c-jun

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Jun proto-oncogene

PDB rendering based on 1a02.
Available structures
PDBOrtholog search: PDBe, RCSB
Identifiers
SymbolsJUN; AP-1; AP1; c-Jun
External IDsOMIM165160 MGI96646 HomoloGene1679 ChEMBL: 4977 GeneCards: JUN Gene
RNA expression pattern
PBB GE JUN 201464 x at tn.png
PBB GE JUN 201465 s at tn.png
PBB GE JUN 201466 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez372516476
EnsemblENSG00000177606ENSMUSG00000052684
UniProtP05412P05627
RefSeq (mRNA)NM_002228.3NM_010591.2
RefSeq (protein)NP_002219.1NP_034721.1
Location (UCSC)Chr 1:
59.25 – 59.25 Mb
Chr 4:
95.05 – 95.05 Mb
PubMed search[1][2]
 
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Jun proto-oncogene

PDB rendering based on 1a02.
Available structures
PDBOrtholog search: PDBe, RCSB
Identifiers
SymbolsJUN; AP-1; AP1; c-Jun
External IDsOMIM165160 MGI96646 HomoloGene1679 ChEMBL: 4977 GeneCards: JUN Gene
RNA expression pattern
PBB GE JUN 201464 x at tn.png
PBB GE JUN 201465 s at tn.png
PBB GE JUN 201466 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez372516476
EnsemblENSG00000177606ENSMUSG00000052684
UniProtP05412P05627
RefSeq (mRNA)NM_002228.3NM_010591.2
RefSeq (protein)NP_002219.1NP_034721.1
Location (UCSC)Chr 1:
59.25 – 59.25 Mb
Chr 4:
95.05 – 95.05 Mb
PubMed search[1][2]

c-Jun is the name of a gene and protein that, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the JNK pathway but has also a phosphorylation-independent function. c-Jun knockout is lethal, but transgenic animals with a mutated c-Jun that cannot be phosphorylated (termed c-JunAA) can survive.

A recent study was carried out to evaluate the role of c-Jun in cellular proliferation and apoptosis of the endometrium throughout the menstrual cycle. Results suggest that the cyclic change of the c-jun protein levels is significant in the proliferation and apoptosis of glandular epithelial cells. The persistent stromal expression of c-jun protein may prevent stromal cells from entering into apoptosis during the late secretory phase.[1]

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein that is highly similar to the viral protein, and that interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.[2]

Contents

Interactions

c-jun has been shown to interact with Homeobox protein TGIF1,[3] ERG,[4] Retinoblastoma protein,[5] CREB binding protein,[6] Activating transcription factor 2,[7][8][9] Cofactor of BRCA1,[10] BRCA1,[11] C-Fos,[12][13][14][15][16][17][18] NFE2L1,[18] DDX21,[19] NFE2L2,[18] TATA binding protein,[20] RELA,[15] MAPK8,[21][22][23][24][25][26][27][28] Nuclear receptor co-repressor 2,[29] RFWD2,[30][31] PIN1,[32] FOSL1,[13] Mothers against decapentaplegic homolog 3,[33][34][35] ASCC3,[36] Transcription Factor II B,[20] CSNK2A2,[37] Casein kinase 2, alpha 1,[37] STAT1,[38] BCL6,[39] BCL3,[40] Androgen receptor,[41] STAT3,[38] ETS2,[42] ATF3,[9][43][44] NACA,[45] COP9 constitutive photomorphogenic homolog subunit 5,[46] DNA damage-inducible transcript 3,[47] RBM39,[48] Nuclear receptor coactivator 1,[49][50][51] MyoD,[52] RUNX2[53][54] and RUNX1.[53][54]

See also

References

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  2. ^ "Entrez Gene: JUN jun oncogene". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3725.
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  53. ^ a b Hess, J; Porte D, Munz C, Angel P (June 2001). "AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element". J. Biol. Chem. (United States) 276 (23): 20029–38. doi:10.1074/jbc.M010601200. ISSN 0021-9258. PMID 11274169.
  54. ^ a b D'Alonzo, Richard C; Selvamurugan Nagarajan, Karsenty Gerard, Partridge Nicola C (January 2002). "Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation". J. Biol. Chem. (United States) 277 (1): 816–22. doi:10.1074/jbc.M107082200. ISSN 0021-9258. PMID 11641401.

Further reading

  • Bohmann D, Bos TJ, Admon A, et al. (1988). "Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1". Science 238 (4832): 1386–92. doi:10.1126/science.2825349. PMID 2825349.
  • Rahmsdorf HJ (1997). "Jun: transcription factor and oncoprotein". J. Mol. Med. 74 (12): 725–47. doi:10.1007/s001090050077. PMID 8974016.
  • Liu JL, Kung HJ (2001). "Marek's disease herpesvirus transforming protein MEQ: a c-Jun analogue with an alternative life style". Virus Genes 21 (1–2): 51–64. doi:10.1023/A:1008132313289. PMID 11022789.
  • Velazquez Torres A, Gariglio Vidal P (2002). "[Possible role of transcription factor AP1 in the tissue-specific regulation of human papillomavirus]". Rev. Invest. Clin. 54 (3): 231–42. PMID 12183893.
  • Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (2007). "The activator protein-1 transcription factor in respiratory epithelium carcinogenesis". Mol. Cancer Res. 5 (2): 109–20. doi:10.1158/1541-7786.MCR-06-0311. PMID 17314269.

External links