Bruton's tyrosine kinase

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Bruton agammaglobulinemia tyrosine kinase

PH domain of Bruton's tyrosine kinase dimer with bound lipids. Blue plane shows hydrocarbon boundary of the lipid bilayer
Available structures
PDBOrtholog search: PDBe, RCSB
Identifiers
SymbolsBTK (; AGMX1; AT; ATK; BPK; IMD1; PSCTK1; XLA)
External IDsOMIM300300 MGI88216 HomoloGene30953 ChEMBL: 5251 GeneCards: BTK Gene
EC number2.7.10.2
RNA expression pattern
PBB GE BTK 205504 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez69512229
EnsemblENSG00000010671ENSMUSG00000031264
UniProtQ06187P35991
RefSeq (mRNA)NM_000061NM_013482
RefSeq (protein)NP_000052NP_038510
Location (UCSC)Chr HG1439_PATCH:
100.6 – 100.64 Mb
Chr X:
134.54 – 134.58 Mb
PubMed search[1][2]
 
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Bruton agammaglobulinemia tyrosine kinase

PH domain of Bruton's tyrosine kinase dimer with bound lipids. Blue plane shows hydrocarbon boundary of the lipid bilayer
Available structures
PDBOrtholog search: PDBe, RCSB
Identifiers
SymbolsBTK (; AGMX1; AT; ATK; BPK; IMD1; PSCTK1; XLA)
External IDsOMIM300300 MGI88216 HomoloGene30953 ChEMBL: 5251 GeneCards: BTK Gene
EC number2.7.10.2
RNA expression pattern
PBB GE BTK 205504 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez69512229
EnsemblENSG00000010671ENSMUSG00000031264
UniProtQ06187P35991
RefSeq (mRNA)NM_000061NM_013482
RefSeq (protein)NP_000052NP_038510
Location (UCSC)Chr HG1439_PATCH:
100.6 – 100.64 Mb
Chr X:
134.54 – 134.58 Mb
PubMed search[1][2]

Bruton's tyrosine kinase (abbreviated Btk or BTK) is a type of kinase enzyme implicated in the primary immunodeficiency disease X-linked agammaglobulinemia (Bruton's agammaglobulinemia). Its exact mechanism of action remains unknown, but it plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor. Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The Btk gene is located on the X chromosome.[1] At least 400 mutations of the Btk gene have been identified.

Btk contains a PH domain that binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3). PIP3 binding induces Btk to phosphorylate phospholipase C, which in turn hydrolyzes PIP2, a phosphatidylinositol, into two second messengers, inositol triphosphate (IP3) and diacylglycerol (DAG), which then go on to modulate the activity of downstream proteins during B-cell signalling.

Bruton's tyrosine kinase was discovered in 1993 and is named for Ogden Bruton, who first described XLA in 1952.[1]

Interactions[edit]

Bruton's tyrosine kinase has been shown to interact with GNAQ,[2] PLCG2,[3][4] Protein kinase D1,[5] B-cell linker,[3][6] SH3BP5,[7][8] Caveolin 1,[9] ARID3A[10] and GTF2I.[11][12][13]

See also[edit]

References[edit]

  1. ^ a b X-Linked Agammaglobulinemia Patient and Family Handbook for The Primary Immune Diseases. Third Edition. 2001. Published by the Immune Deficiency Foundation.
  2. ^ Ma, Y C; Huang X Y (October 1998). "Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (21): 12197–201. doi:10.1073/pnas.95.21.12197. ISSN 0027-8424. PMC 22808. PMID 9770463. 
  3. ^ a b Yasuda, Tomoharu; Tezuka Tohru, Maeda Akito, Inazu Tetsuya, Yamanashi Yuji, Gu Hua, Kurosaki Tomohiro, Yamamoto Tadashi (July 2002). "Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells". J. Exp. Med. (United States) 196 (1): 51–63. doi:10.1084/jem.20020068. ISSN 0022-1007. PMC 2194016. PMID 12093870. 
  4. ^ Guo, B; Kato R M, Garcia-Lloret M, Wahl M I, Rawlings D J (August 2000). "Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex". Immunity (UNITED STATES) 13 (2): 243–53. doi:10.1016/S1074-7613(00)00024-8. ISSN 1074-7613. PMID 10981967. 
  5. ^ Johannes, F J; Hausser A, Storz P, Truckenmüller L, Link G, Kawakami T, Pfizenmaier K (November 1999). "Bruton's tyrosine kinase (Btk) associates with protein kinase C mu". FEBS Lett. (NETHERLANDS) 461 (1-2): 68–72. doi:10.1016/S0014-5793(99)01424-6. ISSN 0014-5793. PMID 10561498. 
  6. ^ Hashimoto, S; Iwamatsu A, Ishiai M, Okawa K, Yamadori T, Matsushita M, Baba Y, Kishimoto T, Kurosaki T, Tsukada S (October 1999). "Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling". Blood (UNITED STATES) 94 (7): 2357–64. ISSN 0006-4971. PMID 10498607. 
  7. ^ Matsushita, M; Yamadori T, Kato S, Takemoto Y, Inazawa J, Baba Y, Hashimoto S, Sekine S, Arai S, Kunikata T, Kurimoto M, Kishimoto T, Tsukada S (April 1998). "Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK)". Biochem. Biophys. Res. Commun. (UNITED STATES) 245 (2): 337–43. doi:10.1006/bbrc.1998.8420. ISSN 0006-291X. PMID 9571151. 
  8. ^ Yamadori, T; Baba Y, Matsushita M, Hashimoto S, Kurosaki M, Kurosaki T, Kishimoto T, Tsukada S (May 1999). "Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (11): 6341–6. doi:10.1073/pnas.96.11.6341. ISSN 0027-8424. PMC 26883. PMID 10339589. 
  9. ^ Vargas, Leonardo; Nore Beston F, Berglof Anna, Heinonen Juhana E, Mattsson Pekka T, Smith C I Edvard, Mohamed Abdalla J (March 2002). "Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx". J. Biol. Chem. (United States) 277 (11): 9351–7. doi:10.1074/jbc.M108537200. ISSN 0021-9258. PMID 11751885. 
  10. ^ Nixon, Jamee C; Rajaiya Jaya B, Ayers Neil, Evetts Seth, Webb Carol F (March 2004). "The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations". Cell. Immunol. (United States) 228 (1): 42–53. doi:10.1016/j.cellimm.2004.03.004. ISSN 0008-8749. PMID 15203319. 
  11. ^ Sacristán, Catarina; Tussié-Luna María Isabel, Logan Sheila M, Roy Ananda L (February 2004). "Mechanism of Bruton's tyrosine kinase-mediated recruitment and regulation of TFII-I". J. Biol. Chem. (United States) 279 (8): 7147–58. doi:10.1074/jbc.M303724200. ISSN 0021-9258. PMID 14623887. 
  12. ^ Novina, C D; Kumar S, Bajpai U, Cheriyath V, Zhang K, Pillai S, Wortis H H, Roy A L (July 1999). "Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase". Mol. Cell. Biol. (UNITED STATES) 19 (7): 5014–24. ISSN 0270-7306. PMC 84330. PMID 10373551. 
  13. ^ Yang, W; Desiderio S (January 1997). "BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (2): 604–9. doi:10.1073/pnas.94.2.604. ISSN 0027-8424. PMC 19560. PMID 9012831. 

External links[edit]

Further reading[edit]

  • Ochs HD, Aruffo A (1994). "Advances in X-linked immunodeficiency diseases.". Curr. Opin. Pediatr. 5 (6): 684–91. doi:10.1097/00008480-199312000-00008. PMID 7907259. 
  • Uckun FM (1998). "Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis.". Biochem. Pharmacol. 56 (6): 683–91. doi:10.1016/S0006-2952(98)00122-1. PMID 9751072. 
  • Tsubata T, Wienands J (2002). "B cell signaling. Introduction.". Int. Rev. Immunol. 20 (6): 675–8. PMID 11913944. 
  • Etzioni A (2002). "Novel aspects of hypogammaglobulinemic states.". Isr. Med. Assoc. J. 4 (4): 294–7. PMID 12001708. 
  • Niiro H, Clark EA (2003). "Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1.". Immunity 19 (5): 637–40. doi:10.1016/S1074-7613(03)00303-0. PMID 14614850. 
  • Carpenter CL (2004). "Btk-dependent regulation of phosphoinositide synthesis.". Biochem. Soc. Trans. 32 (Pt 2): 326–9. doi:10.1042/BST0320326. PMID 15046600. 
  • Hendriks RW, Kersseboom R (2006). "Involvement of SLP-65 and Btk in tumor suppression and malignant transformation of pre-B cells.". Semin. Immunol. 18 (1): 67–76. doi:10.1016/j.smim.2005.10.002. PMID 16300960.