Dicycloverine

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Dicycloverine
Systematic (IUPAC) name
2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate
Clinical data
Trade namesByclomine, Bentyl, Dibent, Di-Spaz, Dilomine
AHFS/Drugs.comInternational Drug Names
MedlinePlusa684007
Pregnancy cat.B (US)
Legal status ?
Pharmacokinetic data
Protein binding>99%
Half-life5 h
Identifiers
CAS number77-19-0 YesY
ATC codeA03AA07
PubChemCID 3042
IUPHAR ligand355
DrugBankDB00804
ChemSpider2934 YesY
UNII4KV4X8IF6V YesY
KEGGD07820 YesY
ChEBICHEBI:4514 YesY
ChEMBLCHEMBL1123 YesY
Chemical data
FormulaC19H35NO2 
Mol. mass309.487 g/mol
 YesY (what is this?)  (verify)
 
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Dicycloverine
Systematic (IUPAC) name
2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate
Clinical data
Trade namesByclomine, Bentyl, Dibent, Di-Spaz, Dilomine
AHFS/Drugs.comInternational Drug Names
MedlinePlusa684007
Pregnancy cat.B (US)
Legal status ?
Pharmacokinetic data
Protein binding>99%
Half-life5 h
Identifiers
CAS number77-19-0 YesY
ATC codeA03AA07
PubChemCID 3042
IUPHAR ligand355
DrugBankDB00804
ChemSpider2934 YesY
UNII4KV4X8IF6V YesY
KEGGD07820 YesY
ChEBICHEBI:4514 YesY
ChEMBLCHEMBL1123 YesY
Chemical data
FormulaC19H35NO2 
Mol. mass309.487 g/mol
 YesY (what is this?)  (verify)

Dicycloverine, also known as dicyclomine, is an anticholinergic that blocks muscarinic receptors. Dicycloverine was first synthesized in the United States circa 1947.

Medical uses[edit]

10mg oral capsule of Dicyclomine Hydrochloride, manufactured by Mylan.

Dicyclomine is used to treat intestinal hypermotility and the symptoms of irritable bowel syndrome (IBS) (also known as spastic colon). It relieves muscle spasms and cramping in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells. It is a smooth muscle relaxant.[1]

In the UK, it is an ingredient of a multi-ingredient preparation, together with an antiflatulent (simethicone) and two antacids, under the trade name Kolanticon.

In France, it is an ingredient of a multi-ingredient preparation, together with colchicine, under the brand Colchimax.

It is also marketed as Meftal-SPAS containing mefenamic acid along with dicyclomine hydrochloride as an analgesic and antispasmodic.

Side effects[edit]

Dicyclomine can cause a range of anticholinergic side effects such as dry mouth, nausea, and, at higher doses, deliriant effects.[1] Recreational use of this drug for its anticholinergic effects has been rarely reported.[1][2]

Caution[edit]

Breastfeeding is not recommended while using this drug. Users should use care when operating vehicles and/or dangerous machines.[1]

Notes[edit]

  1. ^ a b c d "Dicyclomine hydrochloride". Monograph. Drugs.com. 
  2. ^ Carlini E. A. (1993). "Preliminary note: dangerous use of anticholinergic drugs in Brazil". Drug and Alcohol Dependence 32 (1): 1–7. doi:10.1016/0376-8716(93)90016-J. PMID 8486081. 

References[edit]

External links[edit]