Benazepril

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Benazepril
Systematic (IUPAC) name
2-[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-
Clinical data
Trade namesLotensin
AHFS/Drugs.commonograph
MedlinePlusa692011
Pregnancy cat.D
Legal status Prescription only
RoutesOral
Pharmacokinetic data
Protein binding96.7%
MetabolismHepatic glucuronidation
Half-life10-11 hours
ExcretionRenal and biliary
Identifiers
CAS number86541-75-5 YesY
ATC codeC09AA07
PubChemCID 5362124
DrugBankDB00542
ChemSpider4514935 YesY
UNIIUDM7Q7QWP8 YesY
ChEBICHEBI:3011 YesY
ChEMBLCHEMBL838 YesY
Chemical data
FormulaC24H28N2O5 
Mol. mass424.49 g/mol
 YesY (what is this?)  (verify)
 
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Benazepril
Systematic (IUPAC) name
2-[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-
Clinical data
Trade namesLotensin
AHFS/Drugs.commonograph
MedlinePlusa692011
Pregnancy cat.D
Legal status Prescription only
RoutesOral
Pharmacokinetic data
Protein binding96.7%
MetabolismHepatic glucuronidation
Half-life10-11 hours
ExcretionRenal and biliary
Identifiers
CAS number86541-75-5 YesY
ATC codeC09AA07
PubChemCID 5362124
DrugBankDB00542
ChemSpider4514935 YesY
UNIIUDM7Q7QWP8 YesY
ChEBICHEBI:3011 YesY
ChEMBLCHEMBL838 YesY
Chemical data
FormulaC24H28N2O5 
Mol. mass424.49 g/mol
 YesY (what is this?)  (verify)

Benazepril, brand name Lotensin (Novartis), is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.

Contents

Dosage forms

Benazepril is available as oral tablets, in 5-, 10-, 20-, and 40-mg doses.

Benazepril is also available in combination with hydrochlorothiazide, under the trade name Lotensin HCT, and with amlodipine (trade name Lotrel).

Side effects

Most commonly, headaches and cough can occur with its use. Anaphylaxis, angioedema and hyperkalemia, the elevation of potassium levels, can also occur.

Benazepril may cause harm to the fetus during pregnancy.

Contraindications

Benazepril should be discontinued during pregnancy.

Kidney disease

According to a 2006 article in the New England Journal of Medicine, patients with advanced renal insufficiency taking benazepril showed "substantial" kidney benefits.[1]

A long-term study of patients' kidney disease revealed patients who took benazepril had better kidney function and slower progressions of kidney disease than their peers who took a placebo drug.[2] This is notable because this category of pharmaceuticals has long been thought to cause further kidney damage or increase the rate of progression for kidney disease.

According to coverage of the study on WebMD:

ACE inhibitors can pose a potential threat to kidneys as well. The key question was whether damaged kidneys would worsen if patients took ACE inhibitors. In a nutshell, concerns centered on blood levels of potassium and creatinine, waste products that are excreted by the kidneys. Testing creatinine levels in the blood is used as a way to monitor kidney function (...) kidney problems worsened more slowly in those taking Lotensin. Overall, there were no major differences in side effects between patients taking Lotensin or the placebo.[2]

This study marks the first indication that benazepril, and perhaps other ACE inhibitors, may actually be beneficial in the treatment of hypertension in patients with kidney disease.

Veterinary use

Under the brand names Fortekor (Novartis) and VetACE (Jurox Animal Health), benazepril hydrochloride is used to treat congestive heart failure in dogs and chronic renal failure in dogs and cats.

References

  1. ^ Hou F, Zhang X, Zhang G, Xie D, Chen P, Zhang W, Jiang J, Liang M, Wang G, Liu Z, Geng R (2006). "Efficacy and safety of benazepril for advanced chronic renal insufficiency". N Engl J Med 354 (2): 131–40. doi:10.1056/NEJMoa053107. PMID 16407508. 
  2. ^ a b Hitti, Miranda; Chang, Louise (January 11, 2006). "Drug May Treat Advanced Kidney Disease". WebMD. http://www.webmd.com/content/article/117/112524.htm. Retrieved 2006-09-07. 

External links