Chorioamnionitis

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Chorioamnionitis
Classification and external resources
Chorioamnionitis - high mag.jpg
Micrograph showing chorioamnionitis. The clusters of blue dots are inflammatory cells (neutrophils, eosinophils and lymphocytes). H&E stain.
ICD-10O41.1, P02.7
ICD-9658.4, 762.7
DiseasesDB31882
eMedicineped/89
MeSHD002821
 
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Chorioamnionitis
Classification and external resources
Chorioamnionitis - high mag.jpg
Micrograph showing chorioamnionitis. The clusters of blue dots are inflammatory cells (neutrophils, eosinophils and lymphocytes). H&E stain.
ICD-10O41.1, P02.7
ICD-9658.4, 762.7
DiseasesDB31882
eMedicineped/89
MeSHD002821

Chorioamnionitis is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection. It typically results from bacteria ascending into the uterus from the vagina and is most often associated with prolonged labor. The risk of developing chorioamnionitis increases with each vaginal examination that is performed in the final month of pregnancy, including during labor.[3]

Background[edit]

The fetal membranes consist of two parts:

Diagnosis[edit]

Intermediate magnification micrograph of moderate chorioamnionitis. H&E stain.

Clinical[edit]

Chorioamnionitis is diagnosed clinically in the setting of:[1]

Exclusions:

Pathologic[edit]

Chorioamnionitis can be diagnosed from a histologic examination of the fetal membranes.

Infiltration of the chorionic plate by neutrophils is diagnostic of (mild) chorioamnionitis. More severe chorioamnionitis involves subamniotic tissue and may have fetal membrane necrosis and/or abscess formation.

Severe chorioamnionitis may be accompanied by vasculitis of the umbilical blood vessels (due to the fetus' inflammatory cells) and, if very severe, funisitis (inflammation of the umbilical cord's connective tissue).

Treatment[edit]

Treatment consists of:

Associations[edit]

Chorioamnionitis is a risk factor for periventricular leukomalacia and cerebral palsy.[2]

See also[edit]

Notes[edit]

  1. ^ Elmar Peter Sakala, MD, MA, MPH, FACOG. Professor of GYNOB, Loma Linda University of medicine, California. Codirector of Student Clerkship. Dept of GYNOB
  2. ^ Wu YW, Colford JM (2000). "Chorioamnionitis as a risk factor for cerebral palsy: A meta-analysis". JAMA 284 (11): 1417–24. doi:10.1001/jama.284.11.1417. PMID 10989405. 

References[edit]

External links[edit]