Liothyronine

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Liothyronine sodium
Systematic (IUPAC) name
sodium (2S)-2-amino-3- [4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl] propanoate
Clinical data
Trade namesCytomel
AHFS/Drugs.commonograph
MedlinePlusa682462
Pregnancy cat. ?
Legal status ?
Pharmacokinetic data
Protein binding99.7%
Half-life2.5 days
Identifiers
CAS number6893-02-3 YesY
ATC codeH03AA02
PubChemCID 16218759
IUPHAR ligand2634
DrugBankDB00279
ChemSpider17346129 YesY
UNII06LU7C9H1V YesY
ChEBICHEBI:6484 N
ChEMBLCHEMBL1201119 N
Chemical data
FormulaC15H11I3NNaO4 
Mol. mass672.96 g/mol
 N (what is this?)  (verify)
 
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Liothyronine sodium
Systematic (IUPAC) name
sodium (2S)-2-amino-3- [4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl] propanoate
Clinical data
Trade namesCytomel
AHFS/Drugs.commonograph
MedlinePlusa682462
Pregnancy cat. ?
Legal status ?
Pharmacokinetic data
Protein binding99.7%
Half-life2.5 days
Identifiers
CAS number6893-02-3 YesY
ATC codeH03AA02
PubChemCID 16218759
IUPHAR ligand2634
DrugBankDB00279
ChemSpider17346129 YesY
UNII06LU7C9H1V YesY
ChEBICHEBI:6484 N
ChEMBLCHEMBL1201119 N
Chemical data
FormulaC15H11I3NNaO4 
Mol. mass672.96 g/mol
 N (what is this?)  (verify)

Liothyronine is a form of thyroid hormone used to treat hypothyroidism and myxedema coma. It is marketed as the sodium salt under the brand name Cytomel (or Tertroxin in Australia).

Contents

Pharmacology

Liothyronine is the most potent form of thyroid hormone. As such, it acts on the body to increase the basal metabolic rate, effect protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness. The thyroid hormones are essential to proper development and differentiation of all cells of the human body. These hormones also regulate protein, fat, and carbohydrate metabolism, affecting how human cells use energetic compounds.

In comparison to levothyroxine (T4), liothyronine has a faster onset of action as well as a shorter biological half-life, which may be due to less plasma protein binding to thyroxine-binding globulin and transthyretin.

Side effects

Liothyronine may cause a number of side effects, mostly similar to symptoms of hyperthyroidism, which include:[1]

Black box warning

The package insert for Cytomel contains the following black box warning:[2]

Drugs with thyroid hormone activity, alone or together with other therapeutic agents, have been used for the treatment of obesity. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.

Uses

Physicians can use this instead of levothyroxine (T4) for patients undergoing thyroid withdrawal. When a patient has thyroid cancer or Graves' disease, ablation therapy with radioactive iodine (I131) can be used to remove any trace thyroid tissue. For I131 therapy to be effective, the trace thyroid tissue must be avid to iodine. The best method is to starve the tissue of iodine but this can lead to hypothyroid symptoms for the patient. Withdrawal from levothyroxine can be done but it takes six weeks of withdrawal for the remaining thyroid tissue to be completely starved. Six weeks is needed owing to levothyroxine's long half life. Six weeks can be inconvenient for the patient and delay treatment. Liothyronine instead can be taken and withdrawn from for two weeks to starve the thyroid tissue. This is much safer and more convenient than levothyroxine.

See also

References

  1. ^ MedlinePlus. "Liothyronine." Last accessed July 14, 2007.
  2. ^ United States Food & Drug Administration. "Cytomel." Last accessed July 14, 2007.

External links