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He was born in Smyrna (Turkey), the third son of William H. Cadoux and Emma Temple Cadoux. He was a student at Mansfield College, Oxford, where he was appointed (1914) Isherwood Fellow and Lecturer in Hebrew. He moved to the Yorkshire United Independent College at Shipley, in 1919, as professor of New Testament Criticism, Exegesis and Theology and of Christian Sociology.
In 1933 he returned to Oxford as Mackennal professor of Church History and vice-principal of Mansfield College. Linked to the Quakers, he participated to the Friends' Ambulance Unit and wrote many books on Christian Pacifism.
He was married to Marguerite Asplin.