Louis Armstrong's 1949 recording charted in the Billboard Top 40, reaching #29. It was an international hit in 1956 for Fats Domino and has become a rock and roll standard. It reached #2 for three weeks on the Billboard Top 40 charts, becoming his biggest pop hit, and spent eight non-consecutive weeks at #1 on the R&B Best Sellers chart. The version by Fats Domino was also ranked #82 in Rolling Stone magazine's list of the 500 Greatest Songs of All Time. The song was Domino's greatest hit and remains the song most associated with him.
In the popular 1970s sitcomHappy Days, set in the 1950s, lead character Richie Cunningham, played by Ron Howard, would often sing "I found my thrill..." (the first line of Domino's 1950s version of "Blueberry Hill") in reference to pretty girls he dated or wanted to date.
It is one of the songs that the time traveling James Cole enjoys in the film, 12 Monkeys, and the song is later sung by the scientists upon his return to the future.
Joe Edwards' restaurant Blueberry Hill, on the Delmar Loop in St. Louis, Missouri, where Chuck Berry frequently plays, is named after the song.
The Far Side, a comic written by Gary Larson, features a comic parodying the lyrics of this song. A man is talking in a phone booth on top of a hill named "Blueberry Hill." He says into the phone "Norm? This is Mitch. ... You were right—I found my drill." The parody is of the line "found my thrill on Blueberry Hill."
Prime Minister of RussiaVladimir Putin made a cover performance of the song on December 10, 2010 before an audience of international film and television celebrities, in support of a charity for ill children. Videos of his performance quickly went viral worldwide.