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Chronic Pain Syndrome (CPS) is a common problem that is a major challenge to health-care providers because of its complex nature of poor etiology and poor response to therapy. Most consider ongoing pain of 3~6 months are diagnostic. A person may have two or more co-existing pain conditions or wide spread generalized pain. This condition is managed best with a multidisciplinary approach.
Approximately 35% of Americans have some element of chronic pain,and approximately 50 million Americans are disabled partially or totally due to chronic pain. Major effects on the patient's life are depressed mood, fatigue, reduced activity, excessive use of drugs, dependent behavior, and disability. Parental chronic pain increases the risk of internalizing symptoms, including anxiety and depression in adolescents. 
Atypical chronic pain syndrome is characterized by patients who will present to dermatologists with complaints of burning, pain, or dysesthesias in the skin or mucous membranes for which no identifiable pathology can be found.:393
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