Casomorphin

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Bovine β-casomorphin 7, a casomorphin, has seven amino acids in its peptide sequence.

Casomorphins are peptides, i.e., protein fragments, derived from the digestion of milk protein casein.[1]

There is no evidence that these peptides have any significance in human health.[1]

Health[edit]

Digestive enzymes can break casein down into peptides that have some biological activity in cells and in laboratory animals. They have not been shown to have any effect on humans[1] and they not been proven to be formed in the human digestive system.[2]

Although research has shown high rates of use of complementary and alternative therapies for children with autism, including gluten and/or casein exclusion diets, as of 2008 there was a lack of evidence that these diets had any effect.[3]

Some known casomorphins[edit]

β-Casomorphin 1-3[edit]

Bovine β-casomorphin 1-4[edit]

Bovine β-casomorphin 1-4, amide[edit]

Also known as morphiceptin

Bovine β-casomorphin 5[edit]

Bovine β-casomorphin 7[edit]

Bovine β-casomorphin 8[edit]

(Note: There is also a form of bovine β-Casomorphin 8 that has histidine instead of proline in position 8, depending on whether it is derived from A1 or A2 beta-casein.)

References[edit]

  1. ^ a b c European Food Safety Authority. 1 February 2009 Review of the potential health impact of β-casomorphins and related peptides
  2. ^ Clemens RA. Milk A1 and A2 peptides and diabetes. Nestle Nutr Workshop Ser Pediatr Program. 2011;67:187-95. doi: 10.1159/000325584. Epub 2011 Feb 16. PMID 21335999
  3. ^ Millward C, Ferriter M, Calver S, Connell-Jones G. Gluten- and casein-free diets for autistic spectrum disorder" Cochrane Database of Systematic Reviews 2008, Issue 2. Art. No.: CD003498. doi:10.1002/14651858.CD003498.pub3.