DEDD

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Death effector domain containing
Identifiers
SymbolsDEDD; CASP8IP1; DEDD1; DEFT; FLDED1
External IDsOMIM606841 MGI1333874 HomoloGene7980 GeneCards: DEDD Gene
RNA expression pattern
PBB GE DEDD 215158 s at tn.png
PBB GE DEDD 202480 s at tn.png
PBB GE DEDD 211255 x at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez919121945
EnsemblENSG00000158796ENSMUSG00000013973
UniProtO75618Q9Z1L3
RefSeq (mRNA)NM_001039711.1NM_001128609.1
RefSeq (protein)NP_001034800.1NP_001122081.1
Location (UCSC)Chr 1:
161.09 – 161.1 Mb
Chr 1:
171.33 – 171.34 Mb
PubMed search[1][2]
 
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Death effector domain containing
Identifiers
SymbolsDEDD; CASP8IP1; DEDD1; DEFT; FLDED1
External IDsOMIM606841 MGI1333874 HomoloGene7980 GeneCards: DEDD Gene
RNA expression pattern
PBB GE DEDD 215158 s at tn.png
PBB GE DEDD 202480 s at tn.png
PBB GE DEDD 211255 x at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez919121945
EnsemblENSG00000158796ENSMUSG00000013973
UniProtO75618Q9Z1L3
RefSeq (mRNA)NM_001039711.1NM_001128609.1
RefSeq (protein)NP_001034800.1NP_001122081.1
Location (UCSC)Chr 1:
161.09 – 161.1 Mb
Chr 1:
171.33 – 171.34 Mb
PubMed search[1][2]

Death effector domain-containing protein is a protein that in humans is encoded by the DEDD gene.[1][2][3]

This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.[3]

Interactions

DEDD has been shown to interact with Caspase 8,[1][4][5] FADD[1][6] and CFLAR.[4][6]

References

  1. ^ a b c Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhansel C, Hofmann TG, Grummt I, Krammer PH, Peter ME (Dec 1998). "DEDD, a novel death effector domain-containing protein, targeted to the nucleolus". EMBO J 17 (20): 5974–86. doi:10.1093/emboj/17.20.5974. PMC 1170924. PMID 9774341. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1170924/. 
  2. ^ Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ (Dec 1998). "DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells". Endocrinology 139 (12): 4839–48. doi:10.1210/en.139.12.4839. PMID 9832420. 
  3. ^ a b "Entrez Gene: DEDD death effector domain containing". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9191. 
  4. ^ a b Zhan, Y; Hegde R, Srinivasula S M, Fernandes-Alnemri T, Alnemri E S (Apr. 2002). "Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC". Cell Death Differ. (England) 9 (4): 439–47. doi:10.1038/sj/cdd/4401038. ISSN 1350-9047. PMID 11965497. 
  5. ^ Alcivar, Allison; Hu Shimin, Tang Jun, Yang Xiaolu (Jan. 2003). "DEDD and DEDD2 associate with caspase-8/10 and signal cell death". Oncogene (England) 22 (2): 291–7. doi:10.1038/sj.onc.1206099. ISSN 0950-9232. PMID 12527898. 
  6. ^ a b Roth, Wilfried; Stenner-Liewen Frank, Pawlowski Krzysztof, Godzik Adam, Reed John C (Mar. 2002). "Identification and characterization of DEDD2, a death effector domain-containing protein". J. Biol. Chem. (United States) 277 (9): 7501–8. doi:10.1074/jbc.M110749200. ISSN 0021-9258. PMID 11741985. 

Further reading