Connective tissue

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Connective tissue (CT) is a kind of biological tissue that supports, connects, or separates different types of tissues and organs of the body. It is one of the four general classes of biological tissues—the others of which are epithelial, muscular, and nervous tissues.

All CT has three main components: cells, fibers, and extracellular matrices, all immersed in the body fluids.


Connective tissue can be broadly subdivided into connective tissue proper, special connective tissue, and series of other, less classifiable types of connective tissues.[1] Connective tissue proper consists of loose connective tissue and dense connective tissue (which is further subdivided into dense regular and dense irregular connective tissues.)[2] Special connective tissue consists of reticular connective tissue, adipose tissue, cartilage, bone, and blood.[3] Other kinds of connective tissues include fibrous, elastic, and lymphoid connective tissues.[4]

Fibroblasts are the cells responsible for the production of some CT.

Type-I collagen, is present in many forms of connective tissue, and makes up about 25% of the total protein content of the mammalian body.[5]


Characteristics of CT:

Types of fibers:

Collagenous fibers-Alpha polypeptide chainstendon, ligament, skin, cornea, cartilage, bone, blood vessels, gut, and intervertebral disc.
Elastic fibers-elastic microfibril & elastinextracellular matrix
Reticular fibers-Type-III collagenliver, bone marrow, lymphatic organs



It is estimated that 1 out of 10 people have a Connective Tissue Disorder.[8] Various CT in CT.

Staining of connective tissue[edit]

For microscopic viewing, the majority of the CT staining techniques color tissue fibers in contrasting shades. Collagen may be differentially stained by any of the following techniques:

See also[edit]


  1. ^ Shostak, Stanley. "Connective Tissues". Retrieved 9 December 2012. 
  2. ^ Potter, Hugh. "The Connective Tissues". Retrieved 9 December 2012. 
  3. ^ Caceci, Thomas. "Connective Tisues". Retrieved 9 December 2012. 
  4. ^ King, David. "Histology Intro". Retrieved 9 December 2012. 
  5. ^ Di Lullo, G. A. (2002). "Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen". Journal of Biological Chemistry 277 (6): 4223–31. doi:10.1074/jbc.M110709200. PMID 11704682. 
  6. ^ Xu, H. et al. (2008). "Monitoring Tissue Engineering Using Magnetic Resonance Imaging". Journal of Bioscience and Bioengineering 106 (6): 515–527. doi:10.1263/jbb.106.515. PMID 19134545. 
  7. ^ Laclaustra, M. et al. (2007). "Metabolic syndrome pathophysiology: The role of adiposetissue". Nutrition, Metabolism and Cardiovascular Diseases 17 (2): 125–139. doi:10.1016/j.numecd.2006.10.005. PMID 17270403. 
  8. ^ EDS (2012). "EDS Awareness Ehlers-Danlos Syndrome." Acquired by (

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