CD164

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CD164 molecule, sialomucin
Identifiers
SymbolsCD164 (; MGC-24; MUC-24; endolyn)
External IDsOMIM603356 MGI1859568 HomoloGene38129 GeneCards: CD164 Gene
Orthologs
SpeciesHumanMouse
Entrez876353599
EnsemblENSG00000135535ENSMUSG00000019818
UniProtQ04900Q9R0L9
RefSeq (mRNA)NM_001142401NM_016898
RefSeq (protein)NP_001135873NP_058594
Location (UCSC)Chr 6:
109.69 – 109.7 Mb
Chr 10:
41.52 – 41.53 Mb
PubMed search[1][2]
 
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CD164 molecule, sialomucin
Identifiers
SymbolsCD164 (; MGC-24; MUC-24; endolyn)
External IDsOMIM603356 MGI1859568 HomoloGene38129 GeneCards: CD164 Gene
Orthologs
SpeciesHumanMouse
Entrez876353599
EnsemblENSG00000135535ENSMUSG00000019818
UniProtQ04900Q9R0L9
RefSeq (mRNA)NM_001142401NM_016898
RefSeq (protein)NP_001135873NP_058594
Location (UCSC)Chr 6:
109.69 – 109.7 Mb
Chr 10:
41.52 – 41.53 Mb
PubMed search[1][2]

Sialomucin core protein 24 also known as endolyn or CD164 (cluster of differentiation 164) is a protein that in humans is encoded by the CD164 gene.[1][2] CD164 functions as a cell adhesion molecule.

Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play two key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor.[1]

References[edit]

  1. ^ a b Watt SM, Bühring HJ, Rappold I, Chan JY, Lee-Prudhoe J, Jones T, Zannettino AC, Simmons PJ, Doyonnas R, Sheer D, Butler LH (August 1998). "CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21". Blood 92 (3): 849–66. PMID 9680353. 
  2. ^ Zannettino AC, Bühring HJ, Niutta S, Watt SM, Benton MA, Simmons PJ (October 1998). "The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis". Blood 92 (8): 2613–28. PMID 9763543. 

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