Cefpodoxime

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Cefpodoxime
Systematic (IUPAC) name
(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
Trade namesGeneric (formerly Vantin)
AHFS/Drugs.commonograph
MedlinePlusa698024
Pregnancy cat.B1 (AU) B (US)
Legal status-only (US)
RoutesOral
Pharmacokinetic data
Bioavailability50%
Protein binding21% to 29%
MetabolismNegligible. Cefpodoxime proxetil is metabolized to cefpodoxime by the liver
Half-life2 hours
ExcretionRenal, unchanged
Identifiers
CAS number82619-04-3 YesY
ATC codeJ01DD13
PubChemCID 6335986
DrugBankDB01416
ChemSpider4891496 YesY
UNII7R4F94TVGY N
KEGGD07650 YesY
ChEBICHEBI:3504 N
ChEMBLCHEMBL1672 YesY
Chemical data
FormulaC15H17N5O6S2 
Mol. mass427.458 g/mol
 N (what is this?)  (verify)
 
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Cefpodoxime
Systematic (IUPAC) name
(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
Trade namesGeneric (formerly Vantin)
AHFS/Drugs.commonograph
MedlinePlusa698024
Pregnancy cat.B1 (AU) B (US)
Legal status-only (US)
RoutesOral
Pharmacokinetic data
Bioavailability50%
Protein binding21% to 29%
MetabolismNegligible. Cefpodoxime proxetil is metabolized to cefpodoxime by the liver
Half-life2 hours
ExcretionRenal, unchanged
Identifiers
CAS number82619-04-3 YesY
ATC codeJ01DD13
PubChemCID 6335986
DrugBankDB01416
ChemSpider4891496 YesY
UNII7R4F94TVGY N
KEGGD07650 YesY
ChEBICHEBI:3504 N
ChEMBLCHEMBL1672 YesY
Chemical data
FormulaC15H17N5O6S2 
Mol. mass427.458 g/mol
 N (what is this?)  (verify)

Cefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative organisms. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. Currently, it is only marketed as generic preparations in the USA, according the FDA Orange Book. It is commonly used to treat acute otitis media, pharyngitis, sinusitis, and gonorrhea. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment.

Pfizer, the parent company of Pharmacia & Upjohn, markets cefpodoxime proxetil under the trade name C-Doxim (C-doxim 50Dt,drysyp,100Dt/drysyp,200 and Cv200by Neomed(India) Simplicef for veterinary use. The dose range in dogs is 5–10 mg/kg body weight, administered orally, once a day.

(Finecure, India) markets the products under trade name Cefpo (Cefpo 100Dt, 200, Cv and Dry Syrup) [1]

Cefpodoxime inhibits cell wall synthesis by inhibiting final transpeptidation step of peptidoglycan synthesis in cell walls. It has well established pharmacokinetic profile with absorption of 50%. It is indicated in Community Acquired Pneumonia, Uncomplicated Skin and Skin Structure Infections and Uncomplicated Urinary Tract Infections.

Structural formula of cefpodoxime proxetil

Spectrum of bacterial susceptibility and resistance[edit]

Currently, bacterial like Citrobacter amalonaticus, Enterobacter intermedius and Listeria innocua are resistant toward Cefpodoxime. While Haemophilus influenzae, Neisseria gonorrhoeae, Salmonella Agona and Shigella boydii are susceptible to Cefpodoxime. Some of the bacterial like Bacteroides bivius, Clostridium difficile, Escherichia coli and Klebsiella pneumonia has developed resistance towards Cefpodoxime in varying degrees.[2]

References[edit]

  1. ^ "Anti Biotics and Anti Bacterial". Finecurepharmaceuticalsltd. Retrieved 2012-03-27. 
  2. ^ "Cefpodoxime Susceptibility and Resistance Data". Retrieved 23 July 2013. 

External links[edit]