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Established in 1999 by former AM:PM and Cooltempo A&R man Simon Dunmore and initially co-owned by London nightclub and label Ministry of Sound, Defected's first release was Soulsearcher's "I Can't Get Enough", which reached No. 5 in the UK singles chart. This early success was followed up with Roger Sanchez's "Another Chance", which hit No. 1 in the UK singles chart in 2001. To date, Defected has released more than 300 singles from artists such as Bob Sinclar, Kings of Tomorrow, Dennis Ferrer, Martin Solveig, Copyright and ATFC}
In addition to the 2001 No.1 one from Sanchez, Defected has released a number of records that have had a significant impact on the house scene. Kings of Tomorrow's "Finally" was voted the 31st best track of 2000–2010 by leading electronic dance music portal Resident Advisor, and is still a regular feature of DJ sets to this day. Bob Sinclar's 2005 track "Love Generation" reached No.12 in the UK singles chart and was a massive hit all over Europe and in Australia, achieving one of the longest runs of all time in the German singles charts and going on to sell over 1 million copies worldwide.The Irish Duo Fish go deep also had success with there hit "Cure and the Cause" which stayed in the Beatport top 100 for almost a year. which More recently, Defected have found success with underground hits like Dennis Ferrer's "Hey Hey".
Defected has not had a significant chart release for a number of years.
Defected's acclaimed In The House series launched in 2003 with Jay-J & Miguel Migs and has since featured artists such as Gilles Peterson, The Shapeshifters, Louie Vega and Tensnake, as well as annual compilations dedicated to Ibiza and Miami and other notable clubbing destinations.
Defected In The House events bring some of the world's biggest DJs to clubbers around the globe, with regular events at London's Ministry of Sound, Singapore's Zouk and Jakarta's Dragon Fly. Defected In The House also has a Saturday residency at Pacha in Ibiza throughout the summer season (June – September).