Bromhexine

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Bromhexine
Systematic (IUPAC) name
2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy cat.A (Aus)
Legal status ?
Pharmacokinetic data
Bioavailability75-80%
Half-life12 hr
Identifiers
CAS number3572-43-8 YesY
ATC codeR05CB02
PubChemCID 2442
ChemSpider2348 YesY
UNIIQ1J152VB1P YesY
KEGGD07542 YesY
ChEMBLCHEMBL253376 YesY
Chemical data
FormulaC14H20Br2N2 
Mol. mass376.13
 YesY (what is this?)  (verify)
 
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Bromhexine
Systematic (IUPAC) name
2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy cat.A (Aus)
Legal status ?
Pharmacokinetic data
Bioavailability75-80%
Half-life12 hr
Identifiers
CAS number3572-43-8 YesY
ATC codeR05CB02
PubChemCID 2442
ChemSpider2348 YesY
UNIIQ1J152VB1P YesY
KEGGD07542 YesY
ChEMBLCHEMBL253376 YesY
Chemical data
FormulaC14H20Br2N2 
Mol. mass376.13
 YesY (what is this?)  (verify)

Bromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties.[1]

Function

Bromhexine supports the body's own natural mechanisms for clearing mucus from the respiratory tract.

It is secretolytic: that is, it increases the production of serous mucus in the respiratory tract and makes the phlegm thinner and less sticky. This contributes to a secretomotoric effect: it helps the cilia - tiny hairs that line the respiratory tract - to transport the phlegm out of the lungs. For this reason it is often added to some antitussive (cough) syrups.

Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. Bromhexine also enhances mucus transport by reducing mucus viscosity and by activating the ciliated epithelium. In clinical studies, Bromhexine showed secretolytic and secretomotoric effects in the bronchial tract area which facilitates expectoration and eases cough. It is indicated as "secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport". Bromhexine is contained in various formulations, high and low strength syrups 8 mg/5 ml, 4 mg/5 ml, tablets and soluble tablets (both with 8 mg bromhexine) and solution for oral use 10 mg/5 ml, adapted to the need of the patients. The physiosology varies with the age and weight, but there are products for all age groups from infant on. Bromhexine is a well established and well tolerated product in its indication.

Sometimes it is replaced by its metabolite ambroxol, as in Mucosolvan or Mucoangin.

Brand names

References

  1. ^ Morton, Ian; Hall, Judith (1999). Concise Dictionary of Pharmacological Agents. Springer. p. 55. ISBN 0-7514-0499-3. http://books.google.com/books?id=mqaOMOtk61IC&pg=PA55. Retrieved 2009-06-03.