Betamethasone

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Betamethasone
Betamethasone.png
Betamethasone2.png
Systematic (IUPAC) name
(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro- 3H-cyclopenta[a]phenanthren-3-one
Clinical data
Trade namesCelestone
AHFS/Drugs.commonograph
Pregnancy cat.C (US)
Legal status Prescription only
RoutesOral,Topical,IM
Pharmacokinetic data
Bioavailability ?
Metabolismhepatic CYP3A4
Half-life36-54 hours
ExcretionRenal (in urine)
Identifiers
CAS number378-44-9 YesY
ATC codeA07EA04 C05AA05 D07AC01 H02AB01 R01AD06 R03BA04 S01BA06 S02BA07 S03BA03
PubChemCID 9782
DrugBankDB00443
ChemSpider9399 YesY
UNII9842X06Q6M YesY
KEGGD00244 YesY
ChEBICHEBI:3077 YesY
ChEMBLCHEMBL632 YesY
Chemical data
FormulaC22H29FO5 
Mol. mass392.461
 YesY (what is this?)  (verify)
 
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Betamethasone
Betamethasone.png
Betamethasone2.png
Systematic (IUPAC) name
(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro- 3H-cyclopenta[a]phenanthren-3-one
Clinical data
Trade namesCelestone
AHFS/Drugs.commonograph
Pregnancy cat.C (US)
Legal status Prescription only
RoutesOral,Topical,IM
Pharmacokinetic data
Bioavailability ?
Metabolismhepatic CYP3A4
Half-life36-54 hours
ExcretionRenal (in urine)
Identifiers
CAS number378-44-9 YesY
ATC codeA07EA04 C05AA05 D07AC01 H02AB01 R01AD06 R03BA04 S01BA06 S02BA07 S03BA03
PubChemCID 9782
DrugBankDB00443
ChemSpider9399 YesY
UNII9842X06Q6M YesY
KEGGD00244 YesY
ChEBICHEBI:3077 YesY
ChEMBLCHEMBL632 YesY
Chemical data
FormulaC22H29FO5 
Mol. mass392.461
 YesY (what is this?)  (verify)

Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. It is applied as a topical cream, ointment, foam, lotion or gel to treat itching. Betamethasone sodium phosphate is sometimes prescribed as an intramuscular injection (I.M) for itching from various ailments, including allergic reactions to poison ivy and similar plants.

Forms[edit]

Betamethasone is available in a number of compound forms: betamethasone dipropionate (branded as Diprosone, Diprolene, Celestamine, Procort in Pakistan and others), sodium phosphate (branded as Bentelan in Italy[1]) and valerate (branded as Betnovate, Celestone, Fucibet, and others). In the United States and Canada, betamethasone is mixed with clotrimazole and sold as Lotrisone and Lotriderm. It is also available in combination with salicylic acid for using in psoriatic skin conditions.

Indications[edit]

Betamethasone is a corticosteroid used as a topical cream to relieve skin irritation, such as itching and flaking from eczema. It is used as a treatment for local psoriasis, as betamethasone dipropionate and salicylic acid, or as the combination betamethasone/calcipotriol. Betamethasone sodium phosphate is used orally and via injection with the same indications as other steroids.

In a randomized controlled trial Betamethasone was shown to reduce some of the ataxia symptoms associated with Ataxia Telangiectasia (A-T) by 28-31%.[2]

Alternative medical approach for large microcystic CCAMs – Betamethasone therapy[citation needed]

Bethamethasone is also used prior to delivery of a preterm baby to help prepare the lung for breathing.

Side effects[edit]

Prolonged use of this medicine on extensive areas of skin, broken or raw skin, skin folds or underneath airtight dressings may on rare occasions result in enough corticosteroid being absorbed to have side effects on other parts of the body; for example, by causing a decrease in the production of natural hormones by the adrenal glands.

A cream with 0.05% betamethasone appears effective in treating phimosis in boys, and often averts the need for circumcision.[3][4][5] It has replaced circumcision as the preferred treatment method for some physicians in the British National Health Service.[6][7]

Betamethasone is also used to stimulate fetal lung maturation (prevention of IRDS), and to decrease the incidence and mortality from intracranial hemorrhage in premature infants. However, because betamethasone crosses the placenta, which is required for its beneficial effects, it may also be associated with complications, such as hypoglycemia and leukocytosis in newborns exposed in utero.[citation needed]

See also[edit]

Betamethasone/dexchlorpheniramine

References[edit]

  1. ^ http://farmaco.agenziafarmaco.it/index.php?SEARCH=yes&DESCR_SPECIALITA2=BENTELAN
  2. ^ Zannolli, R; Buoni, S; Betti, G; Salvucci, S; Plebani, A; Soresina, A; Pietrogrande, MC; Martino, S; Leuzzi, V; Finocchi, A; Micheli, R; Rossi, LN; Brusco, A; Misiani, F; Fois, A; Hayek, J; Kelly, C; Chessa, L (Sep 1, 2012). "A randomized trial of oral betamethasone to reduce ataxia symptoms in ataxia telangiectasia.". Movement disorders : official journal of the Movement Disorder Society 27 (10): 1312–6. doi:10.1002/mds.25126. PMID 22927201. 
  3. ^ Van Howe RS (1998). "Cost-effective treatment of phimosis". Pediatrics 102 (4): E43. doi:10.1542/peds.102.4.e43. PMID 9755280.  A review of estimated costs and complications of 3 phimosis treatments.
  4. ^ Topical steroid application versus circumcision in pediatric patients with phimosis: a prospective randomized placebo controlled clinical trial, World Journal of Urology, 2008, 26, pp.187-190
  5. ^ Phimosis and topical steroids: new clinical findings, Pediatric Surgery International, 2007, 23, pp.331-335
  6. ^ Berdeu D, Sauze L, Ha-Vinh P, Blum-Boisgard C (2001). "Cost-effectiveness analysis of treatments for phimosis: a comparison of surgical and medicinal approaches and their economic effect". BJU Int. 87 (3): 239–44. doi:10.1046/j.1464-410x.2001.02033.x. PMID 11167650. 
  7. ^ Chu CC, Chen KC, Diau GY (1999). "Topical steroid treatment of phimosis in boys". J. Urol. 162 (3 Pt 1): 861–3. doi:10.1097/00005392-199909010-00078. PMID 10458396. 

External links[edit]