Azerizin

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Azerizin is claimed to be a proprietary blend of the natural ingredients nicotinamide, azelaic acid, quercetin and curcumin that purportedly combine the anti-inflammatory and antimicrobial properties, along with inhibiting effects on sebum production.[1]

The cascade of events in the inflammatory pathway that result from cell membrane disruption is well documented.[2][3] The release of membrane phospholipids leads to increased production of arachidonic acid which in turn results in elevated leukotriene, prostaglandin and thromboxane production (Fig. 1). The ingredients in Azerizin™ are known to inhibit each of these three major paths of inflammation by blocking or down-regulating pro-inflammatory catalysts at multiple points in the inflammatory cascade, e.g., inhibition of phospholipase, lipooxygenase, COX-2, leukotrienes, thromboxane, prostaglandins, nitric oxide, monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor (TNF) and interleukin-12.[4][5][6][7]

In addition to these anti-inflammatory actions, the components of Azerizin possess potent antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermis, at least in part attributed to inhibition of microbial cellular protein synthesis.[8][9][10] Azerizin was developed by scientists at Elorac, Inc. for use as an adjunct in the management of acne vulgaris and rosacea.

References[edit]

  1. ^ "Elorac, Inc.". 
  2. ^ Herskowitz, Ahvie; Mangano, Dennis T. (November 1996). "Inflammatory Cascade: A Final Common Pathway for Perioperative Injury?". Anesthesiology: 85 (5): 957–960. doi:10.1097/00000542-199611000-00001. 
  3. ^ Chainani-wu, Nita (2003). "Safety and Anti-Inflammatory Activity of Curcumin: A Component of Tumeric {sic} (Curcuma longa)". The Journal of Alternate and Complementary Medicine 9: 161–168. doi:10.1089/107555303321223035. 
  4. ^ Chirumbolo, S (Sep 2010). "The role of quercetin, flavonols and flavones in modulating inflammatory cell function". Inflamm Allergy Drug Targets 9 (4): 263–85. doi:10.2174/187152810793358741. 
  5. ^ Fivenson, DP (Jan 2006). "The mechanisms of action of nicotinamide and zinc in inflammatory skin disease". Cutis ((1 Suppl)): 5–10. 
  6. ^ Jurenka, Julie S (2 Nov 2009). "Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research". Alternative Medicine Review 14 (f2): 141–153. 
  7. ^ Shalita, A; Falcon R; Olansky A; Oannotta P; Akhavan A; Day D; Janiga A; Singri P et al. (2012). "Inflammatory acne management with a novel prescription dietary supplement". J of Drugs in Derm 11. 
  8. ^ Liu, C; Huang H (2013). "In Vitro Anti-Propionibacterium Activity by Curcumin Containing Vesicle System". Chem Pharm Bull 61 (4): 419–425. doi:10.1248/cpb.c12-01043. 
  9. ^ "azelaic acid - Compound Summary". PubChem. 
  10. ^ Fitton, Andrew; Goa, Karen L (1991). "Azelaic acid: A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders". Drugs 41 (5): 780–798. doi:10.2165/00003495-199141050-00007. 

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