De novo may also be a term used to define methods for making predictions about biological features using only a computational model without extrinsic comparison to existing data. In this context, it may be sometimes interchangeable with the Latin term ab initio.
De novo hybrid, an organism newly derived from two distinct parent taxa (i.e., an F1 hybrid or hybrid not far removed from the F1 generation).
De novo search, signifying the start of a new (or repeated from the start) algorithm in computer science, discrete and computational geometry, and in particular, a packing problem.
De novo bank, a state bank that has been in operation for five years or less
In financial terminology, numbers reported by newly founded companies (especially the financial services industry) are qualified as de novo, to distinguish them from older companies. For example, "growth de novo" means growth of newly started companies.
In the context of marketing and advertising, de novo means "again, but in a different way" and is linked to guerrilla and grass roots marketing campaigns.