Conversion disorder

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Conversion disorder
Classification and external resources
ICD-10F44
ICD-9300.11
DiseasesDB1645
MedlinePlus000954
eMedicineemerg/112 med/1150
MeSHD003291
 
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Conversion disorder
Classification and external resources
ICD-10F44
ICD-9300.11
DiseasesDB1645
MedlinePlus000954
eMedicineemerg/112 med/1150
MeSHD003291

A conversion disorder causes patients to suffer from neurological symptoms, such as numbness, blindness, paralysis, or fits without a definable organic cause. It is thought that symptoms arise in response to stressful situations affecting a patient's mental health. Conversion disorder is considered a psychiatric disorder in the Diagnostic and Statistical Manual of Mental Disorders fifth edition (DSM-5).[1]

Formerly known as "hysteria", the disorder has arguably been known for millennia, though it came to greatest prominence at the end of the 19th century, when the neurologist Jean-Martin Charcot, physician and personality theorist Sigmund Freud and psychiatrist Pierre Janet focused their studies on the subject. Before Freud's studies on hysteria, people who suffered from physical disabilities that were not caused by any physical impairments, known as hysterical patients, were believed to be malingering, suffering from weak nerves, or just suffering from meaningless disturbances. The term "conversion" has its origins in Freud's doctrine that anxiety is "converted" into physical symptoms.[2] Though previously thought to have vanished from the west in the 20th century, some research has suggested it is as common as ever.[3]

The DSM-IV classifies conversion disorder as a somatoform disorder while the ICD-10 classifies it as a dissociative disorder.

Definition[edit]

DSM-IV defines conversion disorder as follows:

The nature of the association between the psychological factors and the neurological symptoms remains unclear. Earlier versions of the DSM-IV employed psychodynamic concepts, but these have been incrementally removed from successive versions.

The tenth revision of the World Health Organization's International Classification of Diseases uses the term "conversion" as an alternative descriptor for the dissociative disorders class of mental and behavioural disorders (i.e. the F44 class), with the explicit suggestion that dissociative and conversion symptoms probably share common psychological mechanisms.[4] In ICD-10, the dissociative [conversion] disorders class includes 10 disorders that, in addition to specific criteria for each individual disorder, must each meet the following general criteria:

Signs and symptoms[edit]

Typically conversion syndrome begins with some stressor, trauma, or psychological distress that manifests itself as physical symptoms. Usually the physical symptoms of the syndrome affect the senses and movement. For example, someone experiencing conversion syndrome may become temporarily blind due to the stress of the loss of a parent or spouse. While there can be a wide range in severity and duration, symptoms are typically short-lived and relatively mild.[5]

Some of the most typical symptoms include blindness, partial or total paralysis, inability to speak, deafness, numbness, sores, difficulty swallowing, incontinence, balance problems, seizures, tremors, and difficulty walking. These symptoms are attributed to conversion syndrome when a medical explanation for the afflictions cannot be found.[6] Symptoms of conversion syndrome usually occur suddenly, however symptoms are usually relatively brief, with the average duration being 2 weeks up to years in people hospitalized for conversion syndrome-related presentations. While symptoms do not usually last a long time, recurrence is frequently seen. In fact, about 20% to 25% of conversion syndrome sufferers reported a symptomatic episode within a year. Conversion disorder is typically seen in individuals 10 to 35 years old.[7]

Conversion disorder can present with motor or sensory symptoms including any of the following:

Motor symptoms or deficits:

Sensory symptoms or deficits:

Conversion symptoms typically do not conform to known anatomical pathways and physiological mechanisms, but instead follow the individual's conceptualization of a condition. Typically, the less medical knowledge a person has, the more implausible are the presenting symptoms. Persons with more sophisticated medical knowledge tend to have more subtle symptoms and deficits that may closely simulate neurological or other general medical conditions.[7]

Mass psychogenic illness[edit]

The DSM-IV-TR does not have specific diagnosis for mass psychogenic illness but the text describing conversion disorder states that "In 'epidemic hysteria,' shared symptoms develop in a circumscribed group of people following 'exposure' to a common precipitant."

Causes[edit]

The original Freudian model[2] suggested that the emotional charge of painful experiences would be consciously repressed as a way of managing the pain, but this emotional charge would be somehow "converted" into the neurological symptoms. Freud later argued that the repressed experiences were of a sexual nature.[8] As Peter Halligan comments, conversion has 'the doubtful distinction among psychiatric diagnoses of still invoking Freudian mechanisms'.[9]

Janet, the other great theoretician of hysteria, argued that symptoms arose through the power of suggestion, acting on a personality vulnerable to dissociation.[10] In this hypothetical process, the subject's experience of their leg, for example, is split-off from the rest of their consciousness, resulting in paralysis or numbness in that leg. Later authors have attempted to combine elements of these models, but none of them has a firm empirical basis.[11]

Some support for the Freudian model comes from findings of high rates of childhood sexual abuse in conversion patients[12] and from a recent neuroimaging study showing abnormal emotion processing of a traumatic event linked to motor processing of the affected limb, in a patient with conversion.[13] Support for the dissociation model comes from studies showing heightened suggestibility in conversion patients,[14] and in abnormalities in motor imagery.[15]

Much recent work has been done to identify the underlying causes of the somatoform disorders as well as to better understand why conversion and hysteria appear more commonly in women. Current theoreticians tend to believe that there is no single reason that people tend to somatize, or use their bodies to express emotional issues. Instead, the emphasis tends to be on the individual understanding of the patient as well as on a variety of therapeutic techniques. While the exact causes of conversion syndrome are unknown, symptoms of the disorder seem to relate to the occurrence of a psychological conflict or stressor. Usually the onset of the disorder correlates to a traumatic or stressful event, There are also certain populations that are considered at risk for conversion disorder including people suffering from a medical illness or condition, people with personality disorder, and individuals with dissociative identity disorder.[6]

There has been much recent interest in functional neuroimaging in conversion. As researchers identify the mechanisms which underlie conversion symptoms it is hoped these will allow the development of a neuropsychological model. A number of such studies have been performed, including some which suggest that blood flow in patients' brains may be abnormal while they are unwell. These have all been too small to be confident of the generalisability of their findings, however, so no neuropsychological model has been clearly established.

A 2007 review stated that conversion disorder and dissociative disorders are statistically associated, share features such as a history of abuse and high suggestibility, and likely have common underlying causes. It recommended that DSM should follow ICD-10 and reclassify conversion disorder from a somatoform disorder to a dissociative disorder.[16]

An evolutionary psychology explanation for conversion disorder is that the symptom may have been evolutionarily advantageous during warfare. A non-combatant with these symptoms signals non-verbally, possibly to someone speaking a different language, that she or he is not dangerous as a combatant and also may be carrying some form of dangerous infectious disease. This can explain that conversion disorder may develop following a threatening situation, that there may be a group effect with many people simultaneously developing similar symptoms (as in mass psychogenic illness), and the gender difference in prevalence.[17]

Diagnosis[edit]

The diagnosis of conversion disorder involves three elements: the exclusion of neurological disease, the exclusion of feigning, and the determination of a psychological mechanism. Each of these has difficulties.

Exclusion of neurological disease[edit]

Conversion disorder presents with symptoms that typically resemble a neurological disorder such as stroke, multiple sclerosis, epilepsy or hypokalemic periodic paralysis. The neurologist must carefully exclude neurological disease, through examination and appropriate investigations.[18] However, it is not uncommon for patients with neurological disease to also have conversion disorder.[19]

In excluding neurological disease, the neurologist has traditionally relied partly on the presence of positive signs of conversion disorder — certain aspects of the presentation that were thought to be rare in neurological disease, but common in conversion. The validity of many of these signs has been questioned, however, by a study showing that they also occurred in neurological disease.[20] One such symptom, for example, is La belle indifférence, described in DSM-IV as "a relative lack of concern about the nature or implications of the symptoms". In a later study no evidence was found that patients with "functional" symptoms are any more likely to exhibit this than patients with a confirmed organic disease.[21]

Another feature thought to be important was that symptoms would tend to be more severe on the non-dominant (usually left) side; there were a variety of theories such as the relative involvement of cerebral hemispheres in emotional processing, or more simply just that it was "easier" to live with a functional deficit on the non-dominant side. However, a literature review of 121 studies established that this was not true, with publication bias the most likely explanation for this commonly held view.[22] Although agitation is often assumed to be a positive sign of conversion disorder, release of epinephrine is a well-demonstrated cause of paralysis from hypokalemic periodic paralysis.[23]

The process of exclusion is not perfect, so misdiagnoses will occur. In a highly influential[24] study from the 1960s, Eliot Slater demonstrated that misdiagnoses had occurred in one third of his 112 patients with conversion disorder.[25] Later authors have argued that the paper was flawed, however,[26][27] and a meta-analysis has shown that misdiagnosis rates since that paper are around 4%, the same as for other neurological diseases.[28]

Exclusion of feigning[edit]

Conversion disorder is unique in DSM-IV in explicitly requiring the exclusion of deliberate feigning. Unfortunately, this is only likely to be demonstrable where the patient confesses, or is "caught out" in a broader deception, such as a false identity.[29] One neuroimaging study suggested that feigning may be distinguished from conversion by the pattern of frontal lobe activation;[30] however this is a research, rather than a clinical technique. True rates of feigning in medicine remain unknown, though neurological presentations of feigning may be among the more common.[31]

Establishing a psychological mechanism[edit]

The psychological mechanism can be the most difficult aspect of the conversion diagnosis. DSM-IV requires that the clinician believe preceding stressors or conflicts to be associated with the development of the disorder, though how this might come about is still the subject of debate.

Treatment[edit]

There are a number of different treatments that are available to treat and manage conversion syndrome. While occasionally symptoms do disappear on their own, many people benefit from a variety of treatment options. Treatments for conversion syndrome include hypnosis, psychotherapy, physical therapy, stress management, and transcranial magnetic stimulation. Treatment plans will consider duration and presentation of symptoms and may include one or multiple of the above treatments.[5] This may include the following:[32]

  1. Explanation. This must be clear and coherent as attributing physical symptoms to a psychological cause is not accepted by many educated people in western cultures. It must emphasize the genuineness of the condition, that it is common, potentially reversible and does not mean that the sufferer is psychotic. Taking an etiologically neutral stance by describing the symptoms as functional may be helpful but further studies are required. Ideally, the patient should be followed up neurologically for a while to ensure that the diagnosis has been understood.
  2. Physiotherapy where appropriate;
  3. Occupational Therapy to maintain autonomy in activities of daily living;[33]
  4. Treatment of comorbid depression or anxiety if present.

There is little evidence-based treatment of conversion disorder.[34][full citation needed] Other treatments such as cognitive behavioral therapy, hypnosis, EMDR, and psychodynamic psychotherapy, EEG brain biofeedback need further trials.

Prognosis[edit]

The DSM-IV-TR states that conversion symptoms will in most cases disappear within 2 weeks in those hospitalized. One-fifth to one-quarter will have a recurrence within a year with this also predicting future recurrences. Acute onset, clearly identifiable stress at this time, and short time between onset and treatment are associated with a favorable prognosis.

Epidemiology[edit]

Frequency[edit]

Information on the frequency of conversion disorder in the West is limited, in part due to the complexities of the diagnostic process. In neurology clinics, the reported prevalence of unexplained symptoms among new patients is very high (between 30 and 60%)[35][36][37] However, diagnosis of conversion typically requires an additional psychiatric evaluation, and since few patients will see a psychiatrist[38] it is unclear what proportion of the unexplained symptoms are actually due to conversion. Large scale psychiatric registers in the US and Iceland found incidence rates of 22 and 11 newly diagnosed cases per 100,000 person-years, respectively,[39]

Culture[edit]

Although it is often thought that the frequency of conversion may be higher outside of the West, perhaps in relation to cultural and medical attitudes, evidence of this is limited.[3] A community survey of urban Turkey found a prevalence of 5.6%.[40] Many authors have found occurrence of conversion to be more frequent in rural, lower socio-economic groups, where technological investigation of patients is limited and individuals may be less knowledgeable about medical and psychological concepts.[39][41][42]

Gender[edit]

Historically, the concept of 'hysteria' was originally understood to be a condition exclusively affecting women, though the concept was eventually extended to men. In recent surveys of conversion disorder (formerly classified as "hysterical neurosis, conversion type"),[35][40] females predominate, with between 2 and 6 female patients for every male.

Age[edit]

Conversion disorder may present at any age but is rare in children younger than 10 years or in the elderly. Studies suggest a peak onset in the mid-to-late 30s.[35][39][40]

History[edit]

Conversion disorder has been described as early as the time of Hippocrates.[43]

In the 19th century, physicians such as Silas Weir Mitchell in the US and Paul Briquet (fr) and Jean-Martin Charcot in France developed ideas about patients sharing unexplained neurological symptoms. Charcot specialised in treating patients who were suffering from a variety of unexplained physical symptoms including paralysis, contractures (muscles which contract and cannot be relaxed) and seizures. Some of these patients sporadically and compulsively adopted a bizarre posture (christened arc-de-cercle) in which they arched their body backwards until they were supported only by their head and their heels.

The term "conversion disorder" originated with Freud. He viewed these apparently neurological symptoms as a result of the conversion of intrapsychic distress into physical symptoms. This distress was thought to cause the brain to unconsciously disable or impair a bodily function as a side effect of the original repression, which served to relieve the patient's anxiety.[44] However, some have claimed that patients do remain distressed by their symptoms in the long term[26]

It has also been suggested that at least some of the classic psychoanalytic cases of hysteria, such as "Anna O.",[45] may actually have suffered from organic illness. In fact, in Studies On Hysteria in which Breuer's Anna O. case was first presented, Freud wrote this: "Others of the patient's symptoms were not of a hysterical nature at all. This is true, for example, of the neck cramps, which I consider a modified version of migraine and which as such are not to be classified as a neurosis but as an organic disorder. Hysterical symptoms, however, regularly become attached to these." Freud believed that all hysterical symptoms ultimately have some organic components.[46]

See also[edit]

References[edit]

  1. ^ Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, American Psychiatric Association
  2. ^ a b Josef Breuer & Sigmund Freud, "Studies in Hysteria", 1895
  3. ^ a b Akagi, H. & House, A.O., 2001, The epidemiology of hysterical conversion. In P. Halligan, C. Bass, J. Marshall (Eds.) Hysterical Conversion: clinical and theoretical perspectives (pp. 73–87). Oxford: Oxford University Press.
  4. ^ a b The ICD-10 Classification of Mental and Behavioural Disorders: Clinical descriptions and diagnostic guidelines. World Health Organization. pp. 1–267. 
  5. ^ a b "Conversion disorder". Mayo Foundation for Medical Education and Research. Retrieved 25 October 2013. 
  6. ^ a b "Conversion disorder". National Center for Biotechnology Information, U.S. National Library of Medicine. Review Date: 11/17/2012. Retrieved 25 October 2013. 
  7. ^ a b Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, American Psychiatric Association
  8. ^ Freud S, "Dora: Fragment of an analysis of a case of hysteria.", 1905
  9. ^ Halligan, Peter W.; Bass, Christopher; Wade, Derick T. (2000). New approaches to conversion hysteria. 320:1488–1489, 3 June. British Medical Journal. 
  10. ^ Janet, P. "The Major Symptoms of Hysteria", 1920, 2nd Edition
  11. ^ Brown, RJ. "Psychological mechanisms of medically unexplained symptoms: an integrative conceptual model." Psychol Bull. 2004 Sep;130(5):793–812.
  12. ^ Roelofs K, Keijsers GP, Hoogduin KA, Näring GW, Moene FC., "Childhood abuse in patients with conversion disorder." Am J Psychiatry. 2002 Nov;159(11):1908–13.
  13. ^ Kanaan RA, Craig TK, Wessely SC, David AS. "Imaging repressed memories in motor conversion disorder." Psychosom Med. 2007 Feb–Mar;69(2):202–5.
  14. ^ Roelofs K, Hoogduin KA, Keijsers GP, Näring GW, Moene FC, Sandijck P. "Hypnotic susceptibility in patients with conversion disorder." J Abnorm Psychol. 2002 May;111(2):390–5.
  15. ^ Roelofs K, van Galen GP, Keijsers GP, Hoogduin CA. "Motor initiation and execution in patients with conversion paralysis." Acta Psychol (Amst). 2002 May;110(1):21–34.
  16. ^ Brown, R. J.; Cardena, E.; Nijenhuis, E.; Sar, V.; Van Der Hart, O. (2007). "Should Conversion Disorder Be Reclassified as a Dissociative Disorder in DSM V?". Psychosomatics 48 (5): 369–378. doi:10.1176/appi.psy.48.5.369. PMID 17878494.  edit
  17. ^ Bracha, H. (2006). "Human brain evolution and the "Neuroevolutionary Time-depth Principle:" Implications for the Reclassification of fear-circuitry-related traits in DSM-V and for studying resilience to warzone-related posttraumatic stress disorder". Progress in Neuro-Psychopharmacology and Biological Psychiatry 30 (5): 827–853. doi:10.1016/j.pnpbp.2006.01.008. PMID 16563589.  edit
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  19. ^ Eames P, 1992, "Hysteria following brain injury", Journal of Neurology, Neurosurgery, and Psychiatry, Vol 55, 1046–1053
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  21. ^ Stone J, Smyth R, Carson A, Warlow C, Sharpe M., "La belle indifference in conversion symptoms and hysteria: systematic review." Br J Psychiatry. 2006 Mar;188 pp. 204–9.
  22. ^ Stone J, Sharpe M, Carson A, Lewis SC, Thomas B, Goldbeck R, Warlow CP. "Are functional motor and sensory symptoms really more frequent on the left? A systematic review." J Neurol Neurosurg Psychiatry. 2002 Nov;73(5) pp. 578–81.
  23. ^ "Segal MM, Jurkat-Rott K, Levitt J, Lehmann-Horn F, Hypokalemic periodic paralysis - an owner's manual". Uni-ulm.de. 2009-06-05. Retrieved 2013-11-30. 
  24. ^ Slater, E. "Diagnosis of Hysteria"Br Med J 1965 May; 1 pp. 1395–99.
  25. ^ Slater ET, Glithero E. "A follow-up of patients diagnosed as suffering from "hysteria" J Psychosom Res 1965 Sep;9(1) pp. 9–13.
  26. ^ a b Stone, et al., JR Soc Med 2005; 98:547–548
  27. ^ Ron M, "The Prognosis of Hysteria" In P. Halligan, C. Bass, J. Marshall (Eds.) Hysterical Conversion: clinical and theoretical perspectives (pp. 73–87). Oxford: Oxford University Press.
  28. ^ Stone, et al., BMJ 2005
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  33. ^ http://www.doctorsofusc.com/condition/document/96743
  34. ^ Ruddy R, House A. Psychosocial interventions for conversion disorder. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD005331. doi:10.1002/14651858.CD005331.pub2
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  36. ^ Nimnuan C, Hotopf M, Wessely S. "Medically unexplained symptoms: an epidemiological study in seven specialities." J Psychosom Res. 2001 Jul;51(1):361–7.
  37. ^ Snijders TJ, de Leeuw FE, Klumpers UM, Kappelle LJ, van Gijn J. "Prevalence and predictors of unexplained neurological symptoms in an academic neurology outpatient clinic—an observational study." J Neurol. 2004 Jan;251(1):66–71.
  38. ^ Crimlisk HL, Bhatia KP, Cope H, David AS, Marsden D, Ron MA. "Patterns of referral in patients with medically unexplained motor symptoms." J Psychosom Res. 2000 Sep;49(3):217–9.
  39. ^ a b c Stefánsson JG, Messina JA, Meyerowitz S. "Hysterical neurosis, conversion type: clinical and epidemiological considerations." Acta Psychiatrica Scandinavica 1976 Feb;53(2):119–38.
  40. ^ a b c Deveci A, Taskin O, Dinc G, Yilmaz H, Demet MM, Erbay-Dundar P, Kaya E, Ozmen E. "Prevalence of pseudoneurologic conversion disorder in an urban community in Manisa, Turkey." Soc Psychiatry Psychiatr Epidemiol. 2007 Nov;42(11):857–64.
  41. ^ Tomasson K, Kent D, Coryell W. "Somatization and conversion disorders: comorbidity and demographics at presentation." Acta Psychiatrica Scandinavica 1991 Sep;84(3):288–93.
  42. ^ Kuloglu M, Atmaca M, Tezcan E, Gecici O, Bulut S. "Sociodemographic and clinical characteristics of patients with conversion disorder in Eastern Turkey." Soc Psychiatry Psychiatr Epidemiol. 2003 Feb;38(2):88–93.
  43. ^ Nicholson TRJ, Kanaan RAA. (2009). "Conversion Disorder". Psychiatry 8 (5): 164-169. Nicholson, T. R. J.; Kanaan, R. A. A. (2009). "Conversion disorder". Psychiatry 8 (5): 164. doi:10.1016/j.mppsy.2009.03.001.  edit
  44. ^ Breuer and Freud, "Studies in Hysteria", 1895
  45. ^ Alison Orr-Andrewes, "The case of Anna O: A Neuropsychiatric perspective", Journal of the Psychoanalytic Association 1987, vol 35 p.399.
  46. ^ ( Breuer and Freud, *Studies on Hysteria* Basic Books, Inc. 2000, pg.96).