DNA codon table

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The genetic code is traditionally represented as a RNA codon table due to the biochemical nature of the protein translation process. However, with the rise of computational biology and genomics, proteins have become increasingly studied at a genomic level. As a result, the practice of representing the genetic code as a DNA codon table has become more popular. The DNA codons in such tables occur on the sense DNA strand and are arranged in a 5' → 3' direction.

nonpolarpolarbasicacidic(stop codon)
Standard genetic code
1st
base
2nd base3rd
base
TCAG
TTTT(Phe/F) PhenylalanineTCT(Ser/S) SerineTAT(Tyr/Y) TyrosineTGT(Cys/C) CysteineT
TTCTCCTACTGCC
TTA(Leu/L) LeucineTCATAAStop (Ochre)TGAStop (Opal)A
TTGTCGTAGStop (Amber)TGG(Trp/W) Tryptophan    G
CCTTCCT(Pro/P) ProlineCAT(His/H) HistidineCGT(Arg/R) ArginineT
CTCCCCCACCGCC
CTACCACAA(Gln/Q) GlutamineCGAA
CTGCCGCAGCGGG
AATT(Ile/I) IsoleucineACT(Thr/T) Threonine        AAT(Asn/N) AsparagineAGT(Ser/S) SerineT
ATCACCAACAGCC
ATAACAAAA(Lys/K) LysineAGA(Arg/R) ArginineA
ATG[A](Met/M) MethionineACGAAGAGGG
GGTT(Val/V) ValineGCT(Ala/A) AlanineGAT(Asp/D) Aspartic acidGGT(Gly/G) GlycineT
GTCGCCGACGGCC
GTAGCAGAA(Glu/E) Glutamic acidGGAA
GTGGCGGAGGGGG
A The codon ATG both codes for methionine and serves as an initiation site: the first ATG in an mRNA's coding region is where translation into protein begins.[1]
Inverse table (compressed using IUPAC notation)
Amino acidCodonsCompressedAmino acidCodonsCompressed
Ala/AGCT, GCC, GCA, GCGGCNLeu/LTTA, TTG, CTT, CTC, CTA, CTGYTR, CTN
Arg/RCGT, CGC, CGA, CGG, AGA, AGGCGN, MGRLys/KAAA, AAGAAR
Asn/NAAT, AACAAYMet/MATG
Asp/DGAT, GACGAYPhe/FTTT, TTCTTY
Cys/CTGT, TGCTGYPro/PCCT, CCC, CCA, CCGCCN
Gln/QCAA, CAGCARSer/STCT, TCC, TCA, TCG, AGT, AGCTCN, AGY
Glu/EGAA, GAGGARThr/TACT, ACC, ACA, ACGACN
Gly/GGGT, GGC, GGA, GGGGGNTrp/WTGG
His/HCAT, CACCAYTyr/YTAT, TACTAY
Ile/IATT, ATC, ATAATHVal/VGTT, GTC, GTA, GTGGTN
STARTATGSTOPTAA, TGA, TAGTAR, TRA

See also[edit]

References[edit]

  1. ^ Nakamoto T (March 2009). "Evolution and the universality of the mechanism of initiation of protein synthesis". Gene 432 (1–2): 1–6. doi:10.1016/j.gene.2008.11.001. PMID 19056476.