Auto-brewery syndrome, also known as gut fermentation syndrome, is a rare medical condition in which intoxicating quantities of alcohol are produced through endogenous fermentation within the digestive system. [1 ] Numerous cases have been documented in the medical literature. [2 ] One gastrointestinal organism, [3 ] has been identified as a pathogen for this condition. Saccharomyces cerevisiae,
Claims of endogenous fermentation of this type have been used as a defense against drunk driving charges.
[4 ] [5 ]
One case went undetected for 20 years.
It has also been investigated, but eliminated, as a possible cause of
sudden infant death syndrome. [7 ]
The antifungal drug
fluconazole can be effective treatment for the condition since the drug is capable of killing Saccharomyces cerevisiae in the gastrointestinal tract. [2 ] References [edit ] ^ Michaeleen Doucleff (September 17, 2013). "Auto-Brewery Syndrome: Apparently, You Can Make Beer In Your Gut". NPR. ^ a b Cordell, Barbara; McCarthy, Justin (2013). "A Case Study of Gut Fermentation Syndrome (Auto-Brewery) with . Saccharomyces cerevisiae as the Causative Organism" International Journal of Clinical Medicine. pp. 309–312. doi: 10.4236/ijcm.2013.47054. ^ Kaji, H.; Asanuma, Y.; Yahara, O.; Shibue, H.; Hisamura, M.; Saito, N.; Kawakami, Y.; Murao, M. (1984). "Intragastrointestinal Alcohol Fermentation Syndrome: Report of Two Cases and Review of the Literature". Journal of the Forensic Science Society 24 (5): 461–471. doi: 10.1016/S0015-7368(84)72325-5. PMID 6520589. ^ Logan BK, Jones AW (July 2000). "Endogenous ethanol 'auto-brewery syndrome' as a drunk-driving defence challenge". Medicine, Science, and the law . Retrieved 2013-02-27. ^ Cecil Adams (October 20, 2006). "Designated drunk: Can you get intoxicated without actually drinking alcohol?". The Straight Dope . Retrieved 2013-02-27. ^ Gazette, Evening (Oct 7, 2013). "Auto-brewery syndrome: Teetotal Teesville man can't stay sober as everything he eats turns to alcohol" . Retrieved 22 April 2014. ^ P. Geertinger MD, J. Bodenhoff, K. Helweg-Larsen, A. Lund (1982-09-01). "Endogenous alcohol production by intestinal fermentation in sudden infant death". Zeitschrift für Rechtsmedizin. Springer-Verlag . Retrieved 2013-02-27.