Perlmutter is best known for authoring the #1 New York Times bestselling book Grain Brain, released September, 2013 in which he addresses nutritional and lifestyle influences and their impact on neurological disorders.
Perlmutter has received awards for his approaches to neurological disorders including the 2002 Linus Pauling Award, 2006 National Nutritional Foods Association (the "leading representative of the dietary supplement industry" ) Clinician of the Year Award, and 2010 Humanitarian of the Year award from the American College of Nutrition.
Perlmutter's book has received criticism for perceived 'hyperbole' and misrepresentation of data.
Epidemiologist Dr. David Katz, founding director of Yale University's Prevention Research Center, has criticized Grain Brain, saying "Perlmutter is way ahead of any justifiable conclusion" and that many of its claims are "wildly preposterous". 
with Loberg, Kristin (September 17, 2013). Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers. Little, Brown and Company. ISBN031623480X.
with Villoldo, Alberto (February 1, 2012). Power Up Your Brain: The Neuroscience of Enlightenment. Hay House. ISBN1401928188.
with Colman, Carol (August 2, 2005) . The Better Brain Book: The Best Tool for Improving Memory and Sharpness and Preventing Aging of the Brain. Riverhead Trade. ISBN1594480931.
with Colman, Carol (March 11, 2008) . Raise a Smarter Child by Kindergarten: Raise IQ by up to 30 points and turn on your child's smart genes. Harmony. ISBN0767923022.