Connective tissue

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Connective tissue (CT) is a kind of animal tissue that supports, connects, or separates different types of tissues and organs of the body. It is one of the four general classes of animal tissues—as well as epithelial, muscle, and nervous tissues. Connective tissue is found everywhere including in the central nervous system. It is located in between other tissues.

All CT has three main components: fibers (with the exception of blood[1]), ground substance, and cells. All are immersed in the body fluids.


Connective tissue can be broadly subdivided into connective tissue proper, special connective tissue, and series of other, less classifiable types of connective tissues.[2] Connective tissue proper consists of loose connective tissue and dense connective tissue (which is further subdivided into dense regular and dense irregular connective tissues.)[3] Special connective tissue consists of reticular connective tissue, adipose tissue, cartilage, bone, and blood.[4] Other kinds of connective tissues include fibrous, elastic, and lymphoid connective tissues.[5]

Fibroblasts are the cells responsible for the production of some CT.

Type-I collagen, is present in many forms of connective tissue, and makes up about 25% of the total protein content of the mammalian body.[6]


Characteristics of CT:

Types of fibers:

Collagenous fibersBind bones and other tissues to each otherAlpha polypeptide chainstendon, ligament, skin, cornea, cartilage, bone, blood vessels, gut, and intervertebral disc.
Elastic fibersAllow organs like arteries and lungs to recoilelastic microfibril & elastinextracellular matrix
Reticular fibersForm a scaffolding for other cellsType-III collagenliver, bone marrow, and lymphatic organs


Clinical significance[edit]

It is estimated that 1 out of 10 people have a Connective Tissue Disorder.[9] Various CT in CT.

Staining of connective tissue[edit]

For microscopic viewing, the majority of the CT staining techniques color tissue fibers in contrasting shades. Collagen may be differentially stained by any of the following techniques:

See also[edit]

Notes and references[edit]

  1. ^ "Connective Tissue Study Guide". 2 January 2013. Retrieved 26 October 2014. 
  2. ^ Shostak, Stanley. "Connective Tissues". Retrieved 9 December 2012. 
  3. ^ Potter, Hugh. "The Connective Tissues". Retrieved 9 December 2012. 
  4. ^ Caceci, Thomas. "Connective Tisues". Retrieved 9 December 2012. 
  5. ^ King, David. "Histology Intro". Retrieved 9 December 2012. 
  6. ^ Di Lullo, G. A. (2002). "Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen". Journal of Biological Chemistry 277 (6): 4223–31. doi:10.1074/jbc.M110709200. PMID 11704682. 
  7. ^ Xu, H. et al. (2008). "Monitoring Tissue Engineering Using Magnetic Resonance Imaging". Journal of Bioscience and Bioengineering 106 (6): 515–527. doi:10.1263/jbb.106.515. PMID 19134545. 
  8. ^ Laclaustra, M. et al. (2007). "Metabolic syndrome pathophysiology: The role of adiposetissue". Nutrition, Metabolism and Cardiovascular Diseases 17 (2): 125–139. doi:10.1016/j.numecd.2006.10.005. PMID 17270403. 
  9. ^ EDS (2012). "EDS Awareness Ehlers-Danlos Syndrome." Acquired by (

External links[edit]