Meclofenoxate

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Meclofenoxate
Centrophenoxine.svg
Systematic (IUPAC) name
2-Dimethylaminoethyl (4-chlorophenoxy)acetate
Clinical data
AHFS/Drugs.comInternational Drug Names
Legal status
?
Identifiers
CAS number51-68-3 YesY
ATC codeN06BX01
PubChemCID 4039
ChemSpider3899
UNIIC76QQ2I0RG YesY
KEGGD00993 YesY
Chemical data
FormulaC12H16ClNO3 
Mol. mass257.713
 YesY (what is this?)  (verify)
 
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Meclofenoxate
Centrophenoxine.svg
Systematic (IUPAC) name
2-Dimethylaminoethyl (4-chlorophenoxy)acetate
Clinical data
AHFS/Drugs.comInternational Drug Names
Legal status
?
Identifiers
CAS number51-68-3 YesY
ATC codeN06BX01
PubChemCID 4039
ChemSpider3899
UNIIC76QQ2I0RG YesY
KEGGD00993 YesY
Chemical data
FormulaC12H16ClNO3 
Mol. mass257.713
 YesY (what is this?)  (verify)

Meclofenoxate (Lucidril), also known as centrophenoxine, is a drug used to treat the symptoms of senile dementia and Alzheimer's disease. It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA). DMAE is a natural substance, found especially in fish. pCPA is a synthetic compound that resembles a variety of plant hormones called auxins.

In elderly patients, it has been clinically shown to improve memory, have a mentally stimulating effect, and improve general cognition.[1] Meclofenoxate also increases cellular membrane phospholipids.[citation needed]

It is also used off-label as a nootropic, often combined with a racetam drug such as piracetam.[citation needed]

Side effects and contraindications[edit]

Meclofenoxate is generally considered safe. However possible side effects may include nausea or mild dizziness. People with severely high blood pressure or convulsive disorders such as epilepsy should avoid meclofenoxate.[2][unreliable source?] Large doses may cause tight jaw clenching.

See also[edit]

References[edit]

  1. ^ Marcer, D; Hopkins, SM (1977). "The differential effects of meclofenoxate on memory loss in the elderly". Age and ageing 6 (2): 123–31. doi:10.1093/ageing/6.2.123. PMID 329662. 
  2. ^ Centrophenoxine Page @ The American Academy of Anti-Aging Medicine