He graduated from Penn State with a Bachelor of Arts degree in integrative arts in 2000.
At the Penn State pro day Brown measured 6'4⅞" 271-pounds, ran a 4.52 seconds forty-yard dash, had a vertical leap of 37" and bench-pressed 225 pounds 26 times.
Brown was drafted by the Browns first overall in the 2000 NFL Draft, making him the eleventh defensive lineman to be taken first overall in the 70-plus year history of the NFL Draft.
Brown had a productive rookie season, recording 70 total tackles and 4.5 sacks. His second season was cut short due to injury, but Brown recorded 4.5 sacks in 5 games. Brown had problems staying healthy for the rest of his career, and struggled on the field. From 2002-2004, Brown only played in 26 games and recorded just 8 sacks. He finished his professional football career with the Broncos in 2005.