Spinal anaesthesia is a technique whereby a local anaesthetic drug is injected into the cerebrospinal fluid. This technique has some similarity to epidural anaesthesia, and lay people often confuse the two techniques. Important differences include:
To achieve epidural analgesia or anaesthesia, a larger dose of drug is typically necessary than with spinal analgesia or anaesthesia.
The onset of analgesia is slower with epidural analgesia or anaesthesia than with spinal analgesia or anaesthesia.
It is easier to achieve segmental analgesia or anaesthesia using the epidural route than using the spinal route.
An indwelling catheter is more commonly placed in the setting of epidural analgesia or anaesthesia than with spinal analgesia or anaesthesia.
Injecting medication into the epidural space is primarily performed for analgesia. This may be performed using a number of different techniques and for a variety of reasons. Additionally, some of the side-effects of epidural analgesia may be beneficial in some circumstances (e.g., vasodilation may be beneficial if the subject has peripheral vascular disease). When a catheter is placed into the epidural space (see below) a continuous infusion can be maintained for several days, if needed. Epidural analgesia may be used:
For analgesia alone, where surgery is not contemplated. An epidural injection or infusion for pain relief (e.g. in childbirth) is less likely to cause loss of muscle power, but has to be augmented to be sufficient for surgery.
As an adjunct to general anaesthesia. The anaesthetist may use epidural analgesia in addition to general anaesthesia. This may reduce the patient's requirement for opioid analgesics. This is suitable for a wide variety of surgery, for example gynaecological surgery (e.g. hysterectomy), orthopaedic surgery (e.g. hip replacement), general surgery (e.g. laparotomy) and vascular surgery (e.g. open aortic aneurysm repair).
As a sole technique for surgical anaesthesia. Some operations, most frequently Caesarean section, may be performed using an epidural anaesthetic as the sole technique. This can allow the patient to remain awake during the operation. The dose required for anaesthesia is much higher than that required for analgesia.
For post-operative analgesia, after an operation where the epidural technique was used as either the sole anaesthetic, or was used in combination with general anaesthesia. Analgesics are given into the epidural space typically for a few days after surgery, provided a catheter has been inserted. Through the use of a patient-controlled epidural analgesia (PCEA) infusion pump, a person has the ability to give themselves an occasional dose of pain medication through an epidural catheter.
For the treatment of back pain. Injection of analgesics and steroids into the epidural space may improve some forms of back pain. See below.
For the treatment of chronic pain or palliation of symptoms in terminal care, usually in the short- or medium-term.
The epidural space is more difficult and risky to access as one ascends the spine (because the spinal cord gains more nerves as it ascends and fills the epidural space leaving less room for error), so epidural techniques are most suitable for analgesia anywhere in the lower body and as high as the chest. They are (usually) much less suitable for analgesia for the neck, or arms and are not possible for the head (since sensory innervation for the head arises directly from the brain via cranial nerves rather than from the spinal cord via the epidural space.)
There are circumstances where the risks of an epidural injection are higher than usual. These circumstances include:
Sagittal section of the spinal column (not drawn to scale). The spinal cord (yellow core) is in intimate contact with the pia mater (blue). The arachnoid (red) exists superficial to the pia mater, and is attached to it by many trabeculae, giving it a spider-like appearance. This space (light blue) is filled with cerebrospinal fluid (CSF) and is called the subarachnoid space. Superficial to the arachnoid is the dura mater (pink) and although they are unattached, they are kept firmly pressed against one another because of pressure exerted by the CSF. Superficial to the dura mater is a space (pale green), known as the epidural space, that exists between it and the internal surfaces of the vertebral bones and their supporting ligamentous structures. This space is likewise pressed closed by surrounding tissue pressure, so it is called a 'potential' space. The vertebral bones (taupe) are attached to one another by the interspinous ligaments (teal).
The epidural space is the space inside the bony spinal canal but just outside the dura mater ("dura"). In contact with the inner surface of the dura is another membrane called the arachnoid mater ("arachnoid"). The cerebrospinal fluid that surrounds the spinal cord is contained by the arachnoid mater. In adults, the spinal cord terminates around the level of the disc between L1 and L2 (in neonates it extends to L3 but can reach as low as L4), below which lies a bundle of nerves known as the cauda equina ("horse's tail"). Hence, lumbar epidural injections carry a low risk of injuring the spinal cord.
Insertion of an epidural needle involves threading a needle between the bones, through the ligaments and into the epidural potential space taking great care to avoid puncturing the layer immediately below containing CSF under pressure.
Procedures involving injection of any substance into the epidural space require the operator to be technically proficient in order to avoid complications.
The subject may be in the seated, lateral or prone positions. The level of the spine at which the catheter is best placed depends mainly on the site and type of an intended operation or the anatomical origin of pain. The iliac crest is a commonly used anatomical landmark for lumbar epidural injections, as this level roughly corresponds with the fourth lumbar vertebra, which is usually well below the termination of the spinal cord. The Tuohy needle is usually inserted in the midline, between the spinous processes. When using a paramedian approach, the tip of the needle passes along a shelf of vertebral bone called the lamina until just before reaching the ligamentun flavum and the epidural space.
Along with a sudden loss of resistance to pressure on the plunger of the syringe, a slight clicking sensation may be felt by the operator as the tip of the needle breaches the ligamentum flavum and enters the epidural space. Practitioners commonly use air or saline for identifying the epidural space. However, evidence is accumulating that saline is preferable to air, as it associated with a better quality of analgesia and lower incidence of post-dural-puncture headache. In addition to the loss of resistance technique, realtime observation of the advancing needle is becoming more common. This may be done using a portable ultrasound scanner, or with fluoroscopy (moving X-ray pictures).
After placement of the tip of the needle into the epidural space, a catheter is often threaded through the needle. The needle is then withdrawn over the catheter. Generally the catheter is inserted 4–6 cm into the epidural space. The catheter is typically secured to the skin with adhesive tape or dressings to prevent it becoming dislodged.
The catheter is a fine plastic tube, through which anaesthetics may be injected into the epidural space. Many epidural catheters have a blind end but have three or more orifices along the shaft near the distal tip (far end) of the catheter. This not only disperses the injected agents more widely around the catheter, but also reduces the incidence of catheter blockage.
For a short procedure, the anaesthetist may introduce a single dose of medication (the "bolus" technique). This will eventually dissipate. Thereafter, the anaesthetist may repeat the bolus provided the catheter remains undisturbed. For a prolonged effect, a continuous infusion of drugs may be employed. There is some evidence that an automated intermittent bolus technique provides better analgesia than a continuous infusion technique, though the total doses are identical.
Level and intensity of block Typically, the effects of the epidural block are noted below a specific level on the body. This level may be determined by the anaesthetist. A high insertion level may result in sparing of nerve function in the lower spinal nerves. For example, a thoracic epidural may be performed for upper abdominal surgery, but may not have any effect on the perineum (area around the genitals) or pelvic organs. Nonetheless, giving very large volumes into the epidural space may spread the block both higher and lower.
The intensity of the block is determined by the concentration of local anaesthetic solution used. For example, 0.1% bupivacaine may provide adequate analgesia for a woman in labour, but would likely be insufficient for surgical anaesthesia. Conversely, 0.5% bupivacaine would provide a more intense block, likely sufficient for surgery.
Removing the catheter
The catheter is usually removed when the subject is able to take oral pain medications. Catheters can safely remain in place for several days with little risk of bacterial infection, particularly if the skin is prepared with a chlorhexidine solution. Subcutaneously tunneled epidural catheters may be left in place for longer periods, with a low risk of infection or other complications.
Epidural analgesia during childbirth
Epidural analgesia provides rapid pain relief in most cases. It is more effective than nitrous oxide, opioids, TENS, and other common modalities of analgesia in childbirth. Epidurals during childbirth are the most commonly used anesthesia in this situation. The medication levels are very low to decrease the side effects to both mother and baby. When in labor the mother does not usually feel pain after and epidural but they do still feel the pressure. Women are able to bear down and push with contractions. Epidural clonidine has been extensively studied for management of analgesia during labour. Epidural analgesia is a relatively safe method of relieving pain in labour. In a 2011 Cochrane review which included 38 randomized controlled studies involving 9658 women, wherein all but five studies compared epidural analgesia with opiates, epidural analgesia in childbirth was associated with the following advantages and disadvantages:
However, the review found no difference in overall Caesarean delivery rates, nor were there effects on the baby soon after birth. Also, the occurrence of long-term backache was no different whether an epidural was or was not used.
Though complications are rare, some women and their babies will experience them. Some side effects for the mother include headaches, dizziness, difficulty breathing and seizures. The child may experience slowed heartbeat, temperature regulation issues and there could be high levels of drugs in the babies system from the epidural. 
Differing outcomes in frequency of Cesarean section may be explained by differing institutions or their practitioners: epidural anaesthesia and analgesia administered at top-rated institutions does not generally result in a clinically significant increase in caesarean rates, whereas the risk of caesarean delivery at poorly ranked facilities seems to increase with the use of epidural.
One study concluded that women whose epidural infusions contained fentanyl were less likely to fully breastfeed their infant in the few days after birth and more likely to stop breastfeeding in the first 24 weeks. However, this study has been criticised for several reasons, one of which is that the original patient records were not examined in this study, and so many of the epidural infusions were assumed to contain fentanyl when almost certainly they would not have. In addition, all those who had received epidural infusions in this study had also received systemic pethidine, which would be much more likely to be the cause of any effect on breastfeeding due to the higher amounts of medication used via that route. If this were the case, then early epidural analgesia which avoided the need for pethidine would be expected to improve breastfeeding outcomes rather than worsen them. Traditional epidural for labour relieves pain reliably only during first stage of labour (uterine contractions till cervix is fully open). It does not relieve pain as reliably during the second stage of labour( passage of the fetus through the vagina).
Epidural analgesia after surgery
Epidural analgesia has been demonstrated to have several benefits after surgery, including:
Effective analgesia without the need for systemic opioids.
The incidence of postoperative respiratory problems and chest infections is reduced.
Despite these benefits, no survival benefit has been proven for high-risk individuals.
Caudal epidural analgesia
The caudal approach to the epidural space involves the use of a Tuohy needle, an intravenous catheter, or a hypodermic needle to puncture the sacrococcygeal membrane. Injecting local anaesthetic at this level can result in analgesia and/or anaesthesia of the perineum and groin areas. The caudal epidural technique is often used in infants and children undergoing surgery involving the groin, pelvis or lower extremities. In this population, caudal epidural analgesia is usually combined with general anaesthesia since most children do not tolerate surgery when regional anaesthesia is employed as the sole modality.
For some procedures, the anaesthetist may choose to combine the rapid onset and reliable, dense block of a spinal anaesthetic with the post-operative analgesic effects of an epidural. This is called combined spinal and epidural anaesthesia (CSE). The practitioner may insert the spinal anaesthetic at one level, and the epidural at an adjacent level. Alternatively, after locating the epidural space with the Tuohy needle, a spinal needle may be inserted through the Tuohy needle into the subarachnoid space. The spinal dose is then given, the spinal needle withdrawn, and the epidural catheter inserted as normal. This method, known as the "needle-through-needle" technique, may be associated with a slightly higher risk of placing the catheter into the subarachnoid space.
In addition to blocking the nerves which carry pain, local anaesthetic drugs in the epidural space will block other types of nerves as well, in a dose-dependent manner. Depending on the drug and dose used, the effects may last only a few minutes or up to several hours. Epidural analgesia typically involves using the opiates fentanyl or sufentanil, with bupivacaine or one of its congeners. Fentanyl is a powerful opioid with a potency 80 times that of morphine and side effects common to the opiate class. Sufentanil is another opiate, 5 to 10 times more potent than Fentanyl. Bupivacaine is markedly toxic if inadvertently given intravenously, causing excitation, nervousness, tingling around the mouth, tinnitus, tremor, dizziness, blurred vision, or seizures, followed by depression: drowsiness, loss of consciousness, respiratory depression and apnea. Bupivacaine has caused several deaths by cardiac arrest when epidural anaesthetic has been accidentally inserted into a vein instead of the epidural space.
Sensory nerve fibers are more sensitive to the effects of the local anaesthetics than motor nerve fibers. This means that an epidural can provide analgesia while affecting muscle strength to a lesser extent. For example, a labouring woman may have a continuous epidural during labour that provides good analgesia without impairing her ability to move. If she requires a Caesarean section, she may be given a larger dose of epidural local anaesthetic.
The larger the dose used, the more likely it is that side effects will be evident. For example, very large doses of epidural anaesthetic can cause paralysis of the intercostal muscles and thoracic diaphragm (which are responsible for breathing), and loss of sympathetic nerve input to the heart, which may cause a significant decrease in heart rate and blood pressure. This may require emergency intervention, which may include support of the airway and the cardiovascular system.
The sensation of needing to urinate is often significantly diminished or even abolished after administration of epidural local anaesthetics and/or opioids. Because of this, a urinary catheter is often placed for the duration of the epidural infusion. People with continuous epidural infusions of local anaesthetic solutions typically ambulate only with assistance, if at all, in order to reduce the likelihood of injury due to a fall.
Large doses of epidurally administered opioids may cause troublesome itching, and respiratory depression.
failure to achieve analgesia or anaesthesia occurs in about 5% of cases, while another 15% experience only partial analgesia or anaesthesia. If analgesia is inadequate, another epidural may be attempted.
The following factors are associated with failure to achieve epidural analgesia/anaesthesia:
The use of air to find the epidural space while inserting the epidural instead of alternatives such as saline or lidocaine
Accidental dural puncture with headache (common, about 1 in 100 insertions). The epidural space in the adult lumbar spine is only 3-5mm deep, which means it is comparatively easy to cross it and accidentally puncture the dura (and arachnoid) with the needle. This may cause cerebrospinal fluid (CSF) to leak out into the epidural space, which may in turn cause a post dural puncture headache (PDPH). This can be severe and last several days, and in some rare cases weeks or months. It is caused by a reduction in CSF pressure and is characterised by postural exacerbation when the subject raises his/her head above the lying position. If severe it may be successfully treated with an epidural blood patch (a small amount of the subject's own blood given into the epidural space via another epidural needle which clots and seals the leak). Most cases resolve spontaneously with time. A change in headache pattern (e.g., headache worse when the subject lies down) should alert the physician to the possibility of development of rare but dangerous complications, such as subdural hematoma or cerebral venous thrombosis.
Delayed onset of breastfeeding and shorter duration of breastfeeding: In a study looking at breastfeeding 2 days after epidural anaesthesia, epidural analgesia in combination with oxytocin infusion caused women to have significantly lower oxytocin and prolactin levels in response to the baby breastfeeding on day 2 postpartum, which means less milk is produced. In many women undergoing epidural analgesia during labour oxytocin is used to augment uterine contractions.
Bloody tap (occurs in about 1 in 30-50).Template:Http://www.ncbi.nlm.nih.gov/m/pubmed/22726899 It is easy to injure an epidural vein with the needle. In people who have normal blood clotting, it is extremely rare (estimated less than 0.07%) for permanent neurological problems to develop.Template:Http://www.ncbi.nlm.nih.gov/m/pubmed/9009940/?i=14 However, people who have a coagulopathy may be at risk of epidural hematoma.
Catheter misplaced into a vein (uncommon, less than 1 in 300). Occasionally the catheter may be misplaced into an epidural vein, which results in all the anaesthetic being injected intravenously, where it can cause seizures or cardiac arrest in large doses (about 1 in 10,000 insertions). This also results in block failure.
High block, as described above (uncommon, less than 1 in 500).
Catheter misplaced into the subarachnoid space (rare, less than 1 in 1000). If the catheter is accidentally misplaced into the subarachnoid space (e.g. after an unrecognised accidental dural puncture), normally cerebrospinal fluid can be freely aspirated from the catheter (which would usually prompt the anaesthetist to withdraw the catheter and resite it elsewhere). If, however, this is not recognised, large doses of anaesthetic may be delivered directly into the cerebrospinal fluid. This may result in a high block, or, more rarely, a total spinal, where anaesthetic is delivered directly to the brainstem, causing unconsciousness and sometimes seizures.
Neurological injury lasting less than 1 year (rare, about 1 in 6,700).
Epidural abscess formation (very rare, about 1 in 145,000). Infection risk increases with the duration catheters are left in place, although infection was still uncommon after an average of 3 to 5 days' duration.
Death (extremely rare, less than 1 in 100,000).
The figures above relate to epidural anaesthesia and analgesia in healthy individuals.
Evidence to support the assertion that epidural analgesia increases the risk of anastomotic breakdown following bowel surgery is lacking.
"epidural anaesthesia and analgesia significantly slows the second stage of labour". The following are a few plausible hypotheses for this phenomenon:
The release of oxytocin, which stimulates the uterine contractions that are needed to move the child out through the vagina, may be decreased with epidural anaesthesia or analgesia due to factors involving the reduction of stress, such as:
Epidural analgesia may reduce the endocrine stress response to pain
Diminished release of epinephrine from the adrenal medulla slows the release of oxytocin
Diminished blood pressure, accommodated by both decreased stress and less adrenal release, may decrease the release of oxytocin as a natural mechanism to avoid hypotension. It may also affect the heart-rate of the fetus.
Still plausible (though less studied without a documented reproduction in a laboratory setting) are the effects of the reclined position of the woman on the fetus, both immediately prior to and during delivery.
These hypotheses generally posit an interaction with the force of gravity on fetal position and movement, as demonstrated by the following examples:
Transverse or posterior fetal positioning may become more likely as a result of the shift in orientation to gravitational force.
Diminished gravitational assistance is present in building pressure for commencing delivery and for progressing the fetus along the vagina.
It is important to note that the orientation of the fetus can be established by ultrasonic stenography prior to, during, and after the administration of an epidural block. This would seem a fine experiment for testing the first hypothesis. It should also be noted that the majority of fetal movement through the vagina is accomplished by cervical contractions, and so the role of gravity and its force relative to the position of the woman in labour (on delivery, not development) is difficult to establish.
There has been a good deal of concern, based on older observational studies, that women who have epidural analgesia during labour are more likely to require a cesarean delivery. However, the preponderance of evidence now supports the conclusion that the use of epidural analgesia during labour does not have a significant effect on rates of cesarean delivery. A Cochrane review of twenty trials involving a total of 6534 women estimated that women undergoing labour using epidural analgesia were only slightly more likely (1.07 times as likely) to undergo cesarean delivery than those in whom epidural analgesia was not used.
Epidural analgesia does increase the duration of the second stage of labour by 15 to 30 minutes and may increase the rate of instrument-assisted vaginal deliveries as well as that of oxytocin administration. Some people have also been concerned about whether the use of epidural analgesia in early labour increases the risk of cesarean delivery. Three randomized, controlled trials showed that early initiation of epidural analgesia (cervical dilatation, <4 cm) does not increase the rate of cesarean delivery among women with spontaneous or induced labour, as compared with early initiation of analgesia with parenteral opioids.
Fidel Pagés visiting injured soldiers at the Docker Hospital in Melilla in 1909.
In 1885, American neurologist James Leonard Corning (1855–1923), of Acorn Hall in Morristown, NJ, was the first to perform neuraxial blockade, when he injected 111 mg of cocaine into the epidural space of a healthy male volunteer (although at the time he believed he was injecting it into the subarachnoid space).
In 1921, Spanish military surgeon Fidel Pagés (1886–1923) developed the technique of "single-shot" lumbar epidural anaesthesia, which was later popularized by Italian surgeon Achille Mario Dogliotti (1897–1966).
In 1941, Robert Andrew Hingson (1913–1996) and Waldo B. Edwards developed the technique of continuous caudal anaesthesia using an indwelling needle. The first use of continuous caudal anaesthesia in a labouring woman was in 1942.
In 1947, Manuel Martínez Curbelo (1906–1962) was the first to describe placement of a lumbar epidural catheter.
^Norman D (2003). "Epidural analgesia using loss of resistance with air versus saline: does it make a difference? Should we reevaluate our practice?". AANA J71 (6): 449–53. PMID15098532.
^Beilin Y, Arnold I, Telfeyan C, Bernstein HH, Hossain S (2000). "Quality of analgesia when air versus saline is used for identification of the epidural space in the parturient". Reg Anesth Pain Med25 (6): 596–9. doi:10.1053/rapm.2000.9535. PMID11097666.
^Bubeck J, Boos K, Krause H, Thies KC (2004). "Subcutaneous tunneling of caudal catheters reduces the rate of bacterial colonization to that of lumbar epidural catheters". Anesth Analg99 (3): 689–93, table of contents. doi:10.1213/01.ANE.0000130023.48259.FB. PMID15333395.
^Patel SS, Dunn CJ, Bryson HM (1996). "Epidural clonidine: a review of its pharmacology and efficacy in the management of pain during labour and postoperative and intractable pain". CNS Drugs6 (6): 474–497. doi:10.2165/00023210-199606060-00007.
^ abAnim-Somuah, M.; Smyth, R. M.; Jones, L. (2011). "Epidural versus non-epidural or no analgesia in labour". In Anim-Somuah, Millicent. Cochrane Database of Systematic Reviews (12). pp. CD000331. doi:10.1002/14651858.CD000331.pub3. PMID22161362.edit
^Salem, I. C.; Fukushima, F. B.; Nakamura, G.; Ferrari, F.; Navarro, L. C.; Castiglia, Y. M.; Ganem, E. M. (2007). "Side effects of subarachnoid and epidural sufentanil associated with a local anesthetic in patients undergoing labor analgesia". Revista brasileira de anestesiologia57 (2): 125–135. PMID19466346. edit
^"Anesthesia". Harvard University Press. Retrieved 18 April 2014.
^Yokoyama M, Itano Y, Katayama H et al. (2005). "The effects of continuous epidural anesthesia and analgesia on stress response and immune function in patients undergoing radical esophagectomy". Anesth Analg101 (5): 1521–7. doi:10.1213/01.ANE.0000184287.15086.1E. PMID16244024.
^ abGendall KA, Kennedy RR, Watson AJ, Frizelle FA (2007). "The effect of epidural analgesia on postoperative outcome after colorectal surgery". Colorectal Dis9 (7): 584–98; discussion 598–600. doi:10.1111/j.1463-1318.2007.1274.x. PMID17506795.
^Haberkern CM, Lynn AM, Geiduschek JM et al. (1996). "Epidural and intravenous bolus morphine for postoperative analgesia in infants". Can J Anaesth43 (12): 1203–10. doi:10.1007/BF03013425. PMID8955967.
^Agaram R, Douglas MJ, McTaggart RA, Gunka V. Inadequate pain relief with labour epidurals: a multivariate analysis of associated factors. Int J Obstet Anesth. 2009.18(1):10-4.
^Sprigge JS, Harper SJ (2008). "Accidental dural puncture and post dural puncture headache in obstetric anaesthesia: presentation and management: a 23-year survey in a district general hospital". Anaesthesia63 (1): 36–43. doi:10.1111/j.1365-2044.2007.05285.x. PMID18086069.
^ abWilson IH, Allman KG (2006). Oxford handbook of anaesthesia. Oxford: Oxford University Press. p. 20. ISBN0-19-856609-3.
^Jonas W; Johansson LM; Nissen E et al. (2009). "Effects of Intrapartum Oxytocin Administration and Epidural Analgesia on the Concentration of Plasma Oxytocin and Prolactin, in Response to Suckling During the Second Day Postpartum". Breastfeed Med4 (2): 71–82. doi:10.1089/bfm.2008.0002. PMID19210132.
^Clarkson CW, Hondeghem LM (1985). "Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the action potential with slow recovery from block during diastole". Anesthesiology62 (4): 396–405. doi:10.1097/00000542-198504000-00006. PMID2580463.
^Scott, DA; Beilby, DS; McClymont, C (1995). "Postoperative analgesia using epidural infusions of fentanyl with bupivacaine. A prospective analysis of 1,014 patients". Anesthesiology83 (4): 727–37. doi:10.1097/00000542-199510000-00012. PMID7574052.
^ abWilson IH, Allman KG (2006). Oxford handbook of anaesthesia. Oxford: Oxford University Press. p. 21. ISBN0-19-856609-3.
^Liu EHC, Sia ATH (2004). "Rates of caesarean section and instrumental vaginal delivery in nulliparous women after low concentration epidural infusions or opioid analgesia: systematic review". BMJ328 (7453): 1410–1415. doi:10.1136/bmj.38097.590810.7C.
^Halpern SH, Muir H, Breen TW et al. (2004). "A multicenter randomized controlled trial comparing patient-controlled epidural with intravenous analgesia for pain relief in labor". Anesth Analg99 (5): 1532–1538. doi:10.1213/01.ANE.0000136850.08972.07. PMID15502060.
^Wong CA, Scavone BM, Peaceman AM et al. (2005). "The risk of cesarean delivery with neuraxial analgesia given early versus late in labor". N Engl J Med352 (7): 655–665. doi:10.1056/NEJMoa042573. PMID15716559.
^Ohel G, Gonen R, Vaida S, Barak S, Gaitini L (2006). "Early versus late initiation of epidural analgesia in labor: does it increase the risk of cesarean section? A randomized trial". Am J Obstet Gynecol194 (3): 600–605. doi:10.1016/j.ajog.2005.10.821. PMID16522386.
^Wong CA, McCarthy RJ, Sullivan JT, Scavone BM, Gerber SE, Yaghmour EA. Early compared with late neuraxial analgesia in nulliparous labor induction: a randomized controlled trial.
^Corning, JL (1885). "Spinal anaesthesia and local medication of the cord". New York Medical Journal42: 483–5.
^Marx, GF (1994). "The first spinal anesthesia. Who deserves the laurels?". Regional Anesthesia19 (6): 429–30. PMID7848956.
^Pagés, F (1921). "Anestesia metamérica". Revista de Sanidad Militar (in Spanish) 11: 351–4.
^Martinez Curbelo, M (1949). "Continuous peridural segmental anesthesia by means of a ureteral catheter". Curr Res Anesth Analg28 (1): 13–23. PMID18105827.
Boqing Chen and Patrick M. Foye, UMDNJ: New Jersey Medical School, Epidural Steroid Injections: Non-surgical Treatment of Spine Pain, eMedicine: Physical Medicine and Rehabilitation (PM&R), August 2005. Also available online.