As Nip/Tuck neared its sixth and final season, Falchuk and Murphy began to look for their next project and decided to focus on a lighter subject. They teamed up with Ian Brennan, who had written a screenplay about high school show choirs, to pitch a one-hour comedy about a glee club to the Fox Broadcasting Company. Their pitch was successful and turned into the television show Glee, which premiered in 2009. Falchuk, Murphy and Brennan received two Writers Guild of America Award nominations for Best Comedy Series and Best New Series. After the early success of Glee, Falchuk signed a two-year, seven-figure deal with 20th Century Fox Television which will involve further work on Glee as well as the development of other projects for the studio.
In 2011, Falchuk co-created the FX horror-drama anthology series American Horror Story with previous collaborator Ryan Murphy. The show premiered October 5, 2011, and received critical acclaim; the series was nominated for 17 Primetime Emmy Awards in 2012, and 15 Primetime Emmys in 2013, with Falchuk nominated for Outstanding Miniseries or Movie both years. In 2014, the show was once again nominated for 17 Primetime Emmys, with Falchuk nominated for Outstanding Writing for a Miniseries, Movie or a Dramatic Special.
Falchuk's brother, Evan Falchuk, founded the United Independent Party and is a candidate for Governor of Massachusetts in the Massachusetts gubernatorial election, 2014, and the president of Best Doctors, Inc. Falchuk is the son of Nancy Falchuk, the national president of the American Jewish women's organization Hadassah (as of 2007[update]). He has called Ryan Murphy his closest friend.
In 2008, Falchuk was diagnosed by his father and brother's medical consulting firm to have a serious problem with his spinal cord. After undergoing emergency spinal surgery, he recovered fully, but his experience inspired parts of the Glee episode "Wheels".