Co-codamol

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Co-codamol
Combination of
CodeineOpioid analgesic
ParacetamolAnilide analgesic
Clinical data
Pregnancy cat.C (US)
Legal statusPrescription Only (S4) (AU) POM/P (UK) Schedule III (US)
RoutesOral
Identifiers
ATC codeN02BE51
PubChemCID 11949633
ChemSpider10123946 YesY
 YesY (what is this?)  (verify)
 
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Co-codamol
Combination of
CodeineOpioid analgesic
ParacetamolAnilide analgesic
Clinical data
Pregnancy cat.C (US)
Legal statusPrescription Only (S4) (AU) POM/P (UK) Schedule III (US)
RoutesOral
Identifiers
ATC codeN02BE51
PubChemCID 11949633
ChemSpider10123946 YesY
 YesY (what is this?)  (verify)
Tylenol 3, a brand of co-codamol

Co-codamol (BAN) is a compound analgesic consisting of a combination of codeine phosphate and paracetamol (acetaminophen). Co-codamol tablets are used for the relief of mild to moderate pain when paracetamol or NSAIDS such as ibuprofen, aspirin or naproxen alone do not sufficiently relieve a patient's symptoms.

Co-codamol is marketed under various brand names in addition to the generic name.

Contents

Formulations

Seven strengths are available:

Formulations contain from 300 mg to 1000 mg (1 gram) of paracetamol per tablet.[1] In the United Kingdom the 15/500 and 30/500 tablets are available only with a prescription, although the 8/500 and 12.8/500 strengths are available over-the-counter. In Australia the 30/500 tablets are available only with a prescription, and the 10/500 and 15/500 tablets are Schedule 3 (Pharmacist Only Medicine). Manufacturer directions state not to exceed more than the recommended dosage of two tablets every four hours with a maximum of eight (8 x 500 mg) over a 24 hour period and no more than two (2 x 500 mg) at any one time. Other drugs containing paracetamol must be avoided unless otherwise directed by a physician or pharmacist, excessive amounts of paracetamol can lead to serious liver damage, see Paracetamol toxicity.

In the United States and Canada, Tylenol with codeine tablets contain either 8, 15, or 30 milligrams of codeine, named Tylenol No. 1, 2, or 3, respectively. There is also a Tylenol 4 containing 60 mg of codeine. All tablets contain 300 mg of paracetamol. No Tylenol with codeine products in the U.S. contain caffeine. In Canada, preparations of Tylenol #1, #2 and #3 each also contain 15 mg of caffeine to reduce drowsiness.[citation needed]

Co-codamol is marketed in the United States and Canada also under the generic name "Atasol Codeine". In the UK it is marketed as "Solpadeine Plus" and "Solpadeine Max", as well as "Solpadol". In Australia as "Panadeine", "Panadeine Extra" and "Panadeine Forte". Co-codamol is sold as "Paralgin Minor" (15/200), "Paralgin Forte" (30/400), "Paralgin Major" (60/800), "Pinex Forte" (30/500) and Pinex Major" (60/1000) in Norway.

Side effects

Side effects can include constipation, skin rashes, dizziness, sedation, shortness of breath, hypersensitivity reaction, fainting (syncope or near syncope), nausea and/or vomiting, confusion, loss of short-term memory, drowsiness, changes in blood, allergic reactions, euphoria, dysphoria, abdominal pain, pruritus (itching), easy bruising, bleeding gums, dry mouth and addiction.

Genetic differences between people give rise to differing rates of metabolism of codeine to morphine. In about 5% of people this may happen particularly fast, leading to higher levels of morphine being passed through breast milk in amounts potentially able to cause fatal respiratory depression of a breastfed baby.[2]

References

  1. ^ Tylenol with Codeine, from Drugs.com
  2. ^ CTV News, Codeine use while breastfeeding may be dangerous, Wed. Aug. 20 2008 9:42 PM ET

See also