] By visual assessment or using a chromometer, no significant discoloration of irradiated mushrooms, as measured by the degree of "whiteness", was observed.[13] Claims have been made that a normal serving (approx. 3 oz or 1/2 cup, or 60 grams) of mushrooms treated with ultraviolet light provides vitamin D content to levels of 3,476 IU if exposed to just 5 minutes of UV light after being harvested.[14]

Preliminary research[edit]

One study found low vitamin D2 levels in patients with Alzheimer's disease,[15] but this observational study did not prove cause or effect related to ergocalciferol and vitamin D2 deficiency in the diet.

References[edit]

  1. ^ a b Holick, M. F.; Binkley, N. C.; Bischoff-Ferrari, H. A.; Gordon, C. M.; Hanley, D. A.; Heaney, R. P.; Murad, M. H.; Weaver, C. M. (2011). "Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline". Journal of Clinical Endocrinology & Metabolism 96 (7): 1911–1930. doi:10.1210/jc.2011-0385. PMID 21646368.  edit
  2. ^ a b Houghton, L.; Vieth, R. (2006). "The case against ergocalciferol (vitamin D2) as a vitamin supplement". The American Journal of Clinical Nutrition 84 (4): 694–697. PMID 17023693.  edit
  3. ^ Trang, H. M.; Cole, D. E.; Rubin, L. A.; Pierratos, A.; Siu, S.; Vieth, R. (1998). "Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2". The American journal of clinical nutrition 68 (4): 854–858. PMID 9771862.  edit
  4. ^ Holick, M. F.; Biancuzzo, R. M.; Chen, T. C.; Klein, E. K.; Young, A.; Bibuld, D.; Reitz, R.; Salameh, W.; Ameri, A.; Tannenbaum, A. D. (2007). "Vitamin D2 is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 25-Hydroxyvitamin D". Journal of Clinical Endocrinology & Metabolism 93 (3): 677–681. doi:10.1210/jc.2007-2308. PMC 2266966. PMID 18089691.  edit
  5. ^ Biancuzzo, R. M.; Young, A.; Bibuld, D.; Cai, M. H.; Winter, M. R.; Klein, E. K.; Ameri, A.; Reitz, R.; Salameh, W.; Chen, T. C.; Holick, M. F. (2010). "Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults". American Journal of Clinical Nutrition 91 (6): 1621–1626. doi:10.3945/ajcn.2009.27972. PMC 2869510. PMID 20427729.  edit
  6. ^ Thacher, TD; Fischer, PR; Obadofin, MO; Levine, MA; Singh, RJ; Pettifor, JM (2010). "Comparison of Metabolism of Vitamins D2 and D3 in Children with Nutritional Rickets". Journal of Bone and Mineral Research 25 (9): 1988–1995. doi:10.1002/jbmr.99. PMC 3153403. PMID 20499377. 
  7. ^ Wang, T; Bengtsson, G; Kärnefelt, I; Björn, LO (2001). "Provitamins and vitamins D₂and D₃in Cladina spp. Over a latitudinal gradient: Possible correlation with UV levels". Journal of photochemistry and photobiology. B, Biology 62 (1–2): 118–22. doi:10.1016/S1011-1344(01)00160-9. PMID 11693362. 
  8. ^ "USDA nutrient database – use the keyword 'portabella' and then click submit". 
  9. ^ "Dr. Duke's Phytochemical and Ethnobotanical Databases". 
  10. ^ "Vitamin D: A Rapid Review: Vitamin D2 and/or Vitamin D3". Medscape.com. 2008-06-30. Retrieved 2012-08-29. 
  11. ^ http://www.nature.com/ejcn/journal/v65/n8/full/ejcn201153a.html
  12. ^ Hohman, E. E.; Martin, B. R.; Lachcik, P. J.; Gordon, D. T.; Fleet, J. C.; Weaver, C. M. (2011). "Bioavailability and Efficacy of Vitamin D2from UV-Irradiated Yeast in Growing, Vitamin D-Deficient Rats". Journal of Agricultural and Food Chemistry 59 (6): 2341–2346. doi:10.1021/jf104679c. PMC 3235799. PMID 21332187.  edit
  13. ^ Koyyalamudi, SR; Jeong, SC; Song, CH; Cho, KY; Pang, G (2009). "Vitamin D2 formation and bioavailability from Agaricus bisporus button mushrooms treated with ultraviolet irradiation". J Agric Food Chem 57 (8): 3351–5. doi:10.1021/jf803908q. PMID 19281276. 
  14. ^ "Bringing Mushrooms Out of the Dark". MSNBC. April 18, 2006. Retrieved 2007-08-06. 
  15. ^ Iltaf Shah; Petroczi, Andrea; Tabet, Naji; Klugman, Anthony; Isaac, Mokhtar; p. Naughton, Declan (2012). "Low 25OH Vitamin D2 Levels Found in Untreated Alzheimer's Patients, Compared to Acetylcholinesterase-Inhibitor Treated and Controls". Current Alzheimer Research 9 (9): 1069–1076. doi:10.2174/156720512803568975. ISSN 1567-2050. PMID 22876849 

External links[edit]