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|Classification and external resources|
|Classification and external resources|
Babesiosis is a malaria-like parasitic disease caused by infection with Babesia, a genus of protozoal piroplasms. Human babesiosis is common in the Northeastern and Midwestern United States, and sporadic throughout the rest of the world. Ticks transmit the human form of Babesiosis, so it often presents with other tick-borne illnesses such as Lyme disease. After trypanosomes, Babesia is thought to be the second most common blood parasite of mammals, and they can have a major impact on health of domestic animals in areas without severe winters. In cattle, a major host, the disease is known as Texas cattle fever, redwater or piroplasmosis.
Babesia species are in the phylum Apicomplexa, which also has the protozoan parasites that cause malaria, toxoplasmosis, and cryptosporidiosis. There are four clades of babesia species that infect humans. The main species in each clade are listed here:
Half of all children and a quarter of previously healthy adults are asymptomatic with Babesia infection. For those that develop symptoms, they are similar to malaria, because both cause fever and hemolytic anemia. People with symptoms usually become ill 1 to 4 weeks after the bite, or 1 to 9 weeks after transfusion of contaminated blood products. A person infected with babesiosis will gradually develop malaise and fatigue, followed by a fever. Hemolytic anemia, in which red blood cells are destroyed and removed, also develops. Chills, sweats, and thrombocytopenia (a low number of platelets in the blood) are also common symptoms.
Less common symptoms and physical exam findings of mild-to-moderate babesiosis:
In more severe cases, there are symptoms similar to malaria, with fevers up to 40.5 °C (105 °F), shaking chills, and severe anemia (hemolytic anemia). Organ failure may follow, including adult respiratory distress syndrome. Severe cases occur mostly in people who have had their spleen removed surgically. Severe cases are also more likely to occur in the very young, very old, and persons with immunodeficiency, such as HIV/AIDS patients.
A reported increase in human babesiosis diagnoses in the 2000s is thought to be caused by more widespread testing and higher numbers of people with immunodeficiencies coming in contact with ticks, the disease vector. Little is known about the occurrence of Babesia species in malaria-endemic areas, where Babesia can easily be misdiagnosed as Plasmodium.
Babesia parasites reproduce in red blood cells, where they can be seen as cross-shaped inclusions (four merozoites asexually budding, but attached together forming a structure looking like a "Maltese cross") and cause hemolytic anemia, quite similar to malaria.
Unlike the Plasmodium parasites that cause malaria, Babesia species lack an exoerythrocytic phase, so the liver is usually not affected.
In non-human animals, Babesia canis rossi, Babesia bigemina, and Babesia bovis cause particularly severe forms of the disease, including a severe haemolytic anaemia, with positive erythrocyte-in-saline-agglutination test indicating an immune-mediated component to the haemolysis. Common sequelae include haemoglobinuria "red-water", disseminated intravascular coaguation and "cerebral babesiosis" caused by sludging of erythrocytes in cerebral capillaries.
In bovine species, the organism causes hemolytic anemia, so an infected animal will show pale mucous membranes initially. As the levels of billirubin (a byproduct of red blood cell lysis) continue to increase, the visible mucous membranes will become yellow in color (icterus) due to the failure of the liver to metabolise the excess bilirubin. Hemoglobinuria will be seen due to excretion of red-blood-cell lysis byproducts via the kidneys. Fever of 40.5 °C (105 °F) develops due to release of inflammatory byproducts.
Only specialized laboratories can adequately diagnose Babesia infection in humans, and as a result Babesia infections are considered highly under-reported. It develops in patients who live in or travel to an endemic area or receive a contaminated blood transfusion within the preceding 9 weeks, so this aspect of the medical history is vital. Babesiosis may be suspected when a person with such an exposure history develops persistent fevers and hemolytic anemia. The definitive diagnostic test is the identification of parasites on a Giemsa-stained thin blood smear.
So-called "Maltese cross formations" on the blood film are essentially diagnostic of babesiosis, since they are not seen in malaria, the primary differential diagnosis. Careful examination of multiple smears may be necessary, since Babesia may infect less than 1% of circulating red blood cells and thus be easily overlooked.
Serologic testing for antibodies against Babesia (both IgG and IgM) can detect low-level infection in cases with a high clinical suspicion, but negative blood film examinations. Serology is also useful for differentiating babesiosis from malaria in cases where people are at risk for both infections. Since detectable antibody responses require about a week after infection to develop, serologic testing may be falsely negative early in the disease course.
A polymerase chain reaction (PCR) test has been developed for the detection of Babesia from the peripheral blood. PCR may be at least as sensitive and specific as blood film examination in diagnosing babesiosis, though it is also significantly more expensive. Most often, PCR testing is used in conjunction with blood film examination and possibly serologic testing.
In animals, babesiosis is suspected by observation of clinical signs (haemoglobinuria and anaemia) in animals in endemic areas. Diagnosis is confirmed by observation of merozoites on thin film blood smear examined at maximum magnification under oil using Romonovski stains (methylene blue and eosin). This is a routine part of the veterinary examination of dogs and ruminants in regions where babesiosis is endemic.
Babesia canis and B. bigemina are "large Babesias" that form paired merozoites in the erythrocytes, commonly described as resembling "two pears hanging together", rather than the "Maltese Cross" of the "small babesias". Their merozoites are approximately twice the size of small Babesias.
Cerebral babesiosis is suspected in vivo when neurological signs (often severe) are seen in cattle that are positive for B. bovis on blood smear, but this has yet to be proven scientifically. Outspoken red discolouration of the grey matter post mortem further strengthens suspicion of cerebral babesiosis. Diagnosis is confirmed post mortem by observation of Babesia-infected erythrocytes sludged in the cerebral cortical capillaries in a brain smear.
In mild-to-moderate babesiosis, the treatment of choice is a combination of atovaquone and azithromycin. This regimen is preferred to clindamycin and quinine because there are fewer side-effects. The standard course is 7 to 10 days, but this is extended to at least 6 weeks in people with relapsing disease. It is recommended that even mild cases are treated to decrease the chance of inadvertently transmitting the infection by donating blood. In life-threatening cases, exchange transfusion is performed. In this procedure, the infected red blood cells are removed and replaced with uninfected ones. Imizol is a drug used for treatment of Babesiosis in dogs. Extracts of the poisonous, bulbous plant Boophone disticha are used in the folk medicine of South Africa to treat equine babesiosis. B.disticha is a member of the daffodil family Amaryllidaceae and has also been used in preparations employed as arrow poisons, hallucinogens and in embalming. The plant is rich in alkaloids, some of which display an action similar to that of scopolamine.
Babesiosis is a vector-borne illness usually transmitted by Ixodes scapularis ticks. Babesia microti uses the same tick vector as Lyme disease and ehrlichiosis, and may occur in conjunction with these other diseases. The organism can also be transmitted by blood transfusion. Ticks of domestic animals, especially Rhipicephalus (Boophilus) microplus and R. (B.) decoloratus transmit several species of Babesia to livestock animals, causing considerable economic losses to farmers in tropical and subtropical regions.
In the United States, the majority of Babesiosis cases are caused by B. microti, and occur in the Northeast and northern Midwest from May through October. Areas with especially high rates include eastern Long Island, Fire Island, Nantucket Island and Martha's Vineyard off of the coast of Massachusetts.
In Europe, B. divergens is the primary cause of infectious babesiosis and is transmitted by I. ricinus.
Babesiosis has emerged in Lower Hudson Valley, New York since 2001.
In Australia, babesiosis of types B. duncani and B. microti, has recently been found in symptomatic patients along the eastern coastline of the continent. A similar disease in cattle, commonly known as tick fever, is spread by Babesia bovis and B. bigemina in the introduced cattle tick Rhipicephalus microplus. This disease is found in eastern and northern Australia.
A table of isolated cases of babesiosis, which may be underestimated given how widely distributed the tick vectors are in temperate latitudes.
|Pacific Coast (northern California to Washington)||B. duncani|
|Kentucky, Missouri, and Washington State||B. divergens|
|Austria, Germany, Italy||B. venatorum|
|Canary islands||B. microti|
|Africa (Egypt, Mozambique, South Africa)||Uncharacterized babesia spp.|
|Asia (Taiwan, Japan)||B. microti|
|South Korea||Babesia KO1|
|Australia||B. microti, B. duncani|
|South America (Brazil, Colombia)||Uncharacterized babesia spp.|
The disease is named for the genus of the causative organism, which was named after the Romanian bacteriologist Victor Babeş. In 1888, Victor Babes identified the microorganisms in red blood cells as the cause of febrile hemoglobinuria in cattle. In 1893, Theobald Smith and Frederick Kilborne discovered that a tick was the vector for transmission in Texas cattle. The agent was B. bigemina. This was the first demonstration that an arthropod could act as a disease vector to transmit an infectious agent to a vertebrate host.
In 1957, the first human case was documented in a splenectomized Croatian herdsman. The agent was B. divergens. In 1969, the first case was reported in an immunocompetent individual on Nantucket Island. The agent was B. microti, and the vector was the tick I. scapularis.
Veterinary treatment of babesiosis does not normally use antibiotics. In non-human animals, diminazen (Berenil), imidocarb or trypan blue would be the drugs of choice for treatment of B. canis rossi (dogs in Africa), B. bovis, and B. bigemina (cattle in Southern Africa). In acute cases in cattle blood transfusion may be carried out.
A vaccine is effective against B. canis canis (dogs in the Mediterranean region), but is ineffective against B. c. rossi. Babesia imitans causes a mild form of the disease that frequently resolves without treatment (dogs in southeast Asia).
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