Plasma concentration of renin is measured prior to and following the administration of captopril. The CCT is considered positive if the renin levels increase substantially or the baseline renin level is abnormally high. An abnormal captopril test is indicative of the presence of renovascular disease.
^Gauthier B, Trachtman H, Frank R, Pillari G. Inadequacy of captopril challenge test for diagnosing renovascular hypertension in children and adolescents. Pediatr Nephrol. 1991 Jan;5(1):42-4. PMID 2025535.
^Muller FB, Sealey JE, Case DB, Atlas SA, Pickering TG, Pecker MS, Preibisz JJ, Laragh JH. The captopril test for identifying renovascular disease in hypertensive patients. Am J Med. 1986 Apr;80(4):633-44. PMID 3515933.
^Bales A. Hypertensive crisis. How to tell if it's an emergency or an urgency. Postgrad Med. 1999 May 1;105(5):119-26, 130. PMID 10335324. Free Full Text.