Dimples may appear and disappear over an extended period. They may be genetically inherited and have been called a simple dominant trait.
Dimples are a facial muscle deformity. Dimples may be caused by variations in the structure of the facial muscle known as zygomaticus major. Specifically, the presence of a double or bifid zygomaticus major muscle may explain the formation of cheek dimples. This bifid variation of the muscle originates as a single structure from the zygomatic bone. As it travels anteriorly, it then divides with a superior bundle that inserts in the typical position above the corner of the mouth. An inferior bundle inserts below the corner of the mouth.