Clobetasol propionate

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Clobetasol propionate
Systematic (IUPAC) name
[17-(2'-chloroacetyl)- 9-fluoro-11-hydroxy-10,13,16-trimethyl- 3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
Clinical data
AHFS/Drugs.commonograph
Pregnancy cat.C (US)
Legal status Prescription only
RoutesTopical
Identifiers
CAS number25122-46-7 YesY
ATC codeD07AD01
PubChemCID 32798
DrugBankDB01013
ChemSpider30399 YesY
UNII779619577M YesY
ChEBICHEBI:31414 YesY
ChEMBLCHEMBL1159650 YesY
Chemical data
FormulaC25H32ClFO5 
Mol. mass466.97 g/mol
 YesY (what is this?)  (verify)
 
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Clobetasol propionate
Systematic (IUPAC) name
[17-(2'-chloroacetyl)- 9-fluoro-11-hydroxy-10,13,16-trimethyl- 3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
Clinical data
AHFS/Drugs.commonograph
Pregnancy cat.C (US)
Legal status Prescription only
RoutesTopical
Identifiers
CAS number25122-46-7 YesY
ATC codeD07AD01
PubChemCID 32798
DrugBankDB01013
ChemSpider30399 YesY
UNII779619577M YesY
ChEBICHEBI:31414 YesY
ChEMBLCHEMBL1159650 YesY
Chemical data
FormulaC25H32ClFO5 
Mol. mass466.97 g/mol
 YesY (what is this?)  (verify)

Clobetasol propionate (phonetic pronunciation: kloh-BAY-tuh-sall[1]) is a corticosteroid used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several auto-immune diseases including alopecia areata, vitiligo and lichen planus (auto immune skin nodules).[2]

Clobetasol propionate is marketed and sold worldwide under numerous names including Clobex, Clob-x (Colombia), Cormax (Watson, US), Pentasol (Colombia), Cosvate (India), Temovate .In Pakistan it is marketed by Glaxosmithkine as " Dermovate".(US), Olux, Tenovate, Dermovate, Dermatovate, Butavate, Movate, Novate.[3]

Contents

Forms

Uses

Clobetasol propionate is used for the treatment of various skin disorders including eczema, psoriasis, and lichen sclerosus. It is also used to treat several auto-immune diseases including alopecia areata, vitiligo, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma).

Possible side effects

Pregnancy

According to the California Environmental Protection Agency, clobetasol propionate should not be used by pregnant women, or women expecting to become pregnant soon, as studies with rats shows a risk of birth defects:[5]

"Studies in the rat following oral administration at dosage levels up to 50 mg/kg per day revealed that the females exhibited an increase in the number of resorbed embryos and a decrease in the number of living fetuses at the highest dose. Pregnancy: Teratogenic Effects (i.e., possibility of causing abnormalities in fetuses): Pregnancy Category C: Clobetasol propionate has not been tested for teratogenicity when applied topically; however, it is absorbed percutaneously, and when administered subcutaneously it was a significant teratogen in both the rabbit and mouse. Clobetasol propionate has greater teratogenic potential than steroids that are less potent.There are no adequate and well-controlled studies of the teratogenic effects of clobetasol propionate in pregnant women. Temovate Cream and Ointment should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus."

References

External links